Recent Advances in Biosynthesis and Application of Chlorogenic Acid from Tobacco

doi:10.19586/j.2095-2341.2025.0094

Current Biotechnology ›› 2025, Vol. 15 ›› Issue (6): 933-943.DOI: 10.19586/j.2095-2341.2025.0094

• Reviews • Next Articles

Recent Advances in Biosynthesis and Application of Chlorogenic Acid from Tobacco

Qiang JI(), Na WU, Chao ZHENG, Zhikang SUN, Han WU, Xuanwen LI, Jie HAO()

Inner Mongolia Kunming Cigarette Co. ，Ltd. ，Hohhot 010020，China

Received:2025-07-30 Accepted:2025-09-05 Online:2025-11-25 Published:2026-01-04
Contact: Jie HAO

Abstract

Abstract:

Chlorogenic acid （CGA） is the most abundant polyphenolic compound in tobacco leaves， playing a crucial role in tobacco growth and development as well as cigarette smoke quality. It can serve as a key indicator to evaluate tobacco leaf quality. The biosynthesis and regulation mechanisms of CGA in tobacco have long been the focus of attention among tobacco researchers， while studies on the biological activities of CGA have also extended to fields including medicine， healthcare， and food science. This paper comprehensively reviewed the synthesis pathway， biological activities， and applications of CGA in tobacco， along with the factors influencing CGA biosynthesis in tobacco and the key enzyme genes involved in its synthesis pathway. The aim of this review was to provide a theoretical foundation for the in-depth research， development， and application of CGA metabolic regulation and biological activities in tobacco and other plants.

Key words: tobacco, chlorogenic acid, metabolic regulation, biological activity

摘要：

绿原酸（chlorogenic acid，CGA）是烟叶中含量最多的多酚类物质，在烟草生长发育、烟气质量等方面发挥重要作用，可作为衡量烟叶品质的重要指标。CGA在烟草中的生物合成与调控机制一直是烟草科研工作者关注的焦点，对CGA生物活性方面的研究也已经深入到医药、保健、食品等领域。对烟草中CGA的合成途径、生物活性以及应用、影响烟草中CGA生物合成的因素以及合成途径中的关键酶基因进行了详细综述，以期为烟草等植物中CGA代谢调控及生物活性的深入研究和开发应用提供理论基础。

关键词: 烟草, 绿原酸, 代谢调控, 生物活性

CLC Number:

Q591.9

Qiang JI, Na WU, Chao ZHENG, Zhikang SUN, Han WU, Xuanwen LI, Jie HAO. Recent Advances in Biosynthesis and Application of Chlorogenic Acid from Tobacco[J]. Current Biotechnology, 2025, 15(6): 933-943.

季嫱, 吴娜, 郑超, 孙志康, 吴晗, 李选文, 郝捷. 烟草中绿原酸的生物合成与应用研究进展[J]. 生物技术进展, 2025, 15(6): 933-943.

Figures/Tables 2

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生物活性	作用机制	参考文献
抗菌	↓脂多糖	[7]
	↓群体感应	[8]
	↓琥珀酸脱氢酶/苹果酸脱氢酶	[9]
	↓三羧酸循环、糖酵解	[10]
抗氧化	↑转录因子红细胞衍生2相关因子2信号通路	[11]
	↑过氧化物歧化酶	[12]
	↑牛磺酸上调基因1	[13]
	↓肿瘤抑制因子Keap1	[14]
	↓活性氧	[15]
抗肿瘤	↓抗凋亡基因Bcl-2/Bcl-XL	[16]
	↑促凋亡基因Bax/Bcl-XS/Bad	[15]
	↑p38丝裂原活化蛋白激酶	[17]
	↑抑癌基因p53	[18]
	↑小泛素样修饰物1蛋白	[19]
调节糖代谢和脂代谢	↓糖基化终产物	[20]
	↑胰岛素受体底物	[21]
	↑胰岛素敏感性	[20]
	↑磷脂酰肌醇-3-羟基激酶磷酸化	[22]
	↓转录调节因子SREBP-1c/LXRα	[22]
	↑激素敏感脂肪酶、脂肪甘油三酯脂肪酶	[23]
保护神经系统	↓血管收缩素mRNA表达	[24]
	↑内部皮质醇标志物CD31 mRNA表达	[25]
	↓西罗莫司机械靶蛋白信号通路	[26]

生物活性	作用机制	参考文献
抗菌	↓脂多糖	[7]
	↓群体感应	[8]
	↓琥珀酸脱氢酶/苹果酸脱氢酶	[9]
	↓三羧酸循环、糖酵解	[10]
抗氧化	↑转录因子红细胞衍生2相关因子2信号通路	[11]
	↑过氧化物歧化酶	[12]
	↑牛磺酸上调基因1	[13]
	↓肿瘤抑制因子Keap1	[14]
	↓活性氧	[15]
抗肿瘤	↓抗凋亡基因Bcl-2/Bcl-XL	[16]
	↑促凋亡基因Bax/Bcl-XS/Bad	[15]
	↑p38丝裂原活化蛋白激酶	[17]
	↑抑癌基因p53	[18]
	↑小泛素样修饰物1蛋白	[19]
调节糖代谢和脂代谢	↓糖基化终产物	[20]
	↑胰岛素受体底物	[21]
	↑胰岛素敏感性	[20]
	↑磷脂酰肌醇-3-羟基激酶磷酸化	[22]
	↓转录调节因子SREBP-1c/LXRα	[22]
	↑激素敏感脂肪酶、脂肪甘油三酯脂肪酶	[23]
保护神经系统	↓血管收缩素mRNA表达	[24]
	↑内部皮质醇标志物CD31 mRNA表达	[25]
	↓西罗莫司机械靶蛋白信号通路	[26]

Recent Advances in Biosynthesis and Application of Chlorogenic Acid from Tobacco

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