Application Progress of Hydrogen in Medical Field

doi:10.19586/j.2095-2341.2023.0097

Current Biotechnology ›› 2024, Vol. 14 ›› Issue (1): 102-110.DOI: 10.19586/j.2095-2341.2023.0097

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Application Progress of Hydrogen in Medical Field

Xingyu LIU(), Guoli ZHAO, Xuejing LI

SINOPEC （Dalian） Research Institute of Petroleum and Petrochemical Co. Ltd. ，Liaoning Dalian 116045，China

Received:2023-08-04 Accepted:2023-11-02 Online:2024-01-25 Published:2024-02-05

氢气在医学领域的应用进展

刘星宇(), 赵国利, 李雪婧

中石化（大连）石油化工研究院有限公司，辽宁大连 116045

作者简介:刘星宇 E-mail: liuxingyu.fshy@sinopec.com
基金资助:
国家重点研发项目(2022YFF0705100)

Abstract

Abstract:

Hydrogen has attracted a lot of attention in energy field， at the same time， it is also a clean， efficient and economical technology in medical field. The field of hydrogen medicine mainly includes basic and clinical research on the effects of hydrogen on diseases， such as the usage methods， dosage， health promoting effects， therapeutic effects on diseases， and mechanisms of action of hydrogen. Hydrogen can remove hydroxyl radicals and peroxynitrites，which have significant therapeutic effect for oxidative stress and inflammation related diseases. At the same time， as an endogenous gas， it is non-toxic and harmless， and will not cause adverse reactions to human body. Targeted treatment of brain and nervous system diseases， cardiovascular diseases， diabetes， cancer and other diseases can be achieved through direct intake and controlled release. The article introduced the different ways of releasing hydrogen gas and its applications in the medical field， and looked forward to the scientific and practical issues of hydrogen medicine， in order to provide reference for the application research of hydrogen in the biomedical field.

Key words: hydrogen, nanoparticles, antioxidant, anti-inflammatory

摘要：

氢气在能源领域的优势已日渐凸显，其在医学领域同样是一种清洁、高效、经济的治疗手段。氢医学领域主要包括氢气对疾病的基础研究和临床研究，如氢气的使用方法、剂量、对健康的促进作用、对疾病的治疗效果以及作用机理等。氢分子可以清除羟基自由基和过氧亚硝酸盐，对氧化应激和炎症相关疾病具有显著的治疗效果，同时其作为一种内源性气体，无毒无害，对人体不会造成不良反应。通过直接摄入和控制释放等方式，可以实现对脑和神经系统疾病、心血管疾病、糖尿病和癌症等疾病的靶向治疗。介绍了释放氢气的不同方式及其在医学领域的研究进展，并对氢医学的科学和实践问题进行了展望，以期为氢气在生物医学领域的应用研究提供参考。

关键词: 氢气, 纳米材料, 抗氧化, 抗炎

CLC Number:

Xingyu LIU, Guoli ZHAO, Xuejing LI. Application Progress of Hydrogen in Medical Field[J]. Current Biotechnology, 2024, 14(1): 102-110.

刘星宇, 赵国利, 李雪婧. 氢气在医学领域的应用进展[J]. 生物技术进展, 2024, 14(1): 102-110.

Figures/Tables 7

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释放氢气方式	疾病	研究对象	参考文献
吸入氢气	心脏骤停	5例心脏骤停后昏迷患者	[20]
吸入氢气	心肌梗死	20例ST段提高型心肌梗死患者	[21]
吸入氢气	慢性间歇性缺氧引起的心脏损伤	慢性间歇性缺氧大鼠模型	[22]
吸入氢气	脑梗	50例患者随机对照临床研究	[23]
吸入氢气	胶质母细胞瘤	大鼠原位胶质瘤模型和小鼠皮下异种移植模型	[24]
吸入氢气	晚期癌症（肺癌、胰腺癌、肝癌）	82例Ⅲ期和Ⅳ期癌症患者	[25]
饮用富氢水	肝癌	49例患者随机对照临床研究	[26]
饮用富氢水	帕金森	89例患者随机双盲研究	[27]
饮用富氢水	糖尿病	9例糖尿病患者	[28]
饮用富氢水	2型糖尿病和糖耐量受损	30例2型糖尿病患者和6例糖耐量受损患者	[29]
注射富氢生理盐水	缺血性中风	38例急性缺血性卒中住院患者	[30]
注射富氢生理盐水	心肌缺血再灌注损伤	心脏骤停大鼠模型	[31]
涂覆掺氢二氧化钛纳米棒	糖尿病足溃疡	小鼠糖尿病创面模型	[32]
静脉注射Fe@CMC纳米颗粒	深部肿瘤	肿瘤小鼠模型	[33]
注射氢化钯纳米颗粒	阿尔兹海默症	三倍转基因阿尔茨海默症小鼠模型	[7]
注射载氢微气泡	心肌缺血再灌注损伤	心肌缺血大鼠模型	[34]

