Abstract:

The RET proto-oncogene is an important cancer driver gene， which is closely related to the occurrence and development of a variety of human tumors. The pathogenesis of RET related tumors includes RET gene activation point mutation and RET gene fusion mutation. In recent years， breakthrough progress has been made in the development of precision targeted drugs for carcinogenic RET gene fusion mutation. In this paper， the research progress of RET related pathogenesis， diagnosis and drug development in recent years were reviewed to provide reference for the accurate diagnosis and treatment of cancer patients with RET gene mutation， and improve the disease remission rate and disease control rate by accurately and efficiently inhibiting RET gene mutation.

Key words: RET, fusion gene, gene mutation, targeted therapy

摘要：

RET原癌基因是一种重要的癌症驱动基因，与人类多种肿瘤的发生、发展密切相关。RET相关肿瘤的发病机制包括RET基因激活性点突变与RET基因融合突变。近年来，针对致癌性RET基因融合突变开发的精准靶向药物取得了突破性进展。综述了RET原癌基因与肿瘤发生、发展相关性研究及近年来临床诊疗方面的研究进展，旨在为RET基因突变癌症患者的精准化诊疗提供参考，并通过精准高效地抑制RET基因突变，提高疾病缓解率和控制率。

关键词: RET, 融合基因, 基因突变, 靶向治疗