Abstract: Marine oligosaccharides are prepared by the degradation from marine polysaccharides with mild acids, glycosides and other methods. They have the characteristics of abundant sources, novel structure, small molecular weight and diverse types. They exhibit a variety of biological activities, such as anti-tumor, anti-oxidant, immunomodulatory, and anti-viral activities, etc. Therefore, they are widely used in food, medicine, health products and cosmetics, and have great development potential. In order to timely understand the research progress, promote the application and development of marine oligosaccharides. The research progress of marine oligosaccharides and their derivatives biological activities, such as immunomodulatory, anti-tumor, anti-bacterial, anti-viral, anti-oxidant, anti-radiation, anti-coagulant, anti-diabetes and regulation of the gut microbiota, were summarized, which was expected to provide references for the further research and development of marine oligosaccharides.

Key words: marine oligosaccharides, derivatives, activity

摘要： 海洋寡糖由海洋多糖经弱酸或糖苷酶等方法降解制备，具有来源丰富、结构新颖、分子量小、类型多样等特点，表现出抗肿瘤、抗氧化、免疫调节、抗病毒等多种生物活性，在食品、医药、保健品及化妆品等领域有着广泛的应用，具有巨大的开发潜力。为了及时了解海洋寡糖的研究进展，促进海洋寡糖的应用与开发，就海洋寡糖及其衍生物的免疫调节、抗肿瘤、抑菌、抗病毒、抗氧化、抗辐射、抗凝血、抗糖尿病以及调节肠道微生物等方面的活性研究进展进行了简要总结，以期为海洋寡糖及其衍生物的深入研究和深度开发提供参考。

关键词: 海洋寡糖, 衍生物, 活性