药食同源物质对皮肤健康影响的研究进展

doi:10.19586/j.2095-2341.2025.0191

生物技术进展 ›› 2026, Vol. 16 ›› Issue (2): 299-308.DOI: 10.19586/j.2095-2341.2025.0191

• 进展评述 • 上一篇

药食同源物质对皮肤健康影响的研究进展

严格¹(), 黄昆仑¹^,², 仝涛¹^,²()

^1.中国农业大学食品科学与营养工程学院，北京 100083
^2.农业农村部农业转基因生物安全评价（食用）重点实验室，北京 100083

收稿日期:2025-12-28 接受日期:2026-02-12 出版日期:2026-03-25 发布日期:2026-04-27
通讯作者: 仝涛
作者简介:严格 E-mail: 13520723160@163.com；
基金资助:
山东省自然科学基金项目(ZR2021QC118);2025年保山市科技计划项目(2025bskj09)

Research Progress on Effects of Medicinal and Food Homologous Substances on Skin Health

Ge YAN¹(), Kunlun HUANG¹^,², Tao TONG¹^,²()

^1.College of Food Science and Nutritional Engineering，China Agricultural University，Beijing 100083，China
^2.Key Laboratory of Safety Assessment of Genetically Modified Organism （Food Safety），the Ministry of Agriculture and Rural Affairs，Beijing 100083，China

Received:2025-12-28 Accepted:2026-02-12 Online:2026-03-25 Published:2026-04-27
Contact: Tao TONG

摘要/Abstract

摘要：

随着人口老龄化的加剧，药食同源物质兼具食用与药用价值，在皮肤健康领域受到日益关注。目前，已有研究报道了多种药食同源物质在缓解皮肤炎症、促进创面愈合、美白祛斑、延缓皮肤光老化与自然老化以及改善痤疮等方面的积极作用。系统梳理了药食同源物质在改善皮肤健康方面的研究现状，分析了代表性药食同源物质（如甘草、黄芪、茯苓、葛根等）的活性成分、功效作用和分子机制，并在机制解析、临床转化潜力及系统性功效评价方面对未来的研究方向进行了讨论和展望，旨在为药食同源物质在皮肤健康领域的深入研究和产品开发提供理论参考。

关键词: 药食同源物质, 皮肤健康, 生理活性

Abstract:

With the intensification of population aging， medicinal and food homologous substances， which possess both dietary and medicinal values， have garnered increasing attention in the field of skin health. Current studies have reported the positive effects of various medicinal and food homologous substances in alleviating skin inflammation， promoting wound healing， removing spots and whitening， delaying skin photoaging and natural aging， as well as improving acne. This article systematically reviewed the current research status of medicinal and food homologous substances in improving skin health， and analyzed the active components， efficacy， and molecular mechanisms of representative substances such as licorice， astragalus， poria， and kudzu root. Furthermore， it discussed and prospected future research directions in terms of mechanistic insights， clinical translation potential， and systematic efficacy evaluation. The aim of this paper is to provide a theoretical reference for further research and product development of medicinal and food homologous substances in the field of skin health.

Key words: homology of medicine and food, skin health, physiological activity

中图分类号:

严格, 黄昆仑, 仝涛. 药食同源物质对皮肤健康影响的研究进展[J]. 生物技术进展, 2026, 16(2): 299-308.

Ge YAN, Kunlun HUANG, Tao TONG. Research Progress on Effects of Medicinal and Food Homologous Substances on Skin Health[J]. Current Biotechnology, 2026, 16(2): 299-308.

