Fusarium head blight （FHB） is a destructive disease of wheat that reduces yield and grain quality. The urging task of screening for resistance genes and understanding mechanisms underlying FHB resistance will certainly help to win the fight against FHB in the near future. This review expounded systematically the following main sections： QTL for FHB resistance， omics， cell wall fortification， signaling transduction， secondary metabolite synthesis， recognition and resistance mechanism study， and discussed the research direction of FHB resistance mechanism. The review was expected to provide theoretical reserves for further revealing the molecular mechanism on regulating wheat FHB resistance， and provide excellent gene resources for improving wheat FHB germplasm resources.

Fusarium head blight （FHB）， which is major caused by Fusarium graminearum， damages wheat spikes directly. It not only affects the yield of wheat， but also threatens the health of humans and livestock due to contamination of mycotoxin. In recent years， many progresses have been achieved in transcriptomics research on the interaction between wheat and F. graminearum. This review focused on the response of wheat genes upon F. graminearum infection. We mainly compared the gene expression of wheat ears on different varieties， different organs， and different developmental stages during infection. We also summarized the genes differentially expressed in phytohormonal response， signal transduction， transcriptional regulation， and plant defense. The review was expected to facilitate our understanding of how wheat response to F. graminearum infection.

Wheat scab caused by Fusarium graminearum is one of the most important fungal diseases in wheat. In addition to causing serious yield losses， this pathogen also produces a variety of harmful mycotoxins that poses a threat to the health of humans and animals. Protein kinases play important roles in growth， development， pathogenicity and stress responses in F. graminearum. This review summarized the research progress of protein kinases of F. graminearum in biological function and molecular mechanism， and prospected the research trends， in order to provide theoretical references for future research on protein kinases of F. graminearum and the control of wheat scab.

High?throughput proteomics enables the identification and quantitation of protein expression profiles of a specific tissue in wheat. Based on a previous proteomics study on bulked rachides post inoculation with Fusarium graminearum， the current study employed 632 differentially accumulated proteins for co?expression network construction， and the highly correlated modules was proceeded with protein?protein interaction （PPI） analysis， aiming at exploring potential proteins associated with Fusarium head blight （FHB） resistance. Weighted correlation network analysis （WGCNA） constructed a total of 12 modules， module 6 and module 8 were significantly correlated with FHB. The PPI identified seven candidates， and these proteins were connected to detoxification， such as glutathione S?transferase （GST） and S?adenosylmethionine?dependent methyltransferase （AdoMet?MTase）， photosynthesis， such as membrane?associated 30 kD， chloroplastic （IM30）， photosynthetic NDH subcomplex L 2 （PnsL2） and PsbP?like protein 1 （PPL1）， defense response， such as ubiquitin carboxyl?terminal hydrolase （UCHL） and methionine aminopeptidase 2 （MetAP2）. These proteins may play crucial roles in host resistance to FHB， and are worth further explorations.