Research Progress of Hydrogen Molecules in Improving Inflammatory and Osteoporotic Bone Loss Related Diseases

doi:10.19586/j.2095-2341.2024.0057

Current Biotechnology ›› 2024, Vol. 14 ›› Issue (4): 576-585.DOI: 10.19586/j.2095-2341.2024.0057

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Research Progress of Hydrogen Molecules in Improving Inflammatory and Osteoporotic Bone Loss Related Diseases

Shihao JIANG(), Xinyue ZHU, Xiaohu WEN, Ziyi LIU, Pengxiang ZHAO()

College of Chemistry and Life Sciences，Beijing University of Technology，Beijing 100124，China

Received:2024-03-22 Accepted:2024-04-22 Online:2024-07-25 Published:2024-08-07
Contact: Pengxiang ZHAO

氢分子在改善炎性和骨质疏松型骨丢失相关疾病中的研究进展

姜世豪(), 朱昕玥, 文小虎, 刘子怡, 赵鹏翔()

北京工业大学化学与生命科学学院，北京 100124

通讯作者: 赵鹏翔
作者简介:姜世豪 E-mail: wsjsh666@163.com；
基金资助:
军委后勤保障部开放研究重点项目(BHJ17L08)

Abstract

Abstract:

With the increasing aging population worldwide， the number of patients with skeletal system diseases such as bone metabolism and bone loss continues to rise. Despite the continuous deepening of research in the field of bone loss， effective drugs for treating bone loss in clinical practice still need to be developed. Hydrogen has biological properties such as antioxidant， anti-inflammatory， and anti apoptotic properties， and has shown good therapeutic effects in bone loss related diseases in recent years. This article mainly reviewed the pathogenesis of inflammatory， osteoporotic， and severe bone loss， with a focus on the research progress of hydrogen gas in improving bone loss related diseases such as inflammatory and osteoporotic， aiming to provide a theoretical basis and ideas for clinical treatment of bone loss related diseases.

Key words: hydrogen, bone, bone loss

摘要：

随着世界范围内人口老龄化程度的加剧，骨代谢、骨丢失等骨骼系统疾病患者数量持续上升。尽管骨丢失领域的研究在不断深入，目前临床上治疗骨丢失的有效药物仍有待研发。氢气具有抗氧化、抗炎、抗凋亡等生物学特性，近年来在骨丢失相关疾病中展现出良好的治疗效果。综述总结了炎症性、骨质疏松型、失重型等骨丢失的发病机理，重点介绍了氢气在改善炎性和骨质疏松型等骨丢失相关疾病中的研究进展，旨在为临床上治疗骨丢失相关疾病提供理论基础和思路。

关键词: 氢气, 骨, 骨丢失

CLC Number:

R685

Shihao JIANG, Xinyue ZHU, Xiaohu WEN, Ziyi LIU, Pengxiang ZHAO. Research Progress of Hydrogen Molecules in Improving Inflammatory and Osteoporotic Bone Loss Related Diseases[J]. Current Biotechnology, 2024, 14(4): 576-585.

姜世豪, 朱昕玥, 文小虎, 刘子怡, 赵鹏翔. 氢分子在改善炎性和骨质疏松型骨丢失相关疾病中的研究进展[J]. 生物技术进展, 2024, 14(4): 576-585.

