Curr. Biotech. ›› 2017, Vol. 7 ›› Issue (2): 106-110.DOI: 10.3969/j.issn.2095-2341.2017.02.04

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Progress of Biosynthesis Mechanism and Genetic Engineering of Salidroside

HUANG Lina, LIU Huan, ZHANG Fenqiang, JIANG Mengyan, YU Yue, ZHOU Yijie, ZHOU Wangyan, XUE Feiyan, MA Lanqing,   

  1. 1.Key Laboratory of Urban Agriculture (North China), Ministry of Agriculture, College of Biological Science and Engineering, Beijing University of Agriculture, Beijing 102206, China;
    2.Key Laboratory of Urban Agriculture (North China), Ministry of Agriculture, Plant Science and Technology College, Beijing University of Agriculture, Beijing 102206, China;
    3.Beijing Collaborative Innovation Center for Eco-environmental Improvement with Forestry and  Fruit Trees, Beijing University of Agriculture, Beijing 102206, China
  • Received:2016-11-16 Online:2017-03-25 Published:2016-12-16

红景天苷生物合成机制及其基因工程研究进展

黄丽娜1,刘欢2,张奋强2,姜梦嫣1,于跃1,周义杰2,周王艳1,薛飞燕 1*,马兰青1,3*   

  1. 1.北京农学院生物科学与工程学院, 农业部华北都市农业重点实验室, 北京 102206;
    2.北京农学院植物科学技术学院, 农业部华北都市农业重点实验室, 北京 102206;
    3.北京农学院, 北京林果业生态环境功能提升协同创新中心, 北京 102206
  • 通讯作者: 薛飞燕，讲师，研究方向为生物发酵。E-mail：feiyanxue@bua.edu.cn；马兰青，教授，研究方向为植物次生代谢分子调控。E-mail: lqma@bac.edu.cn
  • 作者简介:黄丽娜，硕士研究生，研究方向为细胞代谢工程。E-mail:buguxing@126.com。
  • 基金资助:
    国家自然科学基金项目(21606020);北京市自然科学基金项目(2164059);北京市优秀人才资助项目(2013D05021000003);北京市科技创新服务能力建设-协同创新中心项目（PXM2017_014207_000043）资助。

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Abstract: Salidroside, mainly from Rhodiola rosea, is an important active substance from Rhodiola plants and has diversified medicinal efficacy such as radiation resistance, hypoxia resistance, tumor resistance, etc. Because of limited source of wild Rhodiola  rosea, extremely low ratio of Salidroside in Rhodiola rosea  and low extraction rate of Salidroside, it is important and valuable to study production methods that could increase the output of Salidroside. Studying on Salidroside biosynthesis mechanism and using genetic engineering techniques to increase the output of Salidroside would have certain extent of promising prospect and value of study. This paper gave an overview of Salidroside biosynthesis mechanism, key enzymes in the metabolic pathway and the Salidroside synthesis method by means of metabolic engineering, followed by proposing the prospect of this study, which was expected to provide reference for research on Salidroside biosynthesis.

Key words: salidroside, key enzymes, metabolic engineering

摘要： 红景天苷主要来源于红景天，是红景天属植物的重要活性物质，具有抗辐射、抗缺氧、抗肿瘤等多种药用功效。由于红景天野生资源少，且红景天苷在红景天中含量极少、提取率低，因此，研究提高红景天苷产量的生产方法具有重要的意义和价值。在研究红景天苷生物合成机制的基础上，通过基因工程技术来提高红景天苷的产量具有一定的前景和研究价值。综述了红景天苷的生物合成机制、代谢途径中的关键酶和利用代谢工程合成红景天苷的方法，并对其研究前景进行了展望，以期为红景天苷的生物合成相关研究提供参考。

关键词: 红景天苷, 关键酶, 代谢工程

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