Research Progress of Nrf2 in Ferroptosis After Spinal Cord Injury

doi:10.19586/j.2095-2341.2022.0178

Current Biotechnology ›› 2023, Vol. 13 ›› Issue (2): 240-246.DOI: 10.19586/j.2095-2341.2022.0178

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Research Progress of Nrf2 in Ferroptosis After Spinal Cord Injury

Jingyu CAO¹(), Chengmei LIU²(), Chenxu QI¹, Kaiyan DU¹, Meng CHEN¹, Siwei HOU²

^1.Henan University of Chinese Medicine，Zhengzhou 450046，China
^2.The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450099，China

Received:2022-11-03 Accepted:2023-01-06 Online:2023-03-25 Published:2023-04-07
Contact: Chengmei LIU

Abstract

Abstract:

Ferroptosis is one of the important pathological mechanisms of neuronal cell injury after spinal cord injury （SCI）. It has received widespread attention at home and abroad in recent years， but no effective breakthrough has been achieved. In recent years， it has been found that oxidative stress plays an important role in the pathophysiological process. Nuclear factor E2-related factor 2 （Nrf2） has become a hot topic of research because of its anti-oxidative stress effect and involvement in neural repair after SCI， but its mechanism of regulating the development of ferroptosis is still unclear. In this paper， we briefly described the basic structure of Nrf2 and its downstream target genes， introduced the mechanism of ferroptosis and explored the potential role of Nrf2 in SCI treatment， and provided ideas for further study of its relationship with iron death in the development of SCI and explore new strategies for SCI treatment.

Key words: spinal cord injury, ferroptosis, nuclear factor E2-related factor 2, oxidative stress

CLC Number:

R651.2

Jingyu CAO, Chengmei LIU, Chenxu QI, Kaiyan DU, Meng CHEN, Siwei HOU. Research Progress of Nrf2 in Ferroptosis After Spinal Cord Injury[J]. Current Biotechnology, 2023, 13(2): 240-246.

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Research Progress of Nrf2 in Ferroptosis After Spinal Cord Injury

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