Rational Design Strategies for Advanced Hydrogel-based Sensing Platforms

doi:10.19586/j.2095-2341.2026.0017

Current Biotechnology ›› 2026, Vol. 16 ›› Issue (2): 215-224.DOI: 10.19586/j.2095-2341.2026.0017

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Rational Design Strategies for Advanced Hydrogel-based Sensing Platforms

Yuan SU¹^,²(), Weiwei JIAO³, Longjiao ZHU¹^,², Wentao XU¹^,²()

^1.Department of Nutrition and Health，China Agricultural University，Beijing 100193，China
^2.Key Laboratory of Food Precision Nutrition and Quality Control，Ministry of Education，Beijing 100193，China
^3.Beijing Key Laboratory of Core Technologies for the Prevention and Treatment of Emerging Infectious Diseases in Children，Key Laboratory of Major Diseases in Children，Ministry of Education，National Clinical Research Center for Respiratory Diseases，Laboratory of Respiratory Diseases，Beijing Pediatric Research Institute，Beijing Children's Hospital，Capital Medical University，National Center for Children's Health，Beijing 100045，China

Received:2026-01-10 Accepted:2026-01-26 Online:2026-03-25 Published:2026-04-27
Contact: Wentao XU

Abstract

Abstract:

Sensing technology serves as a cornerstone for health and environmental monitoring， yet its advancement is constrained by the inadequate biocompatibility and mechanical compatibility of traditional interface materials. Hydrogels， as a class of hydrophilic three-dimensional network soft materials， offer an ideal platform to address this bottleneck owing to their biomimetic features and tunable physicochemical properties. For the first time， this review systematically summarized and elaborated on eight rational design paradigms for hydrogel-based sensors， including functional nucleic acid programming， enzymatic catalysis and biomolecular recognition， synthetic supramolecular modules， nanocomposite integration， physical confinement effects， stimulus-responsive polymer systems， microneedle-based sensing， and flexible wearable device integration. These paradigms clarified the central role of hydrogels as either active responsive units or passive optimization matrices across different strategies. The work aims to provide a systematic rational design framework for relevant research， facilitating a paradigm shift in the field from empirical exploration toward rational construction.

Key words: hydrogel, sensor, detection, rational design

CLC Number:

Q819

Yuan SU, Weiwei JIAO, Longjiao ZHU, Wentao XU. Rational Design Strategies for Advanced Hydrogel-based Sensing Platforms[J]. Current Biotechnology, 2026, 16(2): 215-224.

Figures/Tables 2

References 77

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Rational Design Strategies for Advanced Hydrogel-based Sensing Platforms

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