Abstract: Human epidermal growth factor (hEGF)  is an important autocrine/paracrine factor in human body.  hEGF and its receptor regulate key processes of cell biology, including proliferation, differentiation, migration and survival of cells.  hEGF plays an important role in cell develepmnet, wound healing and organogenesis.  This paper summarizes the hEGF synthesis, secretion, biochemical character, molecular structure, family, receptor, signal pathways, bioactivity, physiological function, applications, and the methods of production.

Key words: human epidermal growth factor (hEGF); , signal pathways, activities, preparation

摘要： 表皮细胞生长因子是人体内一种重要自分泌/旁分泌的生长因子。人表皮细胞生长因子及其受体调控细胞增殖、分化、迁移、生存等与细胞命运密切相关的过程,在细胞发育、伤口愈合、器官发生中发挥重要作用。本文将对人表皮细胞生长因子的合成、分泌、生化特性、分子结构、家族、受体、信号通路、生物学活性、生理功能、应用及制备方法等方面进行综述。

关键词: 人表皮细胞生长因子, 信号通路, 活性, 制备