Research Progress on the Correlation Between Ferroptosis and Kidney Disease

doi:10.19586/j.2095-2341.2021.0133

Current Biotechnology ›› 2022, Vol. 12 ›› Issue (1): 68-74.DOI: 10.19586/j.2095-2341.2021.0133

• Reviews • Previous Articles Next Articles

Research Progress on the Correlation Between Ferroptosis and Kidney Disease

Tong JIN(), Cheng CHEN()

Department of Nephrology，Renmin Hospital of Wuhan University，Wuhan 430060，China

Received:2021-07-14 Accepted:2021-10-08 Online:2022-01-25 Published:2022-01-26
Contact: Cheng CHEN

铁死亡与肾脏疾病相关性的研究进展

金童(), 陈铖()

武汉大学人民医院肾内科，武汉 430060

通讯作者: 陈铖
作者简介:金童 E-mail： 461422117@qq.com；
基金资助:
国家重点研发计划项目(2016YFC1305503)

Abstract

Abstract:

Ferroptosis is a newly discovered form of non?apoptotic cell death in 2012. Its essence is the morphological change of mitochondria and damage of phospholipid peroxidation caused by the accumulation of iron?dependent reactive oxygen species （ROS） and lipid hydroperoxides. Ferroptosis is related to the pathophysiological process of many renal diseases. However， the molecular mechanism of ferroptosis in renal disease injury is still lacking of systematic and in?depth understanding. The regulation mechanism of ferroptosis， research progress and its role in renal related diseases were reviewed， aiming to provide new ideas and targets for the treatment of kidney disease.

Key words: ferroptosis, lipid peroxidation, kidney disease

摘要：

铁死亡（ferroptosis）是2012年新发现的一种非凋亡的细胞死亡形式，其实质是依赖铁离子的活性氧（reactive oxygen species，ROS）和脂质氢过氧化物蓄积导致的线粒体形态改变和细胞膜磷脂过氧化损伤。铁死亡与许多肾脏疾病的病理生理进程密切相关。然而铁死亡参与肾脏疾病损伤的分子生物学机制尚缺乏系统和深入的认识。针对铁死亡的调控机制、研究进展及其在肾脏相关疾病中的作用作一综述，以期为肾脏疾病的治疗提供新思路、新靶点。

关键词: 铁死亡, 脂质过氧化, 肾脏疾病

CLC Number:

R692

Tong JIN, Cheng CHEN. Research Progress on the Correlation Between Ferroptosis and Kidney Disease[J]. Current Biotechnology, 2022, 12(1): 68-74.

金童, 陈铖. 铁死亡与肾脏疾病相关性的研究进展[J]. 生物技术进展, 2022, 12(1): 68-74.

