Research Progress on Effects of Medicinal and Food Homologous Substances on Skin Health

doi:10.19586/j.2095-2341.2025.0191

Current Biotechnology ›› 2026, Vol. 16 ›› Issue (2): 299-308.DOI: 10.19586/j.2095-2341.2025.0191

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Research Progress on Effects of Medicinal and Food Homologous Substances on Skin Health

Ge YAN¹(), Kunlun HUANG¹^,², Tao TONG¹^,²()

^1.College of Food Science and Nutritional Engineering，China Agricultural University，Beijing 100083，China
^2.Key Laboratory of Safety Assessment of Genetically Modified Organism （Food Safety），the Ministry of Agriculture and Rural Affairs，Beijing 100083，China

Received:2025-12-28 Accepted:2026-02-12 Online:2026-03-25 Published:2026-04-27
Contact: Tao TONG

Abstract

Abstract:

With the intensification of population aging， medicinal and food homologous substances， which possess both dietary and medicinal values， have garnered increasing attention in the field of skin health. Current studies have reported the positive effects of various medicinal and food homologous substances in alleviating skin inflammation， promoting wound healing， removing spots and whitening， delaying skin photoaging and natural aging， as well as improving acne. This article systematically reviewed the current research status of medicinal and food homologous substances in improving skin health， and analyzed the active components， efficacy， and molecular mechanisms of representative substances such as licorice， astragalus， poria， and kudzu root. Furthermore， it discussed and prospected future research directions in terms of mechanistic insights， clinical translation potential， and systematic efficacy evaluation. The aim of this paper is to provide a theoretical reference for further research and product development of medicinal and food homologous substances in the field of skin health.

Key words: homology of medicine and food, skin health, physiological activity

CLC Number:

Ge YAN, Kunlun HUANG, Tao TONG. Research Progress on Effects of Medicinal and Food Homologous Substances on Skin Health[J]. Current Biotechnology, 2026, 16(2): 299-308.

Figures/Tables 1

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功效	药食同源物质的活性成分	模型	具体功效	参考文献
减缓银屑病等皮肤炎症	甘草醇	莫喹莫特诱导的小鼠银屑病样模型	通过抗炎抑制银屑病样症状，对 HaCaT细胞有抑制作用并调节相关蛋白表达	[8]
	黄芪甲苷	—	抑制角质形成细胞增殖和炎症，改善银屑病样皮肤损伤	[9]
	当归饮子	莫喹莫特诱导的小鼠银屑病样模型；寻常型银屑病患者临床试验	修复银屑病皮肤屏障，改善多项皮肤功能指标并降低复发率	[10-11]
促进创面愈合	甘草酸二钾	大鼠切除伤口模型；成年和老年大鼠伤口模型	调节炎症促进皮肤伤口愈合，涉及多种细胞因子和组织修复过程	[12-13]
	蜂蜜	大鼠皮肤缺损模型	在皮肤修复不同阶段分别促进炎性细胞分泌、消散炎症、促进组织增生和抑制过度增生	[14]
	环黄芪醇	大鼠糖尿病性皮肤溃疡模型	激活Wnt/β-catenin信号通路促进糖尿病性皮肤溃疡愈合	[15]
祛斑和美白	茯苓总三萜	动物实验	捕获黑色素合成中间体多巴醌,抑制酪氨酸酶	[16]
祛斑和美白	甘草黄酮	黄褐斑患者临床试验	抑制黑色素形成，对黄褐斑有较好治疗效果	[17]
缓解光老化	山楂多酚提取物	紫外线诱导的HaCaT细胞模型和小鼠损伤模型	调节相关表达抑制小鼠皮肤光老化，清除ROS等逆转 UVB 照射影响	[18-20]
	菊花花蕾提取物	紫外线照射的HaCaT等细胞模型和小鼠皮肤光老化模型	调节通路缓解UVB诱导的皮肤光老化，改善皮肤状况	[21]
	茯苓水提物	紫外线诱导的小鼠皮肤损伤模型	通过增加肠道丙酸代谢菌群，修复紫外线照射导致的肠道绒毛损伤和黏液减少，从而改善皮肤的光损伤	[22]
	枸杞多糖组分	紫外线诱导的小鼠皮肤损伤模型	抗表皮增厚和低胶原密度	[23]
抗皮肤衰老	白芷醇提物	D-半乳糖诱导的小鼠亚急性衰老模型	具有抗氧化活性与延缓皮肤衰老相关	[24]
	茯苓提取物	D-半乳糖诱导的衰老大鼠皮肤老化模型	改善皮肤老化，促进胶原积累和透明质酸生成；减轻氧化应激相关的皮肤老化	[25-26]
	葛根	自然衰老小鼠模型	提高总抗氧化能力和羟自由基抑制率，延缓皮肤组织的衰老	[27-28]
	枸杞多糖	D-半乳糖诱导的衰老小鼠皮肤老化模型	提高皮肤含水量、成纤维细胞数及表皮和真皮厚度，延缓衰老	[29]
缓解痤疮	当归芍药散活性成分	油酸+痤疮丙酸杆菌诱导的大鼠耳廓痤疮模型	调控JNK/p38 MAPK信号通路，改善痤疮	[30]
缓解痤疮	茯苓丸合当归须散活性成分	痤疮患者临床试验	青春期后痤疮患者皮损、皮肤油脂增多	[31]

