Research Progress of Mitochondrial Biosynthesis in Diabetes Cardiomyopathy

doi:10.19586/j.2095-2341.2023.0128

Current Biotechnology ›› 2024, Vol. 14 ›› Issue (2): 221-227.DOI: 10.19586/j.2095-2341.2023.0128

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Research Progress of Mitochondrial Biosynthesis in Diabetes Cardiomyopathy

Yuqi WANG¹(), Xinyu WANG¹, Yingfan WANG², Yuancui MENG², Xizhang YAN¹, Pan CHANG³()

^1.Department of Anesthesiology，Second Clinical Medical College，Xi'an Medical College，Xi'an 710038，China
^2.Department of Neonatology，Second Affiliated Hospital of Xi'an Medical College，Xi'an 710038，China
^3.Department of Cardiology，Second Affiliated Hospital of Xi'an Medical College，Xi'an 710038，China

Received:2023-10-17 Accepted:2023-12-12 Online:2024-03-25 Published:2024-04-17
Contact: Pan CHANG

线粒体生物合成在糖尿病心肌病中的研究进展

王钰淇¹(), 王心雨¹, 王颖凡², 孟远翠², 严喜章¹, 常盼³()

^1.西安医学院第二临床医学院麻醉系，西安 710038
^2.西安医学院第二附属医院新生儿科，西安 710038
^3.西安医学院第二附属医院心内科，西安 710038

通讯作者: 常盼
作者简介:王钰淇 E-mail: wyq01252021@163.com；
基金资助:
国家自然科学基金项目(82300407);陕西省科技厅自然基础重点项目(2023-JC-ZD-55);西安医学院大学生创新创业训练计划项目(S202311840063);陕西省教育厅产业化项目(23JC059)

Abstract

Abstract:

Diabetic cardiomyopathy （DCM） is one of the most serious and common complications of diabetesmellitus （DM）， and its pathogenesis is not well understood. A growing body of studies has shown that mitochondrial homeostasis is closely related to the development of DCM. Mitochondrial biosynthesis， as an important part of mitochondrial homeostasis， is involved in the occurrence and development of DCM. Improving mitochondrial function by regulating molecular mechanisms related to mitochondrial biosynthesis may be a new target for the prevention and treatment of DCM. Based on the literature at home and abrod in recent years， the mechanism and research progress of mitochondrial biosynthesis in DCM were summarized in order to provide a reference for the prevention and treatment of DCM.

Key words: diabetic cardiomyopathy, mitochondrial biosynthesis, hypoglycemics, mitochondrial homeostasis

摘要：

糖尿病心肌病（diabetic cardiomyopathy，DCM）是糖尿病（diabetesmellitus，DM)最严重和最常见的并发症之一，其发病机制尚未明确。越来越多的研究表明，线粒体稳态与DCM病程的发展密切相关。线粒体生物合成作为线粒体稳态的重要组成部分，参与DCM的发生发展过程。通过调节线粒体生物合成相关的分子机制以改善线粒体功能，有望做为防治DCM的新靶点。根据近年来国内外文献，总结了线粒体生物合成在DCM中的作用机制和研究进展，以期为DCM的预防和治疗提供参考。

关键词: 糖尿病心肌病, 线粒体生物合成, 降糖药, 线粒体稳态

CLC Number:

Q731

Yuqi WANG, Xinyu WANG, Yingfan WANG, Yuancui MENG, Xizhang YAN, Pan CHANG. Research Progress of Mitochondrial Biosynthesis in Diabetes Cardiomyopathy[J]. Current Biotechnology, 2024, 14(2): 221-227.

王钰淇, 王心雨, 王颖凡, 孟远翠, 严喜章, 常盼. 线粒体生物合成在糖尿病心肌病中的研究进展[J]. 生物技术进展, 2024, 14(2): 221-227.

Figures/Tables 1

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[1]	Min LIAO, Luo YANG, Zhen WANG, Yarong HAO. Protective Effect of Echinacoside on Myocardium in db/db Diabetic Mice [J]. Current Biotechnology, 2022, 12(1): 129-134.
[2]	Min LIAO, Luo YANG, Zhen WANG, Yarong HAO. Research Progress on the Pathogenesis of Diabetic Cardiomyopathy [J]. Current Biotechnology, 2021, 11(6): 700-704.

Research Progress of Mitochondrial Biosynthesis in Diabetes Cardiomyopathy

线粒体生物合成在糖尿病心肌病中的研究进展

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