Abstract: Bacillus licheniformis is a common Grampositive bacterium. It has good features of high heat-resistance, variouse enzyme production, good enzyme productivity, and high safety. It also can produce many kinds of bioactive substances such as polysaccharid, lipopeptide biosurfactant, bacitracin and small molecular substances. This paper summarizes the research progress of bioactive substances produced by Bacillus licheniformis and their biological activity and application, prospects its development direction of new strains construction by means of genetic engineering, so as to provide references for the future utilization of Bacillus licheniformis.

Key words: Bacillus licheniformis, bioactive substances, application.