Research Progress of Raman Spectroscopy in the Field of Dermatology

doi:10.19586/j.2095-2341.2021.0056

Current Biotechnology ›› 2022, Vol. 12 ›› Issue (1): 44-49.DOI: 10.19586/j.2095-2341.2021.0056

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Research Progress of Raman Spectroscopy in the Field of Dermatology

Boyuan GUO(), Pengxiang ZHAO(), Hui WANG, Zhen WANG, Tingting YAO, Mengyu LIU, Yao Mawulikplimi ADZAVON, Fei XIE

Beijing International Science and Technology Cooperation Base of Antivirus Drug，Basic Medicine Laboratory，Faculty of Environment and Life，Beijing University of Technology，Beijing 100124，China

Received:2021-04-16 Accepted:2021-06-02 Online:2022-01-25 Published:2022-01-26
Contact: Pengxiang ZHAO

拉曼光谱在皮肤领域的研究进展

郭博远(), 赵鹏翔(), 王惠, 王振, 姚婷婷, 刘梦昱, ADZAVON Yao Mawulikplimi, 谢飞

北京工业大学环境与生命学部基础医学研究室，抗病毒药物北京市国际科技合作基地，北京 100124

通讯作者: 赵鹏翔
作者简介:郭博远 E-mail：83578091@qq.com；
基金资助:
国家自然科学基金项目(81602408);军民融合重大课题(BHJ17L018);北京市博士后科研经费资助(Q6005012202003);北京工业大学2018年新人才项目(015000514118003)

Abstract

Abstract:

Raman spectroscopy is a new optical detection technology， which is often used in material identification. In recent years， with the increasing demand for noninvasive detection， Raman spectroscopy has been gradually applied to biological fields such as disease diagnosis and substance identification. This paper reviewed the research progress of Raman spectroscopy in the field of skin and its value in the identification of skin tissue components and the diagnosis of skin diseases， in order to promote the wide application of Raman spectroscopy in the mechanism research and clinical diagnosis of dermatology.

Key words: Raman spectroscopy, skin, disease diagnosis, mechanism research

摘要：

拉曼光谱是一种新型的光学检测技术，常用于材料鉴定。近年来，随着无创检测需求的增加，拉曼光谱逐渐应用于疾病诊断、物质鉴别等生物领域。综述了拉曼光谱在皮肤领域的研究进展，及其对皮肤组织成分鉴别和皮肤疾病诊断的价值，以期推动拉曼光谱广泛应用于皮肤病学的机理研究和临床诊断。

关键词: 拉曼光谱, 皮肤, 疾病诊断, 机理研究

CLC Number:

Q954.539

Boyuan GUO, Pengxiang ZHAO, Hui WANG, Zhen WANG, Tingting YAO, Mengyu LIU, Yao Mawulikplimi ADZAVON, Fei XIE. Research Progress of Raman Spectroscopy in the Field of Dermatology[J]. Current Biotechnology, 2022, 12(1): 44-49.

郭博远, 赵鹏翔, 王惠, 王振, 姚婷婷, 刘梦昱, ADZAVON Yao Mawulikplimi, 谢飞. 拉曼光谱在皮肤领域的研究进展[J]. 生物技术进展, 2022, 12(1): 44-49.

