Abstract:

Drosophila melanogaster is one of the important model organisms in biological research. The hemopoietic process of Drosophila mainly occurs during embryonic and larval stages. The lymph gland is the main hematopoietic organ in larval stage， which composed of medullary zone （MZ）， cortical zone （CZ） and posterior signal center （PSC）. A variety of signaling pathways plays a key role in regulating progenitor homeostasis in lymph glands. The relative steady state of blood cell is very important for the hematopoiesis and normal survival of Drosophila. This paper introduced the formation process of lymph gland and the signal pathway of maintaining lymph gland homeostasis， in order to lay a theoretical foundation for the detailed classification of lymph gland blood cells and the corresponding functional research.

Key words: Drosophila, hematopoiesis, lymph gland, signal pathway

摘要：

黑腹果蝇（Drosophila melanogaster）是生物学研究中重要的模式生物之一。果蝇造血过程主要发生于胚胎和幼虫阶段，淋巴腺作为幼虫阶段的主要造血器官，由髓质区（medullary zone，MZ）、皮质区（cortical zone，CZ）及后端信号中心区（posterior signal center，PSC）组成。淋巴腺在多种信号通路的调控下，能够维持血细胞的增殖和分化相对稳态，这对于果蝇的造血活动和正常生存均具有重要作用。综述了造血器官淋巴腺的形成过程及维持淋巴腺稳态的信号调节通路，以期为淋巴腺血细胞的详细分类和相应的功能研究奠定理论基础。

关键词: 果蝇, 造血器官, 淋巴腺, 信号通路