Progress on Glycoprotein Hormones

doi:10.3969/j.issn.2095-2341.2015.01.03

Curr. Biotech. ›› 2015, Vol. 5 ›› Issue (1): 22-28.DOI: 10.3969/j.issn.2095-2341.2015.01.03

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Progress on Glycoprotein Hormones

CHANG Liang, LI Chen-hui, MA Zhi-jun, ZHAO Jing, GAO Jian

State Key Laboratory of Antibody Research and Development, New Drug Research and Development Co. Lt., North China Pharmaceutical Corporation, Shijiazhuang 050051, China

Received:2014-10-09 Online:2015-01-25 Published:2014-10-24

糖蛋白激素研究进展

常亮,李晨辉,马志珺,赵静,高健*

华北制药集团新药研究开发有限责任公司, 抗体药物研制国家重点实验室, 石家庄 050015

通讯作者: 高健，高级工程师，主要从事蛋白药物研究。E-mail：gaojian1972@aliyun.cn
作者简介:常亮，工程师，主要从事蛋白药物研究。E-mail：15511802735@163.com。
基金资助:
国家863计划项目(2012AA02A306)资助。

Abstract

Abstract: Glycoprotein hormone (GPH) is a kind of important human hormones family, which consist of four members of—FSH, LH, CG and TSH. The structures of these GPHs are similar, but the functions are different. This paper mainly reviewed on the structure, subunits assembly, receptors recognition, and long-acting engineering of glycoprotein hormones.

Key words: glycoprotein hormone, structure, receptor recognition, long-acting engineering

摘要： 糖蛋白激素是人体内一类重要激素家族，由4个成员构成—促卵泡激素(FSH)、促黄体素(LH)、促甲状腺激素(TSH)和绒毛膜促性腺激素（CG）。这些激素结构相似，但功能各异。主要从结构方面对糖蛋白激素的亚基装配、受体识别及长效化改造进行分析综述。

关键词: 糖蛋白激素, 结构, 受体识别, 长效化改造

CHANG Liang, LI Chen-hui, MA Zhi-jun, ZHAO Jing, GAO Jian*. Progress on Glycoprotein Hormones[J]. Curr. Biotech., 2015, 5(1): 22-28.

常亮,李晨辉,马志珺,赵静,高健. 糖蛋白激素研究进展[J]. 生物技术进展, 2015, 5(1): 22-28.

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Progress on Glycoprotein Hormones

糖蛋白激素研究进展

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