Progress in the Application of Deuterium and its Labeled Compounds in Biomedical Research

doi:10.19586/j.2095-2341.2024.0023

Current Biotechnology ›› 2024, Vol. 14 ›› Issue (5): 785-792.DOI: 10.19586/j.2095-2341.2024.0023

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Progress in the Application of Deuterium and its Labeled Compounds in Biomedical Research

Jinge TANG¹^,²(), Wei REN², Qingqing JIANG², Ning YU¹()

^1.North Sichuan Medical College，Sichuang Nanchong 637000，China
^2.Senior Department of Otolaryngology-head & Neck Surgery，the Sixth Medical Center of PLA General Hospital，Beijing 100853，China

Received:2024-02-20 Accepted:2024-06-04 Online:2024-09-25 Published:2024-10-22
Contact: Ning YU

氘及其标记化合物在生物医药研究中的应用进展

唐金格¹^,²(), 任巍², 蒋晴晴², 于宁¹()

^1.川北医学院，四川南充 637000
^2.解放军总医院第六医学中心耳鼻咽喉头颈外科医学部，北京 100853

通讯作者: 于宁
作者简介:唐金格 E-mail: tangjinge6@163.com；
基金资助:
国家重点研发项目(2020YFC2004001);北京市自然科学基金项目(7222185)

Abstract

Abstract:

Stable isotopes are widely used in fields such as medicine， food safety， and ecological environment due to their characteristics of no radioactivity and good stability. Deuterium is a stable isotope of hydrogen element， and deuterium labeling method has the advantages of simplicity， speed， and low cost. Researches have shown that deuterium isotope labeling has enormous potential for application in the field of life sciences such as metabolic mechanisms， disease prevention and treatment targets， pharmacology， etc. The review summarized the synthesis methods， detection techniques， and applications of deuterium and its compounds in biomedical research， and prospected for the future development， in order to provide reference for researchers and applications in related fields.

Key words: deuterium, isotope, biomedicine, clinical study

摘要：

稳定同位素因具有无放射性、稳定性好等特点，在医药、食品安全、生态环境等领域应用广泛。氘作为氢元素的一种稳定同位素，氘元素标记法具有简单、快捷、价格低等优点。研究发现，氘同位素标记在机体代谢机制、疾病预防及治疗靶点、药理学等生命科学领域具有巨大的应用潜力。综述从氘标记化合物的合成方法、检测技术、氘及其化合物在生物医药研究中的应用等方面进行总结，并对未来发展进行了展望，以期为相关领域的研究与应用提供参考。

关键词: 氘, 同位素, 生物医药, 临床研究

CLC Number:

Q819

Jinge TANG, Wei REN, Qingqing JIANG, Ning YU. Progress in the Application of Deuterium and its Labeled Compounds in Biomedical Research[J]. Current Biotechnology, 2024, 14(5): 785-792.

唐金格, 任巍, 蒋晴晴, 于宁. 氘及其标记化合物在生物医药研究中的应用进展[J]. 生物技术进展, 2024, 14(5): 785-792.

Figures/Tables 8

Fig. 1 H/D exchange under acidic conditions[4]

Fig. 2 Selected iridium (Ⅰ?) catalysts for ortho-directed aromatic HIE[6]

Fig. 3 Manganese-catalyzed trideuteromethylation of ketones[16]

Fig. 4 Tuneable synthesis of acylcarnitines[17]

Fig. 5 Deutetrabenazine[43]

Fig. 6 Structures of CTP-656 (d9-Ivacaftor), d18-Ivacaftor, and Ivacaftor[47]

Fig. 7 The structure of d4IFO

Fig. 8 Structure of CTP-347[51]

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Progress in the Application of Deuterium and its Labeled Compounds in Biomedical Research

氘及其标记化合物在生物医药研究中的应用进展

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