图/表 1

参考文献 65

[1]	单峰,黄璐琦,郭娟,等.药食同源的历史和发展概况[J].生命科学,2015,27(8):1061-1069.
	SHAN F, HUANG L Q, GUO J, et al.. History and development of “one root of medicine and food”[J]. Chin. Bull. Life Sci., 2015, 27(8): 1061-1069.
[2]	丁劲文,迟湘胤,张玉,等.“食药同源”的生物学原理[J].药学学报,2024,59(6):1509-1518.
	DING J W, CHI X Y, ZHANG Y, et al.. Biological principles of “food and medicine homologous”[J]. Acta Pharm. Sin., 2024, 59(6): 1509-1518.
[3]	余强,郑冰,聂少平,等.“食药同源”食品产业现状与发展趋势浅析[J].中国食品学报,2023,23(9):1-11.
	YU Q, ZHENG B, NIE S P, et al.. An overview and analysis of the current status and trends in the ‘food and medicine homology’ food industry[J]. J. Chin. Inst. Food Sci. Technol., 2023, 23(9): 1-11.
[4]	LIU Y, WU Y, YANG G. Editorial: the nutritional immunological effects and mechanisms of extracts and metabolites based on the homology of medicine and food, volume Ⅱ[J/OL]. Front. Nutr., 2025, 12: 1575234[2026-01-22]. .
[5]	EDO G I, NDUDI W, MAKIA R S, et al.. Nutritional immunological effects and mechanisms of chemical constituents from the homology of medicine and food[J]. Phytochem. Rev., 2025, 24(5): 4183-4217.
[6]	YI Y, QIN S, DING S, et al.. Polysaccharides in the medicine and food homology to combat obesity via gut-liver axis: a review of possible mechanisms[J/OL]. Int. J. Biol. Macromol., 2025, 312: 144044[2026-01-22]. .
[7]	FRANCO A C, AVELEIRA C, CAVADAS C. Skin senescence: mechanisms and impact on whole-body aging[J]. Trends Mol. Med., 2022, 28(2): 97-109.
[8]	LIU Y, FU Y, ZHU Z, et al.. Glycyrol prevents the progression of psoriasis-like skin inflammation via immunosuppressive and anti-inflammatory actions[J/OL]. Int. J. Mol. Sci., 2023, 24(24): 17335[2026-01-22]. .
[9]	LIU T, AI L, JIANG A, et al.. Astragaloside IV suppresses the proliferation and inflammatory response of human epidermal keratinocytes and ameliorates imiquimod-induced psoriasis-like skin damage in mice[J]. Allergol. Immunopathol., 2024, 52(5): 44-50.
[10]	韩盈盈,徐曦,王景乐,等.紫草素联合当归饮子方调控IL-23/IL-17轴对咪喹莫特诱导银屑病样小鼠模型的保护作用[J].中国皮肤性病学杂志,2022,36(10):1137-1143.
	HAN Y Y, XU X, WANG J L, et al.. Protective effect of shikonin combined with dangguiyinzi decoction on imiquimote-induced psoriasis in mice by regulating IL-23/IL-17 axis[J]. Chin. J. Dermatovenereol., 2022, 36(10): 1137-1143.
[11]	李芳梅,杨志波,曾宪玉.当归饮子对寻常型银屑病患者皮肤屏障功能的影响[J].中医药导报,2014,20(7):11-13.
	LI F M, YANG Z B, ZENG X Y. Influence of Chinese Angelica drink on skin function of psoriasis vulgaris[J]. Guid. J. Tradit. Chin. Med. Pharmacol., 2014, 20(7): 11-13.
[12]	DOS SANTOS LEITE C, BONAFÉ G A, PIRES O C, et al.. Dipotassium glycyrrhizininate improves skin wound healing by modulating inflammatory process[J/OL]. Int. J. Mol. Sci., 2023, 24(4): 3839[2026-01-22]. .
[13]	DOS SANTOS LEITE C, PIRES O C, TENIS D G, et al.. Effects of dipotassium glycyrrhizinate on wound healing[J/OL]. Acta Cir. Bras., 2021, 36(8): e360801[2026-01-22]. .
