Abstract:

Immunoglobulin Y （IgY）， as a potential therapeutic antibody， is present in many species， from lower amphibians and reptiles to higher animal birds. The development of vaccines has become a competitive arena for global scientists to compete against viruses. Although the vaccine can effectively prevent the infection of the virus， reduce the incidence and mortality of the disease， but the development of the vaccine is time-consuming and costly. IgY has the advantages of easy production， low cost， take effect quickly， and antibody therapy strategies basedon IgY have been widely recognized in recent years. This review focused on the application of IgY in the treatment of viral diseases by reporting the latest research on the characteristics of IgY and the progress of production technology， so as to provide some enlightenment for the application of IgY in the treatment of viral infectious diseases.

Key words: immunoglobulin Y, immunotherapy, viral infectious disease

摘要：

免疫球蛋白Y（immunoglobulin Y, IgY）作为一种潜在的治疗性抗体，存在于许多物种内，从低等的两栖类、爬行类到高等动物鸟类等。疫苗的研发成为全球科学家与病毒“赛跑”的竞争主场。疫苗虽能有效预防病毒的感染，降低疾病的发生率和死亡率，但其开发耗时且成本高昂。IgY具有易生产、成本低、起效快的优点，近年来基于IgY的抗体治疗策略得到广泛认可。概述了IgY特性的最新研究和生产技术的进展，综述了IgY在病毒性疾病治疗方面的应用，从而为IgY在病毒感染性疾病治疗领域的应用提供一些启示。

关键词: IgY, 免疫疗法, 病毒感染性疾病