Abstract: The mechanism of inflammation transforming into cancer has always been the focus of cancer research. As the environment in which inflammation-tumor transformation starts, inflammatory microenvironment is a large collection of various regulatory factors and cells, including tumor stem cells, tumor-related macrophages and cytokines (such as chemokines and growth factors) that play crucial roles in the process of tumor initiation, occurrence, evolution and even malignant transformation and metastasis in common ocular tumors. Based on this, the effects of tumor-related cells, cytokines and extracellular matrix in inflammatory microenvironment on the proliferation, metastasis, infiltration and invasion of tumor cells were mainly discussed, with emphasis on the molecular mechanism related to ocular inflammation-tumor transformation. The characteristics of common ocular tumors, such as retinoblastoma and adenoid cystic carcinoma, and the molecules that play  important regulatory roles in the process from inflammation to tumorigenesis were also reviewed. Finally, the future diagnosis and treatment methods were prospected for the ubiquitous signal pathways and molecular targets of these ocular tumors, so as to design ideas for the mentioned inflammatory components in the future diagnosis and treatment of ophthalmic tumors, and to maximize the prevention of inflammation-tumor transformation and malignant transformation.

Key words: inflammation, tumor microenvironment, ocular tumor, malignant transformation

摘要： 炎症向癌症转化的机制一直是癌症研究中的重点。作为炎症-肿瘤转化起始时所处的环境，炎性微环境是一个多种调控因子、细胞的大集合，其中包含的肿瘤干细胞、肿瘤相关巨噬细胞以及细胞因子（如趋化因子、生长因子）等在常见的眼部肿瘤中对肿瘤的起始、发生、演进乃至恶性转化和转移的过程起到了至关重要的调控作用。基于此，主要讨论了在炎性微环境中的肿瘤相关细胞、细胞因子以及细胞外基质等对肿瘤细胞的增殖、转移、浸润、侵袭过程的影响，着重探讨了眼部炎症-肿瘤转化相关的分子机制；并综述了视网膜母细胞瘤、腺样囊性癌等常见眼部肿瘤的特征及其由炎症到肿瘤发生过程中起重要调控作用的分子；最后，针对这些眼部肿瘤普遍存在的信号通路和分子靶点做出了对未来诊断及治疗方法的展望，以期在今后对眼科肿瘤的诊治过程中，能够针对提及的炎性成分设计思路，最大化防止炎症-肿瘤转化和恶性转归出现。

关键词: 炎症, 炎性微环境, 眼部肿瘤, 恶性转化