Figures/Tables 4

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疾病类型	试验类型	氢分子介入方式	作用机制	参考文献
类风湿关节炎	临床试验	饮用富氢水	氢气可能通过减轻氧化应激缓解疾病症状	[47-48]
	临床试验	注射氢生理盐水	氢气可能通过清除羟基自由基破坏NF-κB信号通路中过量活性氧上调的促炎细胞因子——烟酰胺腺嘌呤二核苷酸磷酸氧化酶-超氧化物和过氧化氢的正反馈循环	[47-48]
	动物实验	注射氢生理盐水	氢气可能通过抑制MAPKs和NF-κB通路的活化和调节TGF-β1表达减缓RA的发展	[49-52]
		饮用富氢水	氢气可能通过减轻氧化应激来保护骨骼免受RA的影响
		吸入氢气	氢气通过减轻大鼠体内氧化应激，减少大鼠关节组织破坏，阻止机械痛敏的形成
		植入储氢材料	氢气通过清除活性氧和炎症，减轻氧化应激并降低炎症细胞因子水平
	细胞实验	过氧化氢和氢气共处理类风湿关节炎细胞	氢气可能通过抑制MAPKs和NF-κB通路的活化和调节TGF-β1表达减缓RA的发展	[49, 51]
	细胞实验	储氢材料共培养	氢气通过清除活性氧和炎症，减轻氧化应激并降低炎症细胞因子水平	[49, 51]
骨性关节炎	动物实验	关节处注射储氢材料	局部输送高浓度氢气可减轻组织炎症并防止软骨被破坏	[54]
		腹腔注射氢水	富氢水可能通过抗氧化和抗炎作用对骨性关节炎起到保护作用	[55]
		腹腔注射氢水	富氢水能够减轻骨性关节炎中软骨的氧化损伤和炎症反应，减少软骨细胞凋亡	[56]
		吸入氢气	氢气通过抑制JNK信号通路的激活，减轻人类软骨细胞的凋亡反应和细胞外基质降解	[3]
	细胞实验	储氢材料处理脂多糖刺激的软骨细胞	局部输送高浓度氢气可减轻组织炎症并防止软骨被破坏	[54]
	细胞实验	氢氧氮混合气培养患者软骨细胞	氢气通过抑制JNK信号通路的激活，减轻人类软骨细胞中的凋亡反应和细胞外基质降解	[3]
银屑病关节炎	临床试验	滴注氢生理盐水	氢气可能通过减少体内自由基缓解银屑病关节炎病变的发展	[57]
		吸入氢气
		饮用富氢水
痛风性关节炎	动物实验	氢生理盐水灌胃	氢气通过清除自由基、改变体液pH、促进尿酸排出和保护血管内皮细胞中一个或多个环节减轻痛风性关节炎进展	[58]
创伤性关节炎	动物实验	注射氢生理盐水	未提及	[59]

疾病类型	试验类型	氢分子介入方式	作用机制	参考文献
类风湿关节炎	临床试验	饮用富氢水	氢气可能通过减轻氧化应激缓解疾病症状	[47-48]
	临床试验	注射氢生理盐水	氢气可能通过清除羟基自由基破坏NF-κB信号通路中过量活性氧上调的促炎细胞因子——烟酰胺腺嘌呤二核苷酸磷酸氧化酶-超氧化物和过氧化氢的正反馈循环	[47-48]
	动物实验	注射氢生理盐水	氢气可能通过抑制MAPKs和NF-κB通路的活化和调节TGF-β1表达减缓RA的发展	[49-52]
		饮用富氢水	氢气可能通过减轻氧化应激来保护骨骼免受RA的影响
		吸入氢气	氢气通过减轻大鼠体内氧化应激，减少大鼠关节组织破坏，阻止机械痛敏的形成
		植入储氢材料	氢气通过清除活性氧和炎症，减轻氧化应激并降低炎症细胞因子水平
	细胞实验	过氧化氢和氢气共处理类风湿关节炎细胞	氢气可能通过抑制MAPKs和NF-κB通路的活化和调节TGF-β1表达减缓RA的发展	[49, 51]
	细胞实验	储氢材料共培养	氢气通过清除活性氧和炎症，减轻氧化应激并降低炎症细胞因子水平	[49, 51]
骨性关节炎	动物实验	关节处注射储氢材料	局部输送高浓度氢气可减轻组织炎症并防止软骨被破坏	[54]
		腹腔注射氢水	富氢水可能通过抗氧化和抗炎作用对骨性关节炎起到保护作用	[55]
		腹腔注射氢水	富氢水能够减轻骨性关节炎中软骨的氧化损伤和炎症反应，减少软骨细胞凋亡	[56]
		吸入氢气	氢气通过抑制JNK信号通路的激活，减轻人类软骨细胞的凋亡反应和细胞外基质降解	[3]
	细胞实验	储氢材料处理脂多糖刺激的软骨细胞	局部输送高浓度氢气可减轻组织炎症并防止软骨被破坏	[54]
	细胞实验	氢氧氮混合气培养患者软骨细胞	氢气通过抑制JNK信号通路的激活，减轻人类软骨细胞中的凋亡反应和细胞外基质降解	[3]
银屑病关节炎	临床试验	滴注氢生理盐水	氢气可能通过减少体内自由基缓解银屑病关节炎病变的发展	[57]
		吸入氢气
		饮用富氢水
痛风性关节炎	动物实验	氢生理盐水灌胃	氢气通过清除自由基、改变体液pH、促进尿酸排出和保护血管内皮细胞中一个或多个环节减轻痛风性关节炎进展	[58]
创伤性关节炎	动物实验	注射氢生理盐水	未提及	[59]

