Abstract:

Chronic respiratory diseases （CRD） are the leading cause of death for over 4 million people each year worldwide. Although current treatments help manage daily symptoms and improve patients' quality of life， the acute exacerbations primarily triggered by respiratory infections still need prevention. Therefore， CRD patients are the main target of vaccination against infectious diseases. In this article， we reviewed the latest technologies available for vaccines specifically indicated for CRD patients， including respiratory syncytial virus vaccines， SARS-CoV-2 vaccines for pneumococcal infections， influenza， pertussis vaccines， and more， which was expected to provide reference for the prevention strategies for chronic respiratory diseases.

Key words: chronic respiratory diseases, influenza, pertussis, pneumococcal disease vaccine, respiratory syncytial virus, SARS-CoV-2

摘要：

慢性呼吸道疾病（chronic respiratory diseases，CRD）是导致全球每年逾400万人死亡的主要原因。尽管现有治疗方法有助于控制CRD患者日常症状并提高生活质量，但预防由呼吸道感染引发的急性加重仍是治疗的关键。因此，CRD患者是感染性疾病疫苗接种的主要对象。针对CRD患者特定疫苗的最新技术，介绍了呼吸道合胞病毒疫苗、严重急性呼吸综合征冠状病毒2型（severe acute respiratory syndrome cornonavius 2，SARS-CoV-2）疫苗、肺炎球菌疫苗、流感疫苗、百日咳疫苗等最新研发进展，以期为慢性呼吸道疾病预防策略提供参考。

关键词: 慢性呼吸道疾病, 流感, 百日咳, 肺炎球菌疾病疫苗, 呼吸道合胞病毒, SARSCoV-2