Curr. Biotech. ›› 2013, Vol. 3 ›› Issue (3): 171-178.DOI: 10.3969/j.issn.2095-2341.2013.0 .

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Comparative Genomics Analysis of DNA Repair Systems in Deinococcus radiodurans

WANG Lin, ZHOU Zheng-fu, ZHANG Wei, CHEN Ming, CHEN Wu-ling, LIN Min   

  1. 1.Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China;
    2.Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education; Northwest University, Xian 710069, China
  • Received:2013-03-11 Online:2013-05-25 Published:2013-04-20

比较基因组学分析耐辐射异常球菌DNA损伤修复系统

王琳1,2,周正富1,张维1,陈明1,陈五岭2,林敏1*   

  1. 1.中国农业科学院生物技术研究所， 北京 100081;
    2.西北大学，西部资源生物与现代生物技术省部共建教育部重点实验室， 西安 710069
  • 通讯作者: 林敏，研究员，博士，博士生导师，主要从事固氮微生物及特殊环境微生物的分子生物学和基因工程研究。E-mail：linmin57@vip.163.com
  • 作者简介:王琳，硕博连读生，研究方向抗逆微生物分子生物学。
  • 基金资助:

    国家自然科学基金项目（31170105）；农业部公益性行业科研专项（201103007）；国家转基因生物新品种培育重大专项（2013ZX08012-001,2013ZX08009-003）；国家863计划项目（2012AA063503）资助。

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Abstract: Deinococcus radiodurans is extremely resistant to various DNA-damaging. The diversity of DNA damage withstood by D. radiodurans is commensurate with the selection of DNA repair pathways at its disposal: direct damage reversal, base and nucleotide excision repair, mismatch repair, and recombinational repair. In this article, we have tried to bring information together to give a broad perspective of DNA repair systems in D. radiodurans.

Key words: Deinococcus radiodurans, excision repair, mismatch repair, recombinational repair

摘要： 耐辐射异常球菌对各种DNA损伤均有极好的抗性，该菌选择不同的DNA修复途径来应对清除不同DNA损伤，包括直接DNA反转、碱基和核苷酸切除修复、错配修复和重组修复等。本文对耐辐射异常球菌中重要的同源重组修复系统进行了综述。

关键词: 耐辐射异常球菌, 切除修复, 错配修复, 重组修复

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