Abstract:

As a non-specific drug that interferes with cell cycle， cisplatin is widely used in clinical anti-tumor therapy. However， cisplatin can induce renal cell death and impair renal function. Regulated cell death （RCD） refers to a process of well-controlled programmed cell death with well-defined pathological mechanisms. In recent years， there have been many studies on the cell death modes related to the pathogenesis of various types of acute kidney injury（AKI）， but the role and mechanism of cell death in cisplatin-induced kidney injury remains vacant. Therefore， a comprehensive understanding of the mechanism of cell death in cisplatin-induced nephrotoxicity may provide new therapeutic targets for improving cisplatin-associated nephropathy. This paper summarized the cell death mode in cisplatin-induced kidney injury， including apoptosis， necrotic apoptosis， pyroptosis and ferroptosis， which was expected to provide a possible scheme for the use of cisplatin in tumors therapy with less renal injury.

Key words: cisplatin, kidney injury, apoptosis, necrotic apoptosis, pyroptosis, ferroptosis

摘要：

顺铂作为干预细胞周期的非特异性药物，广泛应用于临床抗肿瘤治疗中，但顺铂可诱导肾细胞死亡，损害肾功能。调节性细胞死亡(regulated all death, RCD)是指具有明确病理机制的受控细胞程序性死亡的过程。近年来，对于各种类型急性肾损伤（acute kidney injury, AKI）发病机制相关的细胞死亡方式研究较多，但细胞死亡在顺铂诱导的肾损伤中的作用及机制研究仍存在空缺。因此，全面了解顺铂诱导的肾毒性中细胞死亡的机制可能会为顺铂诱导的肾病提供新的治疗靶点。综述了顺铂诱导的肾损伤中的细胞死亡方式，包括细胞凋亡、坏死性凋亡、焦亡和铁死亡，以期为在肿瘤治疗中制定降低肾损伤的顺铂用药方案提供参考。

关键词: 顺铂, 肾损伤, 细胞凋亡, 坏死性凋亡, 焦亡, 铁死亡