功效	药食同源物质的活性成分	模型	具体功效	参考文献
减缓银屑病等皮肤炎症	甘草醇	莫喹莫特诱导的小鼠银屑病样模型	通过抗炎抑制银屑病样症状，对 HaCaT细胞有抑制作用并调节相关蛋白表达	[8]
	黄芪甲苷	—	抑制角质形成细胞增殖和炎症，改善银屑病样皮肤损伤	[9]
	当归饮子	莫喹莫特诱导的小鼠银屑病样模型；寻常型银屑病患者临床试验	修复银屑病皮肤屏障，改善多项皮肤功能指标并降低复发率	[10-11]
促进创面愈合	甘草酸二钾	大鼠切除伤口模型；成年和老年大鼠伤口模型	调节炎症促进皮肤伤口愈合，涉及多种细胞因子和组织修复过程	[12-13]
	蜂蜜	大鼠皮肤缺损模型	在皮肤修复不同阶段分别促进炎性细胞分泌、消散炎症、促进组织增生和抑制过度增生	[14]
	环黄芪醇	大鼠糖尿病性皮肤溃疡模型	激活Wnt/β-catenin信号通路促进糖尿病性皮肤溃疡愈合	[15]
祛斑和美白	茯苓总三萜	动物实验	捕获黑色素合成中间体多巴醌,抑制酪氨酸酶	[16]
祛斑和美白	甘草黄酮	黄褐斑患者临床试验	抑制黑色素形成，对黄褐斑有较好治疗效果	[17]
缓解光老化	山楂多酚提取物	紫外线诱导的HaCaT细胞模型和小鼠损伤模型	调节相关表达抑制小鼠皮肤光老化，清除ROS等逆转 UVB 照射影响	[18-20]
	菊花花蕾提取物	紫外线照射的HaCaT等细胞模型和小鼠皮肤光老化模型	调节通路缓解UVB诱导的皮肤光老化，改善皮肤状况	[21]
	茯苓水提物	紫外线诱导的小鼠皮肤损伤模型	通过增加肠道丙酸代谢菌群，修复紫外线照射导致的肠道绒毛损伤和黏液减少，从而改善皮肤的光损伤	[22]
	枸杞多糖组分	紫外线诱导的小鼠皮肤损伤模型	抗表皮增厚和低胶原密度	[23]
抗皮肤衰老	白芷醇提物	D-半乳糖诱导的小鼠亚急性衰老模型	具有抗氧化活性与延缓皮肤衰老相关	[24]
	茯苓提取物	D-半乳糖诱导的衰老大鼠皮肤老化模型	改善皮肤老化，促进胶原积累和透明质酸生成；减轻氧化应激相关的皮肤老化	[25-26]
	葛根	自然衰老小鼠模型	提高总抗氧化能力和羟自由基抑制率，延缓皮肤组织的衰老	[27-28]
	枸杞多糖	D-半乳糖诱导的衰老小鼠皮肤老化模型	提高皮肤含水量、成纤维细胞数及表皮和真皮厚度，延缓衰老	[29]
缓解痤疮	当归芍药散活性成分	油酸+痤疮丙酸杆菌诱导的大鼠耳廓痤疮模型	调控JNK/p38 MAPK信号通路，改善痤疮	[30]
缓解痤疮	茯苓丸合当归须散活性成分	痤疮患者临床试验	青春期后痤疮患者皮损、皮肤油脂增多	[31]

Research Progress on Effects of Medicinal and Food Homologous Substances on Skin Health

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