Abstract:

Since the discovery that hydrogen inhalation could effectively protect against cerebral ischemia-reperfusion injury in 2007， the biological effects of hydrogen have been discovered successively. Hydrogen-rich water or hydrogen-rich saline as the main hydrogen intervention method， which has been widely used in preclinical medicine and clinical research and has been proven to have preventive and therapeutic effects on a variety of diseases. In the past， most of the studies on hydrogen-rich water or hydrogen-rich saline were aimed to introduction of its medical effects. This paper introduced the changes of hydrogen concentration in the body after the intervention of hydrogen-rich water or hydrogen-rich saline， their effects on normal physiological functions， and the protective effects on diseases and the impact on gut microbiota. We also focused on the hydrogen concentration of hydrogen-rich water or hydrogen-rich saline， the time point of intervention， the duration of intervention， and the dose of each intervention in different animal experiment， which amied to provide theoretical basis for the basic research of hydrogen molecules.

Key words: hydrogen-rich water, hydrogen-rich saline, animal experiment, medical effects, gut microbiota

摘要：

自2007年发现吸氢可有效保护脑缺血再灌注损伤以来，氢气的生物学作用被陆续发现。富氢水或富氢生理盐水作为主要的氢气干预方式已广泛应用于基础医学和临床研究中，并且已被证实对多种疾病有很好的预防和治疗作用。以往关于富氢水或富氢生理盐水的研究多是针对其医学效应的介绍，通过介绍富氢水或富氢生理盐水干预后体内氢浓度的变化情况、对正常生理功能的影响、对疾病的保护作用以及对肠道菌群的影响，并对不同动物实验中富氢水或富氢生理盐水的氢气浓度、干预介入时间点、干预时长以及每次干预剂量进行阐述，以期为氢分子基础研究提供一定的理论依据。

关键词: 富氢水, 富氢生理盐水, 动物实验, 医学效应, 肠道菌群