Figures/Tables 1

References 54

1	DOLMA S, LESSNICK S L, HAHN W C, et al.. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells[J]. Cancer Cell, 2003, 3(3): 285-296.
2	DIXON S J, LEMBERG K M, LAMPRECHT M R, et al.. Ferroptosis: an iron-dependent form of nonapoptotic cell death[J]. Cell, 2012, 149(5): 1060-1072.
3	FRIEDMANN A J, SCHNEIDER M, PRONETH B, et al.. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice[J]. Nat. Cell. Biol., 2014, 16(12): 1180-1191.
4	STOCKWELL B R, FRIEDMANN A J, BAYIR H, et al.. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease[J]. Cell, 2017, 171(2): 273-285.
5	YANG W S, KIM K J, GASCHLER M M, et al.. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis[J/OL]. Proc. Natl. Acad. Sci. USA, 2016,113(34): E4966-E4975[2021-10-12]. .
6	CHENG Z, LI Y. What is responsible for the initiating chemistry of iron-mediated lipid peroxidation: an update[J]. Chem. Rev., 2007, 107(3): 748-766.
7	KAGAN V E, MAO G, QU F, et al.. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis[J]. Nat. Chem. Biol., 2017, 13(1): 81-90.
8	DOLL S, PRONETH B, TYURINA Y Y, et al.. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition[J]. Nat. Chem. Biol., 2017,13(1): 91-98.
9	DOLL S, FREITAS F P, Shah R, et al.. FSP1 is a glutathione-independent ferroptosis suppressor[J]. Nature, 2019, 575(7784): 693-698.
10	FENG H, STOCKWELL B R. Unsolved mysteries: How does lipid peroxidation cause ferroptosis? [J/OL]. PLoS Biol., 2018, 16(5): e2006203[2021-10-12]. .
11	DAHER R, MANCEAU H, KARIM Z. Iron metabolism and the role of the iron-regulating hormone hepcidin in health and disease[J/OL]. Presse. Med., 2017, 46(12 Pt 2):e272-e278[2021-10-12]. .
12	CAPELLETTI M M, MANCEAU H, PUY H, et al.. Ferroptosis in liver diseases: an overview[J/OL]. Int. J. Mol. Sci., 2020, 21(14): 4908[2021-10-12]. .
13	SHEN Z, LIU T, Li Y, et al.. Fenton-reaction-acceleratable magnetic nanoparticles for ferroptosis therapy of orthotopic brain tumors[J]. ACS Nano., 2018, 12(11): 11355-11365.
14	GAO W, ZHAO J, GAO Z, et al.. Synergistic interaction of light alcohol administration in the presence of mild iron overload in a mouse model of liver injury: involvement of triosephosphate isomerase nitration and inactivation[J/OL]. PLoS ONE, 2017, 12(1): e170350[2021-10-12]. .
15	HAN C, LIU Y, DAI R, et al.. Ferroptosis and its potential role in human diseases[J/OL]. Front. Pharmacol., 2020, 11: 239[2021-10-12]. .
16	GAMMELLA E, RECALCATI S, RYBINSKA I, et al.. Iron-induced damage in cardiomyopathy: oxidative-dependent and independent mechanisms[J/OL]. Oxid. Med. Cell. Longev., 2015, 2015:230182[2021-10-12]. .
17	LI J, CAO F, YIN H L, et al.. Ferroptosis: past, present and future[J/OL]. Cell. Death. Dis., 2020, 11(2): 88[2021-10-12]. .
18	HIRSCHHORN T, STOCKWELL B R. The development of the concept of ferroptosis[J]. Free. Radic. Biol. Med., 2019,133:130-143.
19	YANG W S, STOCKWELL B R. Ferroptosis: death by lipid peroxidation[J]. Trends. Cell. Biol., 2016,26(3):165-176.
20	GASCHLER M M, ANDIA A A, LIU H, et al.. FINO(2) initiates ferroptosis through GPX4 inactivation and iron oxidation[J]. Nat. Chem. Biol., 2018, 14(5): 507-515.
21	YAGODA N, MVON RECHENBERG, ZAGANJOR E, et al.. RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels[J]. Nature,2007,447(7146):864-868.
22	SUN X, OU Z, XIE M, et al.. HSPB1 as a novel regulator of ferroptotic cancer cell death[J]. Oncogene, 2015, 34(45): 5617-5625.
23	DOLL S, FREITAS F P, SHAH R, et al.. FSP1 is a glutathione-independent ferroptosis suppressor[J]. Nature,2019,575(7784): 693-698.
24	HOU W, XIE Y, SONG X, et al.. Autophagy promotes ferroptosis by degradation of ferritin[J]. Autophagy, 2016, 12(8): 1425-1428.
25	CHEN G Q, BENTHANI F A, WU J, et al.. Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis[J]. Cell Death. Differ., 2020, 27(1): 242-254.
26	YANG M, CHEN P, LIU J, et al.. Clockophagy is a novel selective autophagy process favoring ferroptosis[J/OL]. Sci. Adv., 2019, 5(7): eaaw2238[2021-10-12]. .
27	DIXON S J, PATEL D N, WELSCH M, et al.. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis[J/OL]. Elife, 2014, 3: e2523[2021-10-12]. .
28	CHEN D, FAN Z, RAUH M, et al.. ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner[J]. Oncogene, 2017, 36(40): 5593-5608.
29	SUN Y, CHEN P, ZHAI B, et al.. The emerging role of ferroptosis in inflammation[J/OL]. Biomed. Pharmacother., 2020, 127: 110108[2021-10-12]. .
30	LINKERMANN A, SKOUTA R, HIMMERKUS N, et al.. Synchronized renal tubular cell death involves ferroptosis[J]. Proc. Natl. Acad. Sci. USA, 2014,111(47):16836-16841.
31	KANG R, ZENG L, ZHU S, et al.. Lipid peroxidation drives gasdermin d-mediated pyroptosis in lethal polymicrobial sepsis[J]. Cell Host. Microbe., 2018, 24(1): 97-108.
32	QI J, KIM J W, ZHOU Z, et al.. Ferroptosis affects the progression of nonalcoholic steatohepatitis via the modulation of lipid peroxidation-mediated cell death in mice[J]. Am. J. Pathol., 2020, 190(1):68-81.
33	LEVEY A S, JAMES M T. Acute kidney injury[J]. Ann. Intern. Med., 2017, 167(9):C66-C80.
34	HU Z, ZHANG H, YANG S K, et al.. Emerging role of ferroptosis in acute kidney injury[J/OL]. Oxid. Med. Cell. Longev., 2019, 2019: 8010614[2021-10-12]. .
35	TONNUS W, LINKERMANN A. The in vivo evidence for regulated necrosis[J]. Immunol. Rev., 2017, 277(1): 128-149.
36	SWAMINATHAN S. Iron homeostasis pathways as therapeutic targets in acute kidney injury[J]. Nephron, 2018, 140(2): 156-159.
37	FRIEDMANN A J, SCHNEIDER M, Proneth B, et al.. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice[J]. Nat. Cell. Biol., 2014, 16(12): 1180-1191.
38	LINKERMANN A, SKOUTA R, HIMMERKUS N, et al.. Synchronized renal tubular cell death involves ferroptosis[J]. Proc. Natl. Acad. Sci. USA, 2014,111(47):16836-16841.
39	ZARJOU A, BOLISETTY S, JOSEPH R, et al.. Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury[J]. J. Clin. Invest., 2013, 123(10): 4423-4434.
40	MARTIN-SANCHEZ D, RUIZ-ANDRES O, POVEDA J, et al.. Ferroptosis, but not necroptosis, is important in nephrotoxic folic acid-induced AKI[J]. J. Am. Soc. Nephrol., 2017, 28(1): 218-229.
41	WANG Y, QUAN F, CAO Q, et al.. Quercetin alleviates acute kidney injury by inhibiting ferroptosis[J]. J. Adv. Res., 2021, 28: 231-243.
42	WEBSTER A C, NAGLER E V, MORTON R L, et al.. Chronic kidney disease[J]. Lancet, 2017, 389(10075): 1238-1252.
43	MENG X M, NIKOLIC-PATERSON D J, LAN H Y. Inflammatory processes in renal fibrosis[J]. Nat. Rev. Nephrol., 2014, 10(9): 493-503.
44	WEN Q, LIU J, KANG R, et al.. The release and activity of HMGB1 in ferroptosis[J]. Biochem. Biophys. Res. Commun., 2019, 510(2): 278-283.
45	YANG L, GUO J, YU N, et al.. Tocilizumab mimotope alleviates kidney injury and fibrosis by inhibiting IL-6 signaling and ferroptosis in UUO model[J/OL]. Life Sci., 2020, 261:118487[2021-10-12]. .
46	LI S, ZHENG L, ZHANG J, et al.. Inhibition of ferroptosis by up-regulating Nrf2 delayed the progression of diabetic nephropathy[J]. Free. Radic. Biol. Med., 2021, 162: 435-449.
47	DE ZEEUW D, AKIZAWA T, AUDHYA P, et al.. Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease[J]. N. Engl. J. Med., 2013, 369(26): 2492-2503.
48	A-EDECLEVES, ZOLKIPLI Z, SATRIANO J, et al.. Regulation of lipid accumulation by AMK-activated kinase in high fat diet-induced kidney injury[J]. Kidney Int., 2014, 85: 611-623.
49	LI C, DONG X, DU W, et al.. LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis[J/OL]. Signal. Transduct. Target. Ther., 2020, 5(1): 187[2021-10-12]. .
50	LEE H, ZANDKARIMI F, ZHANG Y, et al.. Energy-stress-mediated AMPK activation inhibits ferroptosis[J]. Nat. Cell. Biol., 2020, 22(2): 225-234.
51	Singer E A, Gupta G N, MARCHALIK D, et al.. Evolving therapeutic targets in renal cell carcinoma[J]. Curr. Opin. Oncol., 2013,25(3):273-280.
52	YANG W S, SRIRAMARATNAM R, WELSCH M E, et al.. Regulation of ferroptotic cancer cell death by GPX4[J]. Cell, 2014, 156(1-2): 317-331.
53	MAJMUNDAR A J, WONG W J, SIMON M C. Hypoxia-inducible factors and the response to hypoxic stress[J]. Mol. Cell., 2010, 40(2): 294-309.
54	MIESS H, DANKWORTH B, GOUW A M, et al.. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma[J]. Oncogene, 2018, 37(40): 5435-5450.

