Abstract: Quorum sensing (QS) is a kind of communication mechanism between individual bacteria, which widely exists in bacteria. Pseudomonas aeruginosa is an opportunistic pathogen of human beings, which has at least three QS systems, namely las, rhl and pqs systems, and there is a cascade regulation relationship among them, which jointly regulate the expression of many virulence genes and the production of virulence factors. In recent years, it has become a new strategy to control the virulence and pathogenicity of P. aeruginosa for the treatment of this pathogen infection by inhibiting its QS systems. Plant essential oil is a natural quorum sensing inhibitors (QSI). Many active compounds of essential oil can inhibit the QS system of P. aeruginosa, and no drug resistance has been found in bacteria. Based on this, the composition and cascade regulation of QS system of P. aeruginosa were carded, the QS inhibition mechanism and inhibitory activity of plant essential oils were briefly introduced, and the research progress in the inhibitory effects of terpenoids, aromatic compounds, aliphatic compounds and sulfur-containing and nitrogen-containing compounds on QS system of P. aeruginosa was emphatically reviewed, in order to provide reference for the related research of finding and screening safe and efficient bacterial QSI from natural compounds, and lay a theoretical foundation for the prevention and control of pathogenic bacteria.

Key words: quorum sensing systems, quorum sensing inhibitors, essential oils, Pseudomonas aeruginosa

摘要： 群体感应（quorum sensing，QS）是细菌个体与个体之间的一种交流机制，广泛存在于细菌中。铜绿假单胞菌是人类的一种条件致病菌，它具有至少3种QS系统，即las、rhl和pqs系统，且各系统之间存在着级联调控关系，它们共同作用调控着该菌众多毒力基因的表达和毒力因子的产生。近年来，通过抑制铜绿假单胞菌的QS系统以控制其毒力和致病力，成为一种新型的铜绿假单胞菌感染防控策略。植物精油是一种天然的群体感应抑制剂（quorum sensing inhibitors, QSI），多种精油活性化合物都能抑制铜绿假单胞菌的QS系统，而且尚未发现细菌对其产生耐药性。基于此，梳理了铜绿假单胞菌QS系统的组成及其级联调控关系，简要介绍了植物精油的QS抑制机制和抑制活性，并重点综述了萜烯类化合物、芳香族化合物、脂肪族化合物、含硫含氮化合物4类精油化合物对铜绿假单胞菌QS系统抑制作用的研究进展，以期为从天然化合物中发现和筛选安全、高效的细菌QSI的相关研究提供参考，并为致病菌的防控奠定理论基础。

关键词: 群体感应系统, 群体感应抑制剂, 植物精油, 铜绿假单胞菌