Abstract: Selenium(Se) is an important trace element for human health. The paper summarized the advances of Se metabolism and nutrition in human, covering selenium in food and absorption, concentration and distribution in human body, selenium metabolism pathway, biological activated form disease, selenium toxicity and safe daily selenium intake. On this base, Se intake research based on synthetic evaluation including distribution of selenium resources and Se reaction disease, dietary structure in china was suggested for further theoretical and practical guidance on disease control and prevention through selenium supplement.

Key words: selenium, metabolism, daily intake, selenoprotein, selenium toxicity

摘要： 硒是人体所必需的重要微量营养元素，综述了当前国内外人体硒代谢与硒营养的研究进展，包括硒源形式与吸收、人体的硒含量与分布、硒的代谢途径、硒的生物活化形式、硒与疾病、硒中毒和硒的安全摄入量。在此基础上，提出了针对我国硒资源分布、硒反应症分布和居民膳食结构硒摄入量的研究建议，为满足居民通过膳食和补充剂补硒预防和治疗疾病提供理论和实践指导。

关键词: 硒, 代谢, 摄入量, 硒蛋白, 硒中毒