DNA Tetrahedral Nanostructure and its Application Progress in Biotechnology

doi:10.19586/j.2095-2341.2020.0122

Curr. Biotech. ›› 2020, Vol. 10 ›› Issue (6): 661-667.DOI: 10.19586/j.2095-2341.2020.0122

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DNA Tetrahedral Nanostructure and its Application Progress in Biotechnology

CHEN Shuo, GAO Jiaqi, WANG Di, LONG Yan, LI Liang, ZHANG Xiao

1.School of Life Science and Technology, Changchun University of Science and Technology, Changchun 130022, China;

2.Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China

Received:2020-09-30 Online:2020-11-25 Published:2020-10-16

DNA四面体纳米结构及其在生物技术领域的应用进展

陈硕1,高佳奇1,王迪2,龙艳2,李亮2*,张晓1*

1.长春理工大学生命科学技术学院, 长春 130022；

2.中国农业科学院生物技术研究所, 北京 100081

通讯作者: 李亮 E-mail：liliang@caas.cn；张晓 E-mail：zhangxiao@cust.edu.cn
作者简介:陈硕 E-mail：1254313136@qq.com
基金资助:
国家转基因新品种培育重大专项（2016ZX08012-003）；中央级公益性科研院所基本科研业务费专项（16103920200010）。

Abstract

Abstract: DNA tetrahedral nanostructure is a kind of DNA three-dimensional nanostructure with tetrahedral shape, which is formed by precise and ingenious DNA sequence design, applying the principle of base complementary pairing and automatic hybridization of four single strands. It has good biocompatibility, excellent cell membrane permeability, simple preparation, high yield, adjustable size and dynamics, so it has been widely studied and applied in the fields of microbial identification, medical diagnosis and biosensors. Based on this, DNA tetrahedral nanostructures and their functional modification were introduced, and the application progress of DNA tetrahedral nanostructures in biotechnology was summarized, in order to provide reference for promoting the research of DNA tetrahedral nanostructures and broadening their application fields.

Key words: DNA tetrahedral structure, DNA nanotechnology, microbial identification, medical diagnosis, biosensor

摘要： DNA四面体纳米结构是一种通过精确巧妙的DNA序列设计，应用碱基互补配对的原则，由4条单链自动杂交结合而成的具有四面体形状的DNA三维纳米结构。其具有良好的生物相容性和优异的细胞膜通透性，同时制备较为简单且产率高、尺寸以及动态性均可调节，因而在微生物鉴定、医学诊断和生物传感器等领域得到了广泛的研究与应用。基于此，介绍了DNA四面体纳米结构及其功能化修饰，综述了DNA四面体纳米结构在生物技术领域的应用进展，以期为推动DNA四面体纳米结构的研究、拓宽其应用领域提供参考。

关键词: DNA四面体结构, DNA纳米技术, 微生物鉴定, 医学诊断, 生物传感器

CHEN Shuo1, GAO Jiaqi1, WANG Di2, LONG Yan2, LI Liang2*, ZHANG Xiao1*. DNA Tetrahedral Nanostructure and its Application Progress in Biotechnology[J]. Curr. Biotech., 2020, 10(6): 661-667.

陈硕,高佳奇,王迪,龙艳,李亮,张晓. DNA四面体纳米结构及其在生物技术领域的应用进展[J]. 生物技术进展, 2020, 10(6): 661-667.

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DNA Tetrahedral Nanostructure and its Application Progress in Biotechnology

DNA四面体纳米结构及其在生物技术领域的应用进展

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