Research Progress on the Active Ingredients and Pharmacological Effects of Fermented Soybean Paste

doi:10.19586/j.2095-2341.2025.0176

Current Biotechnology ›› 2026, Vol. 16 ›› Issue (2): 277-287.DOI: 10.19586/j.2095-2341.2025.0176

• Reviews • Previous Articles

Research Progress on the Active Ingredients and Pharmacological Effects of Fermented Soybean Paste

Honglin CHEN(), Jinjin SHEN, Mengge LI, Yan WANG()

College of Traditional Chinese Medicine，Ningxia Medical University，Yinchuan 750004，China

Received:2025-12-08 Accepted:2026-01-08 Online:2026-03-25 Published:2026-04-27
Contact: Yan WANG

Abstract

Abstract:

Fermented soybean is a traditional Chinese medicinal herb with a wide range of applications. It was included in the first batch of medicinal and edible substances catalog in 2002 with high research value and application potential. Studies have found that fermented soybean is rich in organic compounds such as volatile substances， flavonoids， plant polysaccharides， amino acids， and inorganic trace elements， exhibiting pharmacological activities including improving Alzheimer's disease， reducing blood sugar and blood lipids， regulating vascular relaxation， anti osteoporosis， anti-tumor， antioxidant， antiviral， and antidepressant. The systematic review summarized the research progress on the active ingredients and pharmacological effects of fermented soybean， in order to provide a reference for the development and comprehensive resource utilization of fermented soybean.

Key words: fermented soybean, active ingredients, pharmacological action

CLC Number:

Q945.1

Honglin CHEN, Jinjin SHEN, Mengge LI, Yan WANG. Research Progress on the Active Ingredients and Pharmacological Effects of Fermented Soybean Paste[J]. Current Biotechnology, 2026, 16(2): 277-287.

Figures/Tables 1

References 76

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药理作用	对应活性成分
改善阿兹海默症（抑制乙酰胆碱酯酶）	淡豆豉异黄酮总苷元（总苷元>染料木素>黄豆苷元>黄豆黄素）
降血糖	淡豆豉异黄酮（表现：ISSP>淡豆豉>黑豆）
降血脂	异黄酮类成分（表现：ISSP>淡豆豉）
调控血管舒缩（抑制ACE活性）	GABA（与大豆苷元、染料木素无关）
抗骨质疏松	大豆苷元（炮制后苷元含量上升，糖苷含量则降低）
抗肿瘤	大豆苷、大豆苷元、染料木素等（炮制后含量升高）
抗氧化	淡豆豉异黄酮（正丁醇萃取物效果最佳）
抗病毒	大豆苷元（减少炎症因子，缓解肺水肿，降低MPO活性）
抗抑郁	GABA（“再闷”含量迅速增加）
调节肠道	大豆低聚糖（可与有益菌分泌的糖蛋白结合）

药理作用	对应活性成分
改善阿兹海默症（抑制乙酰胆碱酯酶）	淡豆豉异黄酮总苷元（总苷元>染料木素>黄豆苷元>黄豆黄素）
降血糖	淡豆豉异黄酮（表现：ISSP>淡豆豉>黑豆）
降血脂	异黄酮类成分（表现：ISSP>淡豆豉）
调控血管舒缩（抑制ACE活性）	GABA（与大豆苷元、染料木素无关）
抗骨质疏松	大豆苷元（炮制后苷元含量上升，糖苷含量则降低）
抗肿瘤	大豆苷、大豆苷元、染料木素等（炮制后含量升高）
抗氧化	淡豆豉异黄酮（正丁醇萃取物效果最佳）
抗病毒	大豆苷元（减少炎症因子，缓解肺水肿，降低MPO活性）
抗抑郁	GABA（“再闷”含量迅速增加）
调节肠道	大豆低聚糖（可与有益菌分泌的糖蛋白结合）

Research Progress on the Active Ingredients and Pharmacological Effects of Fermented Soybean Paste

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