关键词: 胶原, 聚集, 影响因素, 检测技术

Abstract: Collagen is an important structural protein of the organism. Due to the unique biocompatibility, biodegradability, low immunogenicity, hemostatic, promoting cell growth and other biological characteristics, collagen has been widely used in fields including biomedical materials, foods, cosmetics and drugs. The aggregation behavior of collagen is an important factor affecting the quality of collagen products, and it is a scientific and technical problem that needs to be solved urgently in the process of collagen production. In this paper, the research progress of collagen aggregation behavior in recent years was summarized, the aggregation behavior and aggregates of collagen, the influence of aggregates structure on their biological function, the affecting factors and detection techniques of aggregation behavior as well as the applications of collagen aggregates were introduced, which were expected to provide new thought for development of collagen products.

Key words: collagen, aggregation, affecting factors, detection techniques