[14]	敖薪,黄涛.蜂蜜对创伤大鼠皮肤修复的作用及其机制的探讨[J].长江大学学报(自然科学版),2019,16(9):83-88.
	AO X, HUANG T. Effect of honey on skin repair in traumatic rats and its mechanism[J]. J. Yangtze Univ. Nat. Sci. Ed., 2019, 16(9): 83-88.
[15]	高琼.黄芪甲苷调控TGF-β1/Smad2/3通路改善高糖损伤的皮肤修复细胞的功能[D].兰州:兰州大学,2023.
[16]	HU S H, ZHOU G, WANG Y W. Tyrosinase inhibitory activity of total triterpenes and poricoic acid a isolated from Poria cocos [J]. Chin. Herb. Med., 2017, 9(4): 321-327.
[17]	HEO H S, HAN G E, WON J, et al.. Pueraria Montana var. Lobata root extract inhibits photoaging on skin through Nrf2 pathway[J]. J. Microbiol. Biotechnol., 2019, 29(4): 518-526.
[18]	LIU S, SUI Q, ZOU J, et al.. Protective effects of hawthorn (Crataegus pinnatifida) polyphenol extract against UVB-induced skin damage by modulating the p53 mitochondrial pathway in vitro and in vivo [J/OL]. J. Food Biochem., 2019, 43(2): e12708[2026-01-22]. .
[19]	LIU S, YOU L, ZHAO Y, et al.. Hawthorn polyphenol extract inhibits UVB-induced skin photoaging by regulating MMP expression and type I procollagen production in mice[J]. J. Agric. Food Chem., 2018, 66(32): 8537-8546.
[20]	BENABDERRAHMANE W, LORES M, BENAISSA O, et al.. Polyphenolic content and bioactivities of Crataegus oxyacantha L. (Rosaceae)[J]. Nat. Prod. Res., 2021, 35(4): 627-632.
[21]	XU S, SUN X, ZHU Z, et al.. The extract of buds of Chrysanthemum morifolium Ramat alleviated UVB-induced skin photoaging by regulating MAPK and Nrf2/ARE pathways[J/OL]. J. Ethnopharmacol., 2024, 332: 118352[2026-01-22]. .
[22]	ZHANG T, HUANG S, QIU J, et al.. Beneficial effect of Gastrodia elata blume and Poria cocos wolf administration on acute UVB irradiation by alleviating inflammation through promoting the gut-skin axis[J/OL]. Int. J. Mol. Sci., 2022, 23(18): 10833[2026-01-22]. .
[23]	NEVES L M G, TIM C R, FLORIANO E M, et al.. Lycium barbarum polysaccharide fraction associated with photobiomodulation protects from epithelium thickness and collagen fragmentation in a model of cutaneous photodamage[J]. Lasers Med. Sci., 2021, 36(4): 863-870.
[24]	王方,王灿.白芷醇提物延缓皮肤衰老与抗氧化作用的相关性研究[J].中国药房,2012,23(7):599-602.
	WANG F, WANG C. Study on the relationship between the anti-aging function and antioxidation of ethanol extract from Angelicoe dahuricae Radix[J]. China Pharm., 2012, 23(7): 599-602.
[25]	CHAO C L, KUO H P, HUANG H W, et al.. Poria cocos lanostane triterpenoids extract promotes collagen and hyaluronic acid production in D-galactose-induced aging rats[J/OL]. Life, 2023, 13(11): 2130[2026-01-22]. .
[26]	FANG C L, PAUL C R, DAY C H, et al.. Poria cocos (Fuling) targets TGFβ/Smad7 associated collagen accumulation and enhances Nrf2-antioxidant mechanism to exert anti-skin aging effects in human dermal fibroblasts[J]. Environ. Toxicol., 2021, 36(5): 729-736.