[1]	Yiwei ZHAO, Tianlu GAO, Jiahui ZHANG, Yuqi WANG, Pan CHANG, Hong WANG. Research Progress on the Imbalance of Mitochondrial Quality Control Leading to Renal Interstitial Fibrosis in Diabetic Kidney Disease [J]. Current Biotechnology, 2024, 14(5): 825-831.
[2]	Mingjiao ZHANG, Jiefu ZHU, Xiongfei WU. Cell Death in Cisplatin-induced Kidney Injury [J]. Current Biotechnology, 2023, 13(5): 718-724.
[3]	Zhen WANG, Kerang HUANG, Lei CHEN, Min ZHOU, Yuanxia XUE. Effect of Erastin on the Ultrastructure of Granular Cells by High Pressure Freezing-freezing Substitution Technology [J]. Current Biotechnology, 2023, 13(4): 637-644.
[4]	Yanrong WANG, Yuanbiao GUO. Construction of a Prognostic Signature for Hepatocellular Carcinoma Based on Ferroptosis-related LncRNAs [J]. Current Biotechnology, 2023, 13(3): 473-481.
[5]	Jingyu CAO, Chengmei LIU, Chenxu QI, Kaiyan DU, Meng CHEN, Siwei HOU. Research Progress of Nrf2 in Ferroptosis After Spinal Cord Injury [J]. Current Biotechnology, 2023, 13(2): 240-246.
[6]	Kaiyan DU, Chenxu QI, Jingyu CAO, Meng CHEN, Jing GAO, Chengmei LIU. Research Progress on the Regulatory Mechanism of Ferroptosis in Spinal Cord Injury [J]. Current Biotechnology, 2022, 12(6): 869-874.

Research Progress on the Correlation Between Ferroptosis and Kidney Disease

铁死亡与肾脏疾病相关性的研究进展

RichHTML

PDF

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 1

References 54

Related Articles 6

Recommended Articles

Metrics

Comments