Abstract: Antibiotics are widely used in animal husbandry due to their outstanding functions, including promoting animal growth, improving feed conversion efficiency, and preventing and treating animal diseases. However, only a small amount of antibiotics can be absorbed and degraded by animals, and most of the ingested veterinary antibiotics are excreted into the environment through feces and urine in the form of prototype or antibacterial metabolites. Apart from antibiotics, manure is also a reservoir of antibiotic resistance genes (ARGs) which contains numerous antibiotic resistant bacteria. Antibiotics and ARGs in the manure can transmit in the environment with the application of manure. Furthermore, residual antibiotics can further enrich ARGs in the environment. It has the potential harm to the human health and ecosystem. Based on this situation, environmental fate of antibiotics and ARGs in animal manure was summarized in order to provide a scientific reference for studying the harm of antibiotics and ARGs to ecosystem and human health.

Key words: animal manure, antibiotics, antibiotic resistance genes, fate

摘要： 抗生素因具有促进动物生长、提高饲料转化效率、预防治疗动物疾病等作用而被大量用于畜牧业。然而仅有少量抗生素可被动物吸收降解，其余大部分抗生素以原型或有抗菌活性的代谢产物的形式通过粪尿排入环境。除抗生素外，动物粪便中还含有大量的耐药细菌，是巨大的耐药基因（antibiotic resistance genes，ARGs）库。残留于动物粪便中的抗生素和耐药基因通过动物粪便的施用而在环境中传播，并且残留的抗生素能进一步富集环境中的耐药基因。这对人类健康及生态系统存在着潜在危害。基于此，对畜禽粪污源抗生素及耐药基因在环境中的归趋进行综述，以期为研究畜禽粪污源抗生素及耐药基因对生态系统及人类健康的危害提供科学参考。

关键词: 畜禽粪便, 抗生素, 耐药基因, 归趋