[27]	XIN C, JIA P, ZHAO Y, et al.. Antioxidant effects of Gastrodia elata polysaccharide-based hydrogels loaded with puerarin/gelatin microspheres for D-galactose-induced aging-skin wound healing[J/OL]. Int. J. Biol. Macromol., 2025, 296: 139809[2026-01-22]. .
[28]	郑伟.葛根及葛根素对衰老小鼠皮肤总抗氧化能力和羟自由基抑制率影响的实验研究[D].沈阳:辽宁中医药大学,2012.
[29]	王彩霞.枸杞多糖对D-半乳糖诱导衰老小鼠皮肤的影响[J].中国老年学杂志,2015,35(22):6360-6362.
	WANG C X. Effect of Lycium barbarum polysaccharides on skin of D-galactose-induced aging mice[J]. Chin. J. Gerontol., 2015, 35(22): 6360-6362.
[30]	陈功珍,杨雨齐,刘鑫,等.当归芍药散加味调控JNK/p38 MAPK通路改善痤疮炎症和凋亡的机制[J].中国实验方剂学杂志,2025,31(5):31-40.
	CHEN G Z, YANG Y Q, LIU X, et al.. Mechanism of modified Danggui Shaoyaosan in improving inflammation and apoptosis in acne via regulating JNK/p38 MAPK pathway[J]. Chin. J. Exp. Tradit. Med. Formulae, 2025, 31(5): 31-40.
[31]	屠远辉,方玉甫,王丽.茯苓丸合当归须散加减治疗痰瘀互结型青春期后痤疮的临床研究[J].时珍国医国药,2020,31(8):1927-1929.
	TU Y H, FANG Y F, WANG L. Clinical study on Fuling pill combined with Danggui Xusan in the treatment of post-adolescent acne with phlegm and blood stasis[J]. Lishizhen Med. Mater. Med. Res., 2020, 31(8): 1927-1929.
[32]	唐雪阳,谢果珍,周融融,等.药食同源的发展与应用概况[J].中国现代中药,2020,22(9):1428-1433.
	TANG X Y, XIE G Z, ZHOU R R, et al.. Development and application of “one root of medicine and food”[J]. Mod. Chin. Med., 2020, 22(9): 1428-1433.
[33]	黄丹,陈崑.银屑病相关流行病学调查进展[J].诊断学理论与实践,2021,20(1):48-52.
	HUANG D, CHEN K. Advances in epidemic study on psoriasis[J]. J. Diagn. Concepts Pract., 2021, 20(1): 48-52.
[34]	张柂儇,刘海龙,王瑞琼,等.黄芪化学成分和药理作用及Q-marker预测分析[J].中国新药杂志,2023,32(4):410-419.
	ZHANG Y X, LIU H L, WANG R Q, et al. Chemical constituents and pharmacological effects of Astragali radix and predictive analysis on quality markers[J]. Chin. J. New Drugs, 2023, 32(4): 410-419.
[35]	JODIDIO M, SCHWARTZ R A. Honey therapies for dermatological disorders: more than just a sweet elixir[J]. Int. J. Dermatol., 2024, 63(4): 422-430.
[36]	姑丽斯坦·阿不都热西提,阿斯亚·麦麦吐逊,阿依姆妮萨·阿卜杜热合曼.黄芪注射液对糖尿病下肢皮肤溃疡患者血清炎症指标及氧化应激指标的影响[J].现代中西医结合杂志,2020,29(30):3393-3396.
[37]	XIONG Y, TANG R, XUELIN L I, et al.. Effect of Neibu Huangqi Youhua formula on postoperative wound healing, inflammatory factors and pain mediators of anal fistula[J]. J. Tradit. Chin. Med., 2025, 45(3): 628-632.
[38]	许洪玲,张磊,陈晗,等.基于Wnt/β-catenin信号通路探讨环黄芪醇对糖尿病性皮肤溃疡模型大鼠创面愈合的作用[J].中药药理与临床,2024,40(6):59-66.
	XU H L, ZHANG L, CHEN H, et al.. Effect of cycloastragenol on wound healing of diabetic skin ulcers in rats based on Wnt/β-catenin pathway[J]. Pharmacol. Clin. Chin. Mater. Med., 2024, 40(6): 59-66.
[39]	LEE H, CHA H J. Poria cocos Wolf extracts represses pigmentation in vitro and in vivo [J]. Cell. Mol. Biol., 2018, 64(5): 80-84.
[40]	李镓汕,殷琼,谢彬,等.中药祛斑美白作用机制研究进展[J/OL].时珍国医国药,2026,37(2):321-330.
	LI J S, YIN Q, XIE B, et al.. Research progress on the mechanism of traditional Chinese medicine in removing spots and whitening[J]. J. Li-shizhen Trad. Chin. Med.,2026, 37(2): 321-330.