疾病类型	实验类型	氢分子介入方式	作用机制	参考文献
卵巢切除诱导的骨质疏松症	动物实验	吸入氢气	氢气通过抑制NF-kB激活，减少骨质流失，从而具有潜在的抗骨质疏松症作用	[60]
卵巢切除诱导的骨质疏松症	动物实验	饮用富氢水	富氢水通过减轻由雌激素减少引起的氧化应激，预防卵巢切除引起的骨质疏松症	[61]
泼尼松龙诱导的骨质疏松症	动物实验	富氢水饲养斑马鱼	氢分子通过清除泼尼松龙诱导的活性氧并刺激破骨前细胞中的Nrf2，防止破骨细胞活化	[62]
糖尿病诱导的骨质疏松症	动物实验	氢生理盐水灌胃	氢气可能通过改善氧化应激水平，减轻对骨骼的负面影响，保护骨骼健康	[63]
尾悬吊诱导的骨质疏松症	动物实验	吸入氢气	氢分子可能通过减轻氧化应激、恢复成骨细胞分化并抑制破骨细胞分化来改善模拟微重力环境引起的骨丢失	[64]
尾悬吊诱导的骨质疏松症	细胞实验	富氢培养基孵育细胞	氢分子可能通过减轻氧化应激、恢复成骨细胞分化并抑制破骨细胞分化来改善模拟微重力环境引起的骨丢失	[64]

疾病类型	实验类型	氢分子介入方式	作用机制	参考文献
卵巢切除诱导的骨质疏松症	动物实验	吸入氢气	氢气通过抑制NF-kB激活，减少骨质流失，从而具有潜在的抗骨质疏松症作用	[60]
卵巢切除诱导的骨质疏松症	动物实验	饮用富氢水	富氢水通过减轻由雌激素减少引起的氧化应激，预防卵巢切除引起的骨质疏松症	[61]
泼尼松龙诱导的骨质疏松症	动物实验	富氢水饲养斑马鱼	氢分子通过清除泼尼松龙诱导的活性氧并刺激破骨前细胞中的Nrf2，防止破骨细胞活化	[62]
糖尿病诱导的骨质疏松症	动物实验	氢生理盐水灌胃	氢气可能通过改善氧化应激水平，减轻对骨骼的负面影响，保护骨骼健康	[63]
尾悬吊诱导的骨质疏松症	动物实验	吸入氢气	氢分子可能通过减轻氧化应激、恢复成骨细胞分化并抑制破骨细胞分化来改善模拟微重力环境引起的骨丢失	[64]
尾悬吊诱导的骨质疏松症	细胞实验	富氢培养基孵育细胞	氢分子可能通过减轻氧化应激、恢复成骨细胞分化并抑制破骨细胞分化来改善模拟微重力环境引起的骨丢失	[64]

调控类型	实验类型	研究内容	作用机制	参考文献
骨吸收	细胞实验	氢气处理破骨细胞的分化	氢气通过抑制NF-κB激活减少破骨细胞生成	[60]
	动物实验	氢气对小鼠BMMCs破骨细胞生成的调节	未提及	[65]
	动物实验	注射富氢生理盐水对骨髓源干细胞抗老化效应和机制	氢气可能通过ROS/p53/p21信号通路减轻细胞老化，实现抗老化效应	[66]
骨形成	细胞实验	氢分子在MSCs扩增中防止细胞老化的发生	未提及	[67]
		氢气处理TNF-α诱导下新生大鼠颅骨成骨细胞损伤修复	氢气通过减轻氧化应激、保护线粒体功能、抑制炎症以及增强一氧化氮的生物可用性，缓解TNF-α诱导的成骨细胞损伤	[69]
		氢气对脂多糖剌激后牙周膜细胞成骨能力	氢气可能通过保护人牙周膜细胞成骨能力减弱慢性牙周炎骨吸收	[70]
	动物实验	富氢水促进斑马鱼胚胎的骨骼生成	氢分子作为抗氧化剂促进胚胎成骨细胞的活化，从而促进胚胎成骨细胞的形成	[68]

Research Progress of Hydrogen Molecules in Improving Inflammatory and Osteoporotic Bone Loss Related Diseases

氢分子在改善炎性和骨质疏松型骨丢失相关疾病中的研究进展

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