关键词: 硒, 地方病, 细胞凋亡, 信号转导, 氧化应激

Abstract: The main endemic diseases in our country include Kashin-beck disease, Keshan disease, endemic fluorosis and arseniasis. Their etiology and pathogenesis refer to the deficiency, toxicity and imbalance of macroelement and microelement. The selenium (Se) deficiency is the important environmental factor for Kashin-beck disease and Keshan disease, and Se supplement has good effects of prevention and treatment on Kashin-beck disease and Keshan disease. This article summarized the progress on relationship between Se and Kashin-beck disease and Keshan disease, and the action mechanism of Se in Kashin-beck disease, Keshan disease, endemic fluorosis and arseniasis. The paper was aimed to explore the potential biological functions and molecular mechanisms of Se, which was expected to bring benefits to mankind preferably.

Key words: selenium, endemic diseases, cell apotosis, signal transduction, oxidative stress