Research Progress on Hippo Signaling Pathway in Cancer Stem Cell

doi:10.19586/j.2095-2341.2023.0149

Current Biotechnology ›› 2024, Vol. 14 ›› Issue (2): 211-220.DOI: 10.19586/j.2095-2341.2023.0149

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Research Progress on Hippo Signaling Pathway in Cancer Stem Cell

Weijian ZHAO(), Hongting XU, Xiangqian XIAO(), Wang SHENG()

Faculty of Environment and Life，Beijing University of Technology，Beijing 100124，China

Received:2023-11-21 Accepted:2024-01-02 Online:2024-03-25 Published:2024-04-17
Contact: Xiangqian XIAO,Wang SHENG

肿瘤干细胞中的Hippo信号通路研究进展

赵维坚(), 徐弘庭, 肖向茜(), 盛望()

北京工业大学环境与生命学部，北京 100124

通讯作者: 肖向茜,盛望
作者简介:赵维坚 E-mail: zhaowj@emails.bjut.edu.cn
基金资助:
国家自然科学基金项目(31770999)

Abstract

Abstract:

In recent years， how to inhibit the proliferation of tumor cells and the expression of stem genes has become one of the focuses of scientists in cancer treatment. Cancer stem cell （CSC） is a kind of cell group with self-renewal ability in tumors， and is considered as one of the driving factors in the process of tumorigenesis. The Hippo signaling pathway is a highly conserved signaling pathway in biological evolution that plays an important role in cell proliferation， tissue development， and organ size. In this article， Hippo signaling pathway and its mechanism in cancer stem cell were briefly reviewed， and the prospect of tumor treatment was proposed， in order to provide reference for the development and future treatment of tumor stem cells.

Key words: Hippo signaling pathway, cancer stem cell, targeted therapy

摘要：

如何抑制肿瘤细胞的增殖和干性基因的表达已经成为近年来科学家在癌症治疗领域关注的重点之一。肿瘤干细胞(cancer stem cell，CSC)是肿瘤中一类具有自我更新能力的细胞类群，被认为是肿瘤发生过程中的驱动因素之一。Hippo信号通路在生物进化过程中高度保守，且对细胞增殖、组织发育和器官大小具有重要作用。简述了Hippo信号通路及其在肿瘤干细胞中的作用机制，并对肿瘤的治疗提出了展望，以期为肿瘤干细胞的发展和未来治疗提供参考。

关键词: Hippo信号通路, 肿瘤干细胞, 靶向治疗

CLC Number:

Q291

Weijian ZHAO, Hongting XU, Xiangqian XIAO, Wang SHENG. Research Progress on Hippo Signaling Pathway in Cancer Stem Cell[J]. Current Biotechnology, 2024, 14(2): 211-220.

赵维坚, 徐弘庭, 肖向茜, 盛望. 肿瘤干细胞中的Hippo信号通路研究进展[J]. 生物技术进展, 2024, 14(2): 211-220.

Figures/Tables 4

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压力形式	对Hippo通路的影响	参考文献
缺氧应激	降低YAP磷酸化水平，促进YAP核定位	[46, 48]
氧化应激	促进YAP核定位	[47, 49-51]
热应激	诱导YAP去磷酸化和活化	[44, 52]
缺血性损伤	增加YAP的表达对组织缺血再灌注保护的反应	[45, 53]
高渗胁迫	诱导TAZ的酪氨酸磷酸化，TEAD细胞质定位	[54-55]

压力形式	对Hippo通路的影响	参考文献
缺氧应激	降低YAP磷酸化水平，促进YAP核定位	[46, 48]
氧化应激	促进YAP核定位	[47, 49-51]
热应激	诱导YAP去磷酸化和活化	[44, 52]
缺血性损伤	增加YAP的表达对组织缺血再灌注保护的反应	[45, 53]
高渗胁迫	诱导TAZ的酪氨酸磷酸化，TEAD细胞质定位	[54-55]

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Research Progress on Hippo Signaling Pathway in Cancer Stem Cell

肿瘤干细胞中的Hippo信号通路研究进展

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