暴马桑黄的抗肿瘤活性成分及其作用机制研究进展

doi:10.19586/j.2095-2341.2024.0088

生物技术进展 ›› 2024, Vol. 14 ›› Issue (6): 929-936.DOI: 10.19586/j.2095-2341.2024.0088

• 食药用菌生物技术专题 • 上一篇下一篇

暴马桑黄的抗肿瘤活性成分及其作用机制研究进展

孙恺婧¹(), 刘馨泽¹, 金鑫²(), 杨雪³, 王琦⁴, 李玉⁴, 陈长宝¹, 万茜淋¹()

^1.长春中医药大学吉林省人参科学研究院，长春 130117
^2.东北师范大学，分子表观遗传学教育部重点实验室，长春 130024
^3.长春中医药大学附属医院心血管医学与心脏康复中心，长春 130021
^4.吉林农业大学食药用菌教育部工程研究中心，长春 130118

收稿日期:2024-04-23 接受日期:2024-06-03 出版日期:2024-11-25 发布日期:2024-12-27
通讯作者: 金鑫,万茜淋
作者简介:孙恺婧 E-mail: kaijing325@126.com
基金资助:
吉林省科学技术厅吉林省科技发展计划项目(20230508166RC);吉林省教育厅科学技术研究项目(JJKH20241091KJ)

Research Progress on Antitumor Active Constituents and Their Mechanism of Action of Traditional Chinese Medicine Sanghuangporus baumii

Kaijing SUN¹(), Xinze LIU¹, Xin JIN²(), Xue YANG³, Qi WANG⁴, Yu LI⁴, Changbao CHEN¹, Xilin WAN¹()

^1.Jilin Ginseng Academy，Changchun University of Chinese Medicine，Changchun 130117，China
^2.Key Laboratory of Molecular Epigenetics of the Ministry of Education （MOE），Northeast Normal University，Changchun 130024，China
^3.Cardiovascular Medicine and Cardiac Rehabilitation Center，Affiliated Hospital of Changchun University of Chinese Medicine，Changchun 130021，China
^4.Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi，Jilin Agricultural University，Changchun 130118，China

Received:2024-04-23 Accepted:2024-06-03 Online:2024-11-25 Published:2024-12-27
Contact: Xin JIN,Xilin WAN

摘要/Abstract

摘要：

暴马桑黄（Sanghuangporus baumii)作为一类大型药用真菌，不仅是中国传统中备受推崇的名贵中药材，更随着近年来菌类栽培学研究的迅猛发展，已经成为人工种植桑黄的主要菌种。现代研究发现，暴马桑黄中含有的黄酮类、多糖类、多酚类和萜类等多种化学成分，具有抗肿瘤、抗氧化、抗炎、保肝和抗肝硬化等药理活性。系统整理了暴马桑黄中抗肿瘤活性成分的提取与分离方法，总结了暴马桑黄抑制肿瘤细胞的作用机制，以期为暴马桑黄在医药领域的研究与应用提供理论参考。

关键词: 暴马桑黄, 活性成分, 提取分离, 抗肿瘤

Abstract:

Sanghuangporus baumii is a kind of large medicinal fungus， not only a precious traditional Chinese medicinal herb， but also has become the main strain for artificial cultivation of Sanghuang. The modern research has been found that Sanghuang contains various chemical components such as flavonoids， polysaccharides， polyphenols， and terpenes， and has pharmacological activities such as anti-tumor， antioxidant， anti-inflammatory， hepatoprotective， and anti-liver cirrhosis. The article systematically organized the extraction and separation methods of the anti-tumor active components in Sanghuang， and elaborated on the ways to achieve the inhibitory effect of Sanghuang on tumor cell， in order to provide theoretical reference for the research and application of Sanghuang in the field of medicine.

Key words: Sanghuangporus baumii, active ingredient, extraction and isolation, anti-tumor

中图分类号:

R273

孙恺婧, 刘馨泽, 金鑫, 杨雪, 王琦, 李玉, 陈长宝, 万茜淋. 暴马桑黄的抗肿瘤活性成分及其作用机制研究进展[J]. 生物技术进展, 2024, 14(6): 929-936.

Kaijing SUN, Xinze LIU, Xin JIN, Xue YANG, Qi WANG, Yu LI, Changbao CHEN, Xilin WAN. Research Progress on Antitumor Active Constituents and Their Mechanism of Action of Traditional Chinese Medicine Sanghuangporus baumii[J]. Current Biotechnology, 2024, 14(6): 929-936.

图/表 1

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肿瘤类型	细胞系	作用分子	作用机制	参考文献
结肠癌	HCT 116	TP53、STAT3、CASP3、CTNNB1、PARP1、MYC	细胞增殖、早期凋亡、阻滞S期细胞周期	[23]
胃癌	SGC-7901	Cleaved Caspase-3、PARP、Bax、Bcl-2、mTOR、P-ULK1、p62、Beclin-1及LC3-I	细胞增殖、细胞迁移、细胞凋亡、线粒体凋亡	[40]
乳腺癌	MCF-7	Caspase-7	细胞增殖、细胞活性氧释放	[41]
神经胶质瘤	C6	PI3K、Akt p-PI3K、p-Akt、CyclinA、CDK4、Cyt-C、Caspase-3	细胞凋亡、细胞活性氧释放	[42]
黑色素瘤	A375	Caspase-3、PARP	细胞凋亡	[43]
肝癌	SMMC-7721	VEGF、-α(TNF-α)、Mtor、 p-mTOR、AKT、p-AKT、PI3K、p-PI3K	—	[44-45]

肿瘤类型	细胞系	作用分子	作用机制	参考文献
结肠癌	HCT 116	TP53、STAT3、CASP3、CTNNB1、PARP1、MYC	细胞增殖、早期凋亡、阻滞S期细胞周期	[23]
胃癌	SGC-7901	Cleaved Caspase-3、PARP、Bax、Bcl-2、mTOR、P-ULK1、p62、Beclin-1及LC3-I	细胞增殖、细胞迁移、细胞凋亡、线粒体凋亡	[40]
乳腺癌	MCF-7	Caspase-7	细胞增殖、细胞活性氧释放	[41]
神经胶质瘤	C6	PI3K、Akt p-PI3K、p-Akt、CyclinA、CDK4、Cyt-C、Caspase-3	细胞凋亡、细胞活性氧释放	[42]
黑色素瘤	A375	Caspase-3、PARP	细胞凋亡	[43]
肝癌	SMMC-7721	VEGF、-α(TNF-α)、Mtor、 p-mTOR、AKT、p-AKT、PI3K、p-PI3K	—	[44-45]

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暴马桑黄的抗肿瘤活性成分及其作用机制研究进展

Research Progress on Antitumor Active Constituents and Their Mechanism of Action of Traditional Chinese Medicine Sanghuangporus baumii

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