Figures/Tables 2

References 36

1	WANG D, HE P, WANG Z, et al.. Advances in single cell Raman spectroscopy technologies for biological and environmental applications-Science Direct[J]. Curr. Opin. Biotechnol., 2020, 64:218-229.
2	ANTONIO J S, JACENKO O, FERTALA A, et al.. Collagen structure-function mapping informs applications for regenerative medicine[J/OL]. Bioengineering,2021,8(1):3[2021-10-20]. .
3	KNOX S, O'BOYLE N M. Skin lipids in health and disease: a review[J/OL]. Chem. Physics. Lipids, 2021, 236:105055[2021-10-20]. .
4	FU D. Quantitative chemical imaging with multiplex stimulated Raman scattering microscopy[J]. J. Am. Chem. Soc., 2012, 134(8):3623-3626.
5	ZHANG L, CAMBRON T, NIU Y, et al.. Resolving water, proteins, and lipids from in vivo confocal raman spectra of stratum corneum through a chemometric approach[J/OL]. J. Visual. Exp., 2019,doi: 10.3791/60186[2021-10-20]. .
6	YANG S, SEN C, THOMPSON R, et al.. An in vitro Raman study on compositional correlations of lipids and protein with animal tissue hydration[J/OL]. Vibrat. Spectros., 2020, 107:103022[2021-10-20]. .
7	CATANZARO E, BISHAYEE A, FIMOGNARI C. On a beam of light: photoprotective activities of the marine carotenoids astaxanthin and fucoxanthin in suppression of inflammation and cancer[J/OL]. Marine Drugs, 2020, 18(11):544[2021-10-20]. .
8	BALI A, MOKOS M. Do we utilize our knowledge of the skin protective effects of carotenoids enough?[J/OL]. Antioxidants, 2019, 8(8):259[2021-10-20]. .
9	MOROVATI A, ANSARI M A, TUCHIN V V. In vivo detection of human cutaneous beta-carotene using computational optical clearing[J/OL]. J. Biophot., 2020, doi:10.1002/jbio.202000124. .
10	DANCIK Y, KICHOU H, EKLOUH-MOLINIER C, et al.. Freezing weakens the barrier function of reconstructed human epidermis as evidenced by Raman spectroscopy and percutaneous permeation[J/OL]. Pharmaceutics, 2020, doi:10.1002/jbio.202000124[2021-10-20]..
11	TOH D W K, LOH W W, SUTANTO C N, et al.. Skin carotenoids status and plasma carotenoids: Biomarkers of dietary carotenoids, fruits and vegetables for middle-aged and older Singaporean adults[J]. Br. J. Nutr., 2021,126(9):1-28.
12	JUNG B, DARVIN M E, JUNG S, et al.. Kinetics of the carotenoid concentration degradation of smoothies and their influence on the antioxidant status of the human skin in vivo during 8 wks daily consumption[J]. Nutr. Res., 2020, 81:38-46.
13	CHEN W J, TZENG S L, CHENG E H, et al..Correlation of skin carotenoid levels with embryo development and pregnancy result of in vitro fertilization cycles for couples with unexplained infertility[J]. Food Sci. Nutr., 2020,8(7):3353-3361.
14	CARTMEL B, ANDERSON C, IRWIN M L, et al.. Skin carotenoids are inversely associated with adiposity in breast cancer survivors[J]. Nutr. Res., 2020, 79:77-86.
15	HOROWITZ M, KAISER L L, MANZO R D, et al.. Influence of pre-schooler and parent nutrition education on carotenoid levels of Mexican-heritage children[J]. Public Health Nutr., 2020, 23(13):1-9.
16	JONTONY N, HILL E B, TAYLOR C A, et al.. Diet quality, carotenoid status, and body composition in NCAA division I athletes[J]. Am. J. Health Behav., 2020,44(4):432-443.
17	GUNTER N V, TEH S S, YANG M L, et al.. Natural xanthones and skin inflammatory diseases: multitargeting mechanisms of action and potential application[J/OL]. Front. Pharmacol., 2020, 11:594202[2021-12-21]..
18	ZHANG L, CAMBRON T, NIU Y, et al.. MCR approach revealing protein, water, and lipid depth profile in atopic dermatitis patients' stratum corneum via in vivo confocal raman spectroscopy[J]. Analyt. Chem., 2019, 91(4):2784-2790.
