Nrf2在脊髓损伤后铁死亡的研究进展

doi:10.19586/j.2095-2341.2022.0178

生物技术进展 ›› 2023, Vol. 13 ›› Issue (2): 240-246.DOI: 10.19586/j.2095-2341.2022.0178

Nrf2在脊髓损伤后铁死亡的研究进展

曹静钰¹(), 刘承梅²(), 祁晨旭¹, 杜开颜¹, 陈蒙¹, 侯思伟²

^1.河南中医药大学，郑州 450046
^2.河南中医药大学第一附属医院，郑州 450099

收稿日期:2022-11-03 接受日期:2023-01-06 出版日期:2023-03-25 发布日期:2023-04-07
通讯作者: 刘承梅
作者简介:曹静钰 E-mail: caojingyu97@163.com；
基金资助:
河南省高等学校重点科研项目(22A360011)

Research Progress of Nrf2 in Ferroptosis After Spinal Cord Injury

Jingyu CAO¹(), Chengmei LIU²(), Chenxu QI¹, Kaiyan DU¹, Meng CHEN¹, Siwei HOU²

^1.Henan University of Chinese Medicine，Zhengzhou 450046，China
^2.The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450099，China

Received:2022-11-03 Accepted:2023-01-06 Online:2023-03-25 Published:2023-04-07
Contact: Chengmei LIU

摘要/Abstract

摘要：

铁死亡是脊髓损伤（spinal cord injury，SCI）后神经元细胞损伤的重要病理机制之一，近几年受到国内外广泛关注，但并未取得突破性进展。目前，有研究发现氧化应激在SCI病理生理过程中发挥着重要作用。核因子E2相关因子2(nuclear factor erythroid-2 related factor 2, Nrf2)因具有抗氧化应激作用并参与SCI后神经修复而成为研究热点，但其调控铁死亡发生发展的机制尚不明确。简要介绍了Nrf2的基础结构及其下游靶基因，总结了铁死亡的相关机制并探索了Nrf2在SCI治疗中的潜在作用，以期为进一步研究其与铁死亡在SCI发生发展中的关系和探索SCI治疗的新策略提供思路。

关键词: 脊髓损伤, 铁死亡, 核因子E2相关因子2, 氧化应激

Abstract:

Ferroptosis is one of the important pathological mechanisms of neuronal cell injury after spinal cord injury （SCI）. It has received widespread attention at home and abroad in recent years， but no effective breakthrough has been achieved. In recent years， it has been found that oxidative stress plays an important role in the pathophysiological process. Nuclear factor E2-related factor 2 （Nrf2） has become a hot topic of research because of its anti-oxidative stress effect and involvement in neural repair after SCI， but its mechanism of regulating the development of ferroptosis is still unclear. In this paper， we briefly described the basic structure of Nrf2 and its downstream target genes， introduced the mechanism of ferroptosis and explored the potential role of Nrf2 in SCI treatment， and provided ideas for further study of its relationship with iron death in the development of SCI and explore new strategies for SCI treatment.

Key words: spinal cord injury, ferroptosis, nuclear factor E2-related factor 2, oxidative stress

中图分类号:

R651.2

曹静钰, 刘承梅, 祁晨旭, 杜开颜, 陈蒙, 侯思伟. Nrf2在脊髓损伤后铁死亡的研究进展[J]. 生物技术进展, 2023, 13(2): 240-246.

Jingyu CAO, Chengmei LIU, Chenxu QI, Kaiyan DU, Meng CHEN, Siwei HOU. Research Progress of Nrf2 in Ferroptosis After Spinal Cord Injury[J]. Current Biotechnology, 2023, 13(2): 240-246.

图/表 1

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Nrf2在脊髓损伤后铁死亡的研究进展

Research Progress of Nrf2 in Ferroptosis After Spinal Cord Injury

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