[41]	傅国强,马鹏程,吴勤学,等.196味中药乙醇提取物对酪氨酸酶的抑制作用[J].中华皮肤科杂志,2003,36(2):103-106.
	FU G Q, MA P C, WU Q X, et al.. Inhibitory effects of ethanolic extracts from 196 kind of Chinese herbs on tyrosinase[J]. Chin. J. Dermatol., 2003, 36(2): 103-106.
[42]	王明利,李春明,董萍,等.甘草黄酮治疗黄褐斑临床疗效观察[J].辽宁药物与临床,2003,6(3):128-129.
	WANG M L, LI C M, DONG P, et al.. Clinical observation on treatment of chloasma with licorice flavonoids[J]. Liaoning Pharm. Clin. Rehedies, 2003, 6(3): 128-129.
[43]	HOSEINSALARI A, ATAPOUR-MASHHAD H, ASILI J, et al.. Preparation and characterization of nanostructured lipid carriers (NLCs) containing Glycyrrhiza glabra extract for the treatment of skin hyperpigmentation[J]. Curr. Pharm. Des., 2024, 30(40): 3213-3232.
[44]	丁苗苗,魏玲,陈春玉,等.中药活性成分抗皮肤光老化作用及机制研究进展[J].中国中药杂志,2022,47(14):3709-3717.
	DING M M, WEI L, CHEN C Y, et al.. Anti-photoaging effects and mechanisms of active ingredients of Chinese medicine: a review[J]. Zhongguo Zhongyao Zazhi, 2022, 47(14): 3709-3717.
[45]	MA L, HUANG M, SUN G, et al.. Puerariae lobatae Radix protects against UVB-induced skin aging via antagonism of REV-ERBα in mice[J/OL]. Front. Pharmacol., 2022, 13: 1088294[2026-01-22]. .
[46]	CHEN B, LI R, YAN N, et al.. Astragaloside Ⅳ controls collagen reduction in photoaging skin by improving transforming growth factor-β/Smad signaling suppression and inhibiting matrix metalloproteinase-1[J]. Mol. Med. Rep., 2015, 11(5): 3344-3348.
[47]	陈刚,陈斌,吕中明,等.黄芪甲苷乳膏对光老化小鼠皮肤组织MDA含量及SOD、GSH-px活力的影响[J].中国中西医结合皮肤性病学杂志,2010,9(2):71-74.
	CHEN G, CHEN B, LYU Z M, et al.. Change of malondialdehyde, superoxide dismutase and glutathione peroxidase in photo-aging mice skin caused by topical astragaloside cream[J]. Chin. J. Dermatovenerol. Integr. Tradit. West. Med., 2010, 9(2): 71-74.
[48]	KUMAR A, ARCHO S, SINGH C P, et al.. Photoprotective effect of 18β-glycyrrhetinic acid derivatives against ultra violet (UV)-B-induced skin aging[J/OL]. Bioorg. Med. Chem. Lett., 2022, 76: 128984[2026-01-22]. .
[49]	DE MOURA J P, DE MOURA FERNANDES É P, LUSTOZA RODRIGUES T C M, et al.. Targets involved in skin aging and photoaging and their possible inhibitors: a mini-review[J]. Curr. Drug Targets, 2023, 24(10): 797-815.
[50]	ZOUBOULIS C C, GANCEVICIENE R, LIAKOU A I, et al.. Aesthetic aspects of skin aging, prevention, and local treatment[J]. Clin. Dermatol., 2019, 37(4): 365-372.
[51]	高瑞英,党志,邹颖楠,等.当归提取物抗皮肤衰老及美白功效体外实验研究[J].时珍国医国药,2010,21(4):874-875.
	GAO R Y, DANG Z, ZOU Y N, et al.. Experimental study on anti-aging and whitening effects of Angelica sinensis extract in vitro [J]. Lishizhen Med. Mater. Med. Res., 2010, 21(4): 874-875.
[52]	秦聪聪,李玉清.白芷挥发油化学成分和药理作用研究进展[J].中华中医药学刊,2025,43(11):90-97.
	QIN C C, LI Y Q. Research progress on chemical constituents and pharmacological effects of volatile oil from Baizhi (Radix angelicae dahuricae)[J]. Chin. Arch. Tradit. Chin. Med., 2025, 43(11): 90-97.
