Progress in Rabies Virus Glycoprotein and Neutralizing Antibody

doi:10.3969/j.issn.2095-2341.2013.0 .

Curr. Biotech. ›› 2013, Vol. 3 ›› Issue (5): 317-323.DOI: 10.3969/j.issn.2095-2341.2013.0 .

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Progress in Rabies Virus Glycoprotein and Neutralizing Antibody

CHANG Liang, LIU Xiao-zhi, GAO Jian

State Key Laboratory of Antibody Research and Development, New Drug Research and Development Company Ltd., North China Pharmaceutical Corporation, Shijiazhuang 050051, China

Received:2013-05-02 Online:2013-09-25 Published:2013-06-14

狂犬病毒糖蛋白及其中和性抗体研究进展

常亮,刘晓志,高健

华北制药集团新药研究开发有限责任公司, 抗体药物研制国家重点实验室, 石家庄 050015

作者简介:常亮，工程师，博士，研究方向为生化与分子生物学。E-mail:changliang1981@gmail.com
基金资助:
国家975项目“生物活性分子结构和功能的关系研究”（2012CB724500）资助。

Abstract

Abstract: Rabies is a fatal zoonosis caused by rabies virus (RV). Rabies virus glycoprotein (RVG), the unique viral protein exposed on the surface of viral envelope, can induce the production of rabies neutralizing antibodies. This review focuses on recent advances in rabies virus, the structure and function of glycoprotein, progress of neutralizing antibodies and their action mechanism, which can provide theoretical foundations and development strategies for further study of neutralizing antibodies.

Key words: rabies virus, glycoprotein, neutralizing antibody, mechanism

摘要： 狂犬病是一种由狂犬病毒引发的高致命人兽共患传染病，狂犬病毒糖蛋白作为唯一暴露于包膜外的病毒蛋白可有效诱生中和性抗体。本文介绍了狂犬病毒及其糖蛋白结构与功能，全面综述了狂犬病毒中和抗体研究进展及其作用机制，为中和抗体的深入研究提供理论基础和研发策略。

关键词: 狂犬病毒, 糖蛋白, 中和抗体, 作用机制

CHANG Liang, LIU Xiao-zhi, GAO Jian. Progress in Rabies Virus Glycoprotein and Neutralizing Antibody[J]. Curr. Biotech., 2013, 3(5): 317-323.

常亮,刘晓志,高健. 狂犬病毒糖蛋白及其中和性抗体研究进展[J]. 生物技术进展, 2013, 3(5): 317-323.

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Progress in Rabies Virus Glycoprotein and Neutralizing Antibody

狂犬病毒糖蛋白及其中和性抗体研究进展

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