Research Progress on Neuroprotective Effects of Betaine

doi:10.19586/j.2095-2341.2024.0163

Current Biotechnology ›› 2025, Vol. 15 ›› Issue (2): 220-225.DOI: 10.19586/j.2095-2341.2024.0163

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Research Progress on Neuroprotective Effects of Betaine

Tianyuan ZHAO(), Jing WANG, Yulu WANG, Chunsen YUAN, Xuechai CHEN()

College of Chemistry and Life Science，Beijing University of Technology，Beijing 100124，China

Received:2024-10-23 Accepted:2025-02-12 Online:2025-03-25 Published:2025-04-29
Contact: Xuechai CHEN

甜菜碱神经保护作用的研究进展

赵天源(), 王菁, 王雨露, 袁春森, 陈薛钗()

北京工业大学化学与生命科学学院，北京 100124

通讯作者: 陈薛钗
作者简介:赵天源 E-mail: zhaoty719@emails.bjut.edu.cn；
基金资助:
国家自然科学基金项目-面上项目(82271283)

Abstract

Abstract:

As a naturally occurring compound， betaine has attracted widespread attention in the field of neuroprotection in recent years. The unique biochemical properties and multiple functions of betaine make it has potential application value in the treatment of neurodegenerative diseases， neuroinflammation and nerve injury. Betaine has the functions of promoting the metabolism of homocysteine， reducing the level of oxidative stress， regulating the expression of γ-aminobutyric acid， etc. It has a therapeutic role in various neurological diseases such as Alzheimer's disease， depression， and Parkinson's disease， with relatively minor side effects. However， current research on the neuroprotective effects of betaine is still in its infancy， and further exploration is needed to understand its mechanism of action and optimal application scenarios. The article reviewed the research progress on the neuro protective effects of betaine， aiming to provide new ideas and methods for the treatment of neurological diseases.

Key words: betaine, neuroprotection, homocysteine, oxidative stress, neurotransmitter

摘要：

甜菜碱作为一种天然存在的化合物，其独特的生物化学特性和多种功能使其在神经退行性疾病、神经炎症以及神经损伤的治疗中具有潜在的应用价值。甜菜碱具有促进同型半胱氨酸代谢，降低氧化应激水平，调节γ-氨基丁酸表达等作用，对包括阿尔茨海默病、抑郁症、帕金森综合征等多种神经系统疾病均起到一定的治疗作用，且不良反应较小。然而，目前关于甜菜碱在神经保护方面的研究尚处于初级阶段，还需要进一步探索其作用机制和最佳应用方案。综述了甜菜碱在神经保护领域的研究进展，以期为神经系统疾病的治疗提供新的思路和方法。

关键词: 甜菜碱, 神经保护, 同型半胱氨酸, 氧化应激, 神经递质

CLC Number:

Q189

Tianyuan ZHAO, Jing WANG, Yulu WANG, Chunsen YUAN, Xuechai CHEN. Research Progress on Neuroprotective Effects of Betaine[J]. Current Biotechnology, 2025, 15(2): 220-225.

赵天源, 王菁, 王雨露, 袁春森, 陈薛钗. 甜菜碱神经保护作用的研究进展[J]. 生物技术进展, 2025, 15(2): 220-225.