[53]	FUSTER V. Changing demographics: a new approach to global health care due to the aging population[J]. J. Am. Coll. Cardiol., 2017, 69(24): 3002-3005.
[54]	LYNCH B, PAGEON H, LE BLAY H, et al.. A mechanistic view on the aging human skin through ex vivo layer-by-layer analysis of mechanics and microstructure of facial and mammary dermis[J/OL]. Sci. Rep., 2022, 12(1): 849[2026-01-22]. .
[55]	WANG J, WANG Z, HU J, et al.. Antimicrobial and antioxidant hydrogels based on the water-insoluble β-glucan from Poria cocos loaded with total flavonoids of Ampelopsis grossedentata [J/OL]. ChemistrySelect, 2024, 9(44): e202403057[2026-01-22]. .
[56]	赵丹,李萌,苏宁,等.枸杞发酵液的抗衰老活性和皮肤安全性研究[J].日用化学品科学,2016,39(6):24-27.
	ZHAO D, LI M, SU N, et al.. Evaluation of anti-aging activity and skin safety of fermented Lycium barbarum [J]. Deterg. Cosmet., 2016, 39(6): 24-27.
[57]	WILLIAMS H C, DELLAVALLE R P, GARNER S. Acne vulgaris[J]. Lancet, 2012, 379(9813): 361-372.
[58]	李东影.痤疮炎症标志物的确定及痰热清抑菌凝胶抗痤疮药效机制研究[D].北京:中国中医科学院,2024.
[59]	GAN J, WU C, LI W, et al.. Exploration on molecular mechanism of Lonicerae japonicae Flos-forsythiae fructus herbal pair in traeting acne vulgaris based on network pharmacology and molecular docking technology[J]. MEDS Chin. Med. 2022 4(1): 54-64..
[60]	朱亚芳,赵浩如.中药体外抑制痤疮丙酸杆菌的活性测定[J].药学与临床研究,2009,17(3):224-226.
	ZHU Y F, ZHAO H R. In vitro antimicrobial activities of traditional Chinese medcine to Propionibacterium acnes [J]. Pharm. Clin. Res., 2009, 17(3): 224-226.
[61]	GAN J, WU C, LI W, et al.. Exploration on molecular mechanism of Lonicerae japonicae Flos-forsythiae fructus herbal pair in traeting acne vulgaris based on network pharmacology and molecular docking technology[J]. MEDS Chin. Med. 20224(1): 040109[2026-01-22]. .
[62]	付佳宁,赵氏淳,郝凌烽,等.金银花-蒲公英提取液纳米相态凝胶剂制备及对大鼠痤疮模型的药效评价[J].中草药,2024,55(24):8416-8424.
	FU J N, ZHAO S C, HAO L F, et al.. Preparation of nano-phase gel from extract of Lonicerae Japonicae Flos-Taraxaci herba and its pharmacodynamic evaluation on rat acne model[J]. Chin. Tradit. Herb. Drugs, 2024, 55(24): 8416-8424.
[63]	WANG Q, GAN Z, WANG X, et al.. Dissolving hyaluronic acid-based microneedles to transdermally deliver eugenol combined with photothermal therapy for acne vulgaris treatment[J]. ACS Appl. Mater. Interfaces, 2024, 16(17): 21595-21609.
[64]	夏明静,曹煜,杨捷,等.22种抗菌消炎中药有效成分对痤疮丙酸杆菌的抑制作用[J].中华皮肤科杂志,2001,34(6):435-436.
	XIA M J, CAO Y, YANG J, et al.. Inhibition of Propionibacterium acnes by effective components of traditional Chinese medicines[J]. Chin. J. Dermatol., 2001, 34(6): 435-436.
[65]	XIONG H, LI X, MOU X, et al.. Syringic acid suppresses Cutibacterium acnes-induced inflammation in human keratinocytes via regulating the NLRP3/caspase-1/IL-1β signaling axis by activating PPARγ/Nrf2-antioxidant pathway[J/OL]. Int. Immunopharmacol., 2024, 139: 112708[2026-01-22]. .