释放氢气方式	疾病	研究对象	参考文献
吸入氢气	心脏骤停	5例心脏骤停后昏迷患者	[20]
吸入氢气	心肌梗死	20例ST段提高型心肌梗死患者	[21]
吸入氢气	慢性间歇性缺氧引起的心脏损伤	慢性间歇性缺氧大鼠模型	[22]
吸入氢气	脑梗	50例患者随机对照临床研究	[23]
吸入氢气	胶质母细胞瘤	大鼠原位胶质瘤模型和小鼠皮下异种移植模型	[24]
吸入氢气	晚期癌症（肺癌、胰腺癌、肝癌）	82例Ⅲ期和Ⅳ期癌症患者	[25]
饮用富氢水	肝癌	49例患者随机对照临床研究	[26]
饮用富氢水	帕金森	89例患者随机双盲研究	[27]
饮用富氢水	糖尿病	9例糖尿病患者	[28]
饮用富氢水	2型糖尿病和糖耐量受损	30例2型糖尿病患者和6例糖耐量受损患者	[29]
注射富氢生理盐水	缺血性中风	38例急性缺血性卒中住院患者	[30]
注射富氢生理盐水	心肌缺血再灌注损伤	心脏骤停大鼠模型	[31]
涂覆掺氢二氧化钛纳米棒	糖尿病足溃疡	小鼠糖尿病创面模型	[32]
静脉注射Fe@CMC纳米颗粒	深部肿瘤	肿瘤小鼠模型	[33]
注射氢化钯纳米颗粒	阿尔兹海默症	三倍转基因阿尔茨海默症小鼠模型	[7]
注射载氢微气泡	心肌缺血再灌注损伤	心肌缺血大鼠模型	[34]

释放氢气方式	疾病	研究对象	参考文献
吸入氢气	缺血性脑卒中	心脏骤停大鼠模型	[60]
吸入氢气	缺血性脑卒中	50例患者随机对照临床研究	[23]
饮用富氢水	帕金森	89例患者随机双盲研究	[27]
饮用富氢水	阿尔兹海默症	三倍转基因阿尔茨海默症小鼠模型	[61]
注射富氢溶液	缺血性中风	38例急性缺血性中风患者	[30]
注射氢化钯纳米颗粒	阿尔兹海默症	三倍转基因阿尔茨海默症小鼠模型	[7]

释放氢气方式	疾病	研究对象	参考文献
吸入氢气	缺血性脑卒中	心脏骤停大鼠模型	[60]
吸入氢气	缺血性脑卒中	50例患者随机对照临床研究	[23]
饮用富氢水	帕金森	89例患者随机双盲研究	[27]
饮用富氢水	阿尔兹海默症	三倍转基因阿尔茨海默症小鼠模型	[61]
注射富氢溶液	缺血性中风	38例急性缺血性中风患者	[30]
注射氢化钯纳米颗粒	阿尔兹海默症	三倍转基因阿尔茨海默症小鼠模型	[7]

释放氢气方式	疾病	研究对象	参考文献
吸入氢气	心脏骤停	5例心脏骤停后昏迷患者	[20]
吸入氢气	心肌梗死	20例ST段提高型心肌梗死患者	[21]
吸入氢气	心肌梗死	急性心肌梗死大鼠模型	[64]
吸入氢气	慢性间歇性缺氧引起的心脏损伤	慢性间歇性缺氧大鼠模型	[22]
注射富氢生理盐水	心脏骤停引起的缺血再灌注损伤	心脏骤停大鼠模型	[31]
注射载氢微气泡	心肌缺血再灌注损伤	心肌缺血大鼠模型	[34]

Application Progress of Hydrogen in Medical Field

氢气在医学领域的应用进展

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[2]	HanXiao MA. Development of qPCR Standard Curves for Monitoring Population Dynamics in a Dual-bacterial Fermentative Hydrogen Production System [J]. Current Biotechnology, 2025, 15(2): 325-332.
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[5]	Jiaqi SUN, Jia GUO, Chuang ZHANG, Qing LIU, Ziyu WANG, Hanchao XIA, Buxuan QIAN, Fangfang ZHAO, Qi WANG, Jianfeng LIU, Xiangguo LIU. Research Progress of Phosphite Dehydrogenase in Genetically Engineered Microorganisms and Plants [J]. Current Biotechnology, 2024, 14(2): 173-181.
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