Figures/Tables 2

References 33

1	BHATT M, DI IACOVO A, ROMANAZZI T, et al.. Betaine-the dark knight of the brain[J]. Basic Clin. Pharmacol. Toxicol., 2023, 133(5): 485-495.
2	ARUMUGAM M K, PAAL M C, DONOHUE T M J, et al.. Beneficial effects of betaine: a comprehensive review[J/OL]. Biology, 2021, 10(6): 456[2025-02-19]. .
3	张丽芳.甜菜碱调控肝细胞糖脂代谢的机制研究[D].南宁:广西大学,2019.
4	FAN X, ZHANG L, LI H, et al.. Role of homocysteine in the development and progression of Parkinson's disease[J]. Ann. Clin. Transl. Neurol., 2020, 7(11): 2332-2338.
5	闫晗,向瑞,杨吉春,等.同型半胱氨酸代谢与疾病[J].生理科学进展,2023,54(4):290-296.
	YAN H, XIANG R, YANG J C, et al.. Homocysteine metabolism and associated diseases[J]. Prog. Physiol. Sci., 2023, 54(4): 290-296.
6	王文瑞,董敏.辅因子S-腺苷-L-甲硫氨酸甲基类似物及其应用[J].生物工程学报,2023,39(11):4428-4444.
	WANG W R, DONG M. Synthesis and application of the methyl analogues of S-adenosyl-L-methionine[J]. Chin. J. Biotechnol., 2023, 39(11): 4428-4444.
7	ALIREZAEI M, KHOSHDEL Z, DEZFOULIAN O, et al.. Beneficial antioxidant properties of betaine against oxidative stress mediated by levodopa/benserazide in the brain of rats[J]. J. Physiol. Sci., 2015, 65(3): 243-252.
8	余爱丽,赵晋锋,张晏萌,等.猪SsBHMT基因的原核表达及条件优化[J].生物技术进展,2015,5(2):132-136.
	YU A L, ZHAO J F, ZHANG Y M, et al.. Prokaryotic expression and optimization of expression conditions of BHMT gene from Sus scrofa [J]. Curr. Biotechnol., 2015, 5(2): 132-136.
9	VELAZQUEZ R, FERREIRA E, WINSLOW W, et al.. Maternal choline supplementation ameliorates Alzheimer's disease pathology by reducing brain homocysteine levels across multiple generations[J]. Mol. Psychiatry, 2020, 25(10): 2620-2629.
10	DI MECO A, LI J G, BARRERO C, et al.. Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy[J]. Mol. Psychiatry, 2019, 24(11): 1696-1706.
11	HOOSHMAND B, SOLOMON A, KÅREHOLT I, et al.. Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study[J]. Neurology, 2010, 75(16): 1408-1414.
12	TENG Y W, CERDENA I, ZEISEL S H. Homocysteinemia in mice with genetic betaine homocysteine S-methyltransferase deficiency is independent of dietary folate intake[J]. J. Nutr., 2012, 142(11): 1964-1967.
13	CHAI G S, JIANG X, NI Z F, et al.. Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine[J]. J. Neurochem., 2013, 124(3): 388-396.
14	IBI D, TSUCHIHASHI A, NOMURA T, et al.. Involvement of GAT2/BGT-1 in the preventive effects of betaine on cognitive impairment and brain oxidative stress in amyloid β peptide-injected mice[J]. Eur. J. Pharmacol., 2019, 842: 57-63.
15	邱思元,闫立地,赵文婧,等.程序性坏死发生机制在帕金森病中作用的研究进展[J].生物技术进展,2023,13(3):406-411.
	QIU S Y, YAN L D, ZHAO W J, et al.. Research progress on the role of necroptosis development mechanism in Parkinson's disease[J]. Curr. Biotechnol., 2023, 13(3): 406-411.
16	HO P I, ORTIZ D, ROGERS E, et al.. Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage[J]. J. Neurosci. Res., 2002, 70(5): 694-702.
17	MÜLLER T, JUGEL C, EHRET R, et al.. Elevation of total homocysteine levels in patients with Parkinson's disease treated with duodenal levodopa/carbidopa gel[J]. J. Neural Transm., 2011, 118(9): 1329-1333.
18	CORDARO M, SIRACUSA R, FUSCO R, et al.. Involvements of hyperhomocysteinemia in neurological disorders[J/OL]. Metabolites, 2021, 11(1): 37[2025-02-19]. .
19	SILVA D V T, PEREIRA A D, BOAVENTURA G T, et al.. Short-term betanin intake reduces oxidative stress in wistar rats[J/OL]. Nutrients, 2019, 11(9): 1978[2025-02-19]. .
20	NIE C, NIE H, ZHAO Y, et al.. Betaine reverses the memory impairments in a chronic cerebral hypoperfusion rat model[J]. Neurosci. Lett., 2016, 615: 9-14.
21	谷亚齐.甜菜碱通过Wnt/β-catenin通路调控斑马鱼ZF4细胞ROS的机制研究[D].淄博:山东理工大学,2021.
22	KANBAK G, ARSLAN O C, DOKUMACIOGLU A, et al.. Effects of chronic ethanol consumption on brain synaptosomes and protective role of betaine[J]. Neurochem. Res., 2008, 33(3): 539-544.
23	MCCARTY M F, O'KEEFE J H, DINICOLANTONIO J J. A diet rich in taurine, cysteine, folate, B(12) and betaine may lessen risk for Alzheimer's disease by boosting brain synthesis of hydrogen sulfide[J/OL]. Med. Hypotheses, 2019, 132: 109356[2025-02-19]. .
24	CARO A A, CEDERBAUM A I. Antioxidant properties of S-adenosyl-l-methionine in Fe²⁺-initiated oxidations[J]. Free. Radic. Biol. Med., 2004, 36(10): 1303-1316.
25	宋佳,李雪龙,林欣梅,等.罗伊氏粘液乳杆菌HCS02-001培养方法优化及改善睡眠功能研究[J].生物技术进展,2024,14(1):133-140.
	SONG J, LI X L, LIN X M, et al.. Study on optimization of culture method and improvement of sleep function of limosilactobacillus reuteri HCS02-001[J]. Curr. Biotechnol., 2024, 14(1): 133-140.
26	TROUSSELARD M, LEFEBVRE B, CAILLET L, et al.. Is plasma GABA level a biomarker of Post-Traumatic Stress Disorder (PTSD) severity?A preliminary study[J]. Psychiatry Res., 2016, 241: 273-279.
27	KUNISAWA K, KIDO K, NAKASHIMA N, et al.. Betaine attenuates memory impairment after water-immersion restraint stress and is regulated by the GABA ergic neuronal system in the hippocampus[J]. Eur. J. Pharmacol., 2017, 796: 122-130.
28	LEE M, MCGEER E G, MCGEER P L. Mechanisms of GABA release from human astrocytes[J]. Glia, 2011, 59(11): 1600-1611.
29	KEMPSON S A, ZHOU Y, DANBOLT N C. The betaine/GABA transporter and betaine: roles in brain, kidney, and liver[J/OL]. Front. Physiol., 2014, 5: 159[2025-02-19]. .
30	CAI L, TAO Q, LI W, et al.. The anti-anxiety/depression effect of a combined complex of casein hydrolysate and γ-aminobutyric acid on C57BL/6 mice[J/OL]. Front. Nutr., 2022, 9: 971853[2025-02-19]. .
31	KNIGHT L S, PIIBE Q, LAMBIE I, et al.. Betaine in the brain: characterization of betaine uptake, its influence on other osmolytes and its potential role in neuroprotection from osmotic stress[J]. Neurochem. Res., 2017, 42(12): 3490-3503.
32	LEE M B, KOOISTRA M, ZHANG B, et al.. Betaine homocysteine methyltransferase is active in the mouse blastocyst and promotes inner cell mass development[J]. J. Biol. Chem., 2012, 287(39): 33094-33103.
33	SLOW S, LEVER M, CHAMBERS S T, et al.. Plasma dependent and independent accumulation of betaine in male and female rat tissues[J]. Physiol. Res., 2009, 58(3): 403-410.

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Research Progress on Neuroprotective Effects of Betaine

甜菜碱神经保护作用的研究进展

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