功效	药食同源物质的活性成分	模型	具体功效	参考文献
减缓银屑病等皮肤炎症	甘草醇	莫喹莫特诱导的小鼠银屑病样模型	通过抗炎抑制银屑病样症状，对 HaCaT细胞有抑制作用并调节相关蛋白表达	[8]
	黄芪甲苷	—	抑制角质形成细胞增殖和炎症，改善银屑病样皮肤损伤	[9]
	当归饮子	莫喹莫特诱导的小鼠银屑病样模型；寻常型银屑病患者临床试验	修复银屑病皮肤屏障，改善多项皮肤功能指标并降低复发率	[10-11]
促进创面愈合	甘草酸二钾	大鼠切除伤口模型；成年和老年大鼠伤口模型	调节炎症促进皮肤伤口愈合，涉及多种细胞因子和组织修复过程	[12-13]
	蜂蜜	大鼠皮肤缺损模型	在皮肤修复不同阶段分别促进炎性细胞分泌、消散炎症、促进组织增生和抑制过度增生	[14]
	环黄芪醇	大鼠糖尿病性皮肤溃疡模型	激活Wnt/β-catenin信号通路促进糖尿病性皮肤溃疡愈合	[15]
祛斑和美白	茯苓总三萜	动物实验	捕获黑色素合成中间体多巴醌,抑制酪氨酸酶	[16]
祛斑和美白	甘草黄酮	黄褐斑患者临床试验	抑制黑色素形成，对黄褐斑有较好治疗效果	[17]
缓解光老化	山楂多酚提取物	紫外线诱导的HaCaT细胞模型和小鼠损伤模型	调节相关表达抑制小鼠皮肤光老化，清除ROS等逆转 UVB 照射影响	[18-20]
	菊花花蕾提取物	紫外线照射的HaCaT等细胞模型和小鼠皮肤光老化模型	调节通路缓解UVB诱导的皮肤光老化，改善皮肤状况	[21]
	茯苓水提物	紫外线诱导的小鼠皮肤损伤模型	通过增加肠道丙酸代谢菌群，修复紫外线照射导致的肠道绒毛损伤和黏液减少，从而改善皮肤的光损伤	[22]
	枸杞多糖组分	紫外线诱导的小鼠皮肤损伤模型	抗表皮增厚和低胶原密度	[23]
抗皮肤衰老	白芷醇提物	D-半乳糖诱导的小鼠亚急性衰老模型	具有抗氧化活性与延缓皮肤衰老相关	[24]
	茯苓提取物	D-半乳糖诱导的衰老大鼠皮肤老化模型	改善皮肤老化，促进胶原积累和透明质酸生成；减轻氧化应激相关的皮肤老化	[25-26]
	葛根	自然衰老小鼠模型	提高总抗氧化能力和羟自由基抑制率，延缓皮肤组织的衰老	[27-28]
	枸杞多糖	D-半乳糖诱导的衰老小鼠皮肤老化模型	提高皮肤含水量、成纤维细胞数及表皮和真皮厚度，延缓衰老	[29]
缓解痤疮	当归芍药散活性成分	油酸+痤疮丙酸杆菌诱导的大鼠耳廓痤疮模型	调控JNK/p38 MAPK信号通路，改善痤疮	[30]
缓解痤疮	茯苓丸合当归须散活性成分	痤疮患者临床试验	青春期后痤疮患者皮损、皮肤油脂增多	[31]