19	LANDULFO S, CARLOS A, BENITO B, et al.. Normal-subtracted preprocessing of Raman spectra aiming to discriminate skin actinic keratosis and neoplasias from benign lesions and normal skin tissues [J]. Lasers Med. Sci., 2019, 35(5):1141-1151.
20	HO C J H, YEW Y W, DINISH U S, et al.. Handheld confocal raman spectroscopy (CRS) for objective assessment of skin barrier function and stratification of severity in atopic dermatitis (AD) patients[J]. J. Dermatol. Sci., 2020, 98(1): 20-25.
21	KNIG K, BREUNIG H G, BATISTA A, et al..Translation of two-photon microscopy to the clinic: multimodal multiphoton CARS tomography of in vivo human skin[J].J. Biomed. Optics,2020,25(1): 1-12.
22	LI Q, LI F, QI X, et al.. Pluronic F127 stabilized reduced graphene oxide hydrogel for the treatment of psoriasis: In vitro and in vivo studies[J/OL]. Coll. Surfaces B: Biointerfaces, 2020, 195: 111246[2021-12-21]..
23	TROIANI T, FALCO V D, NAPOLITANO S, et al.. How we treat locoregional melanoma[J/OL]. ESMO Open,2021, 6(3): 100136[2021-12-21]..
24	YAKIMOV B P, SHIRSHIN E A, SCHLEUSENER J, et al.. Melanin distribution from the dermal-epidermal junction to the stratum corneum: non-invasive in vivo assessment by fluorescence and Raman microspectroscopy[J/OL]. Sci. Rep., 2020, 10(1): 14374[2021-12-21]. .
25	ZHANG Y, MOY A J, FENG X, et al.. Assessment of raman spectroscopy for reducing unnecessary biopsies for melanoma screening[J/OL]. Molecules,2020,25(12):2852[2021-12-21]. .
26	KRITO M, ITUM M, EOVI R. Noninvasive imaging techniques for the diagnosis of nonmelanoma skin cancers[J]. Acta Dermatovenerol. Croat., 2020,28(3):157-165.
27	SANTOS P I, VAN D R, CASPERS P J, et al.. Improving clinical diagnosis of early-stage cutaneous melanoma based on Raman spectroscopy[J]. Br. J. Cancer, 2018,119(11):1339-1346.
28	PALOMBO L, IERMAK I, MARIYAMA L, et al.. Optical clearing agent increases effectiveness of photodynamic therapy in a mouse model of cutaneous melanoma: an analysis by Raman microspectroscopy[J]. Biomed. Optics Express, 2020,11(11):6516-6527.
29	ZAILAIE M Z. Epidermal hydrogen peroxide is not increased in lesional and non-lesional skin of vitiligo[J]. Arch. Dermatol. Res., 2016, 309(1):31-42.
30	KOURBAJ G, BIELFELDT S, SEISE M, et al.. Measurement of dermal water content by confocal RAMAN spectroscopy to investigate intrinsic aging and photoaging of human skin in vivo[J]. Skin Res. Technol., 2020,27(3):404-413.
31	YE H, KRUGER U, WANG T, et al.. Burn-related collagen conformational changes in ex vivo porcine skin using Raman spectroscopy[J/OL]. Sci. Rep., 2019, 9(1):19138[2021-12-21]. .
32	YE H, KRUGER U, WANG T, et al.. Raman spectroscopy accurately classifies burn severity in an ex vivo model[J/OL]. Burns,2021,47(4):812-820.
33	TAKAMASA S, TOMOHIRO A, MASATO S, et al.. Enhancement of skin permeation of a hydrophilic drug from acryl-based pressure-sensitive adhesive tape[J]. Pharm. Res.,2021 Feb;38(2):289-299.
34	ZENG L J, SONG W T, HE W H, et al.. Unconventional passive enhancement of transdermal drug delivery: toward a mechanistic understanding of penetration enhancers releasing from acrylic pressure-sensitive adhesive of patches[J/OL]. Pharm. Res., 2020, 37(9):169[2021-12-21]. .
35	LIU Y, LUNTER D J. Tracking heavy-water-incorporated confocal Raman spectroscopy for evaluating the effects of PEGylated emulsifiers on skin barrier[J/OL]. J. Biophot., 2020, 13(12):e202000286[2021-12-21]. .
36	STETTLER H, CROWTHER J M, BRANDT M, et al.. Targeted dry skin treatment using a multifunctional topical moisturizer[J]. Int. J. Cosm. Sci., 2020,43(2):191-200.

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Research Progress of Raman Spectroscopy in the Field of Dermatology

拉曼光谱在皮肤领域的研究进展

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