功效	药食同源物质的活性成分	模型	具体功效	参考文献
减缓银屑病等皮肤炎症	甘草醇	莫喹莫特诱导的小鼠银屑病样模型	通过抗炎抑制银屑病样症状，对 HaCaT细胞有抑制作用并调节相关蛋白表达	[8]
	黄芪甲苷	—	抑制角质形成细胞增殖和炎症，改善银屑病样皮肤损伤	[9]
	当归饮子	莫喹莫特诱导的小鼠银屑病样模型；寻常型银屑病患者临床试验	修复银屑病皮肤屏障，改善多项皮肤功能指标并降低复发率	[10-11]
促进创面愈合	甘草酸二钾	大鼠切除伤口模型；成年和老年大鼠伤口模型	调节炎症促进皮肤伤口愈合，涉及多种细胞因子和组织修复过程	[12-13]
	蜂蜜	大鼠皮肤缺损模型	在皮肤修复不同阶段分别促进炎性细胞分泌、消散炎症、促进组织增生和抑制过度增生	[14]
	环黄芪醇	大鼠糖尿病性皮肤溃疡模型	激活Wnt/β-catenin信号通路促进糖尿病性皮肤溃疡愈合	[15]
祛斑和美白	茯苓总三萜	动物实验	捕获黑色素合成中间体多巴醌,抑制酪氨酸酶	[16]
祛斑和美白	甘草黄酮	黄褐斑患者临床试验	抑制黑色素形成，对黄褐斑有较好治疗效果	[17]
缓解光老化	山楂多酚提取物	紫外线诱导的HaCaT细胞模型和小鼠损伤模型	调节相关表达抑制小鼠皮肤光老化，清除ROS等逆转 UVB 照射影响	[18-20]
	菊花花蕾提取物	紫外线照射的HaCaT等细胞模型和小鼠皮肤光老化模型	调节通路缓解UVB诱导的皮肤光老化，改善皮肤状况	[21]
	茯苓水提物	紫外线诱导的小鼠皮肤损伤模型	通过增加肠道丙酸代谢菌群，修复紫外线照射导致的肠道绒毛损伤和黏液减少，从而改善皮肤的光损伤	[22]
	枸杞多糖组分	紫外线诱导的小鼠皮肤损伤模型	抗表皮增厚和低胶原密度	[23]
抗皮肤衰老	白芷醇提物	D-半乳糖诱导的小鼠亚急性衰老模型	具有抗氧化活性与延缓皮肤衰老相关	[24]
	茯苓提取物	D-半乳糖诱导的衰老大鼠皮肤老化模型	改善皮肤老化，促进胶原积累和透明质酸生成；减轻氧化应激相关的皮肤老化	[25-26]
	葛根	自然衰老小鼠模型	提高总抗氧化能力和羟自由基抑制率，延缓皮肤组织的衰老	[27-28]
	枸杞多糖	D-半乳糖诱导的衰老小鼠皮肤老化模型	提高皮肤含水量、成纤维细胞数及表皮和真皮厚度，延缓衰老	[29]
缓解痤疮	当归芍药散活性成分	油酸+痤疮丙酸杆菌诱导的大鼠耳廓痤疮模型	调控JNK/p38 MAPK信号通路，改善痤疮	[30]
缓解痤疮	茯苓丸合当归须散活性成分	痤疮患者临床试验	青春期后痤疮患者皮损、皮肤油脂增多	[31]

药食同源物质对皮肤健康影响的研究进展

Research Progress on Effects of Medicinal and Food Homologous Substances on Skin Health

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[1]	刘星宇, 赵国利, 李雪婧. 氢气在医学领域的应用进展[J]. 生物技术进展, 2024, 14(1): 102-110.
[2]	张维, 王红芳, 胥保华. 生物衰老的主要分子机制概述[J]. 生物技术进展, 2023, 13(2): 228-233.