Abstract: In this paper, we introduced biological morphological change during development of normal embryos and cloned embryos, elaborated the difference from the morphological and molecular mechanism between the two, and summed up the main factors which impact the development of reconstruction of nuclear transfer embryos. Moreover, we disscussed morphology in the cells focused on chromosome structural changes to the effect of egg reprogramming, at the molecular level the replacement between the egg histone and the cell histone, in theory, to provide a reference to improve the efficiency of nuclear transfer.

Key words: normal embryos, cloned embryos, chromosome structural changes, histone replacement

摘要： 本文介绍了正常胚胎和核移植重构胚发育过程中的生物学变化,从细胞形态学和分子机理两方面阐述了二者之间的差异,总结了影响核移植重构胚胎发育的主要因素。在细胞形态学上着重探讨了卵子染色体结构变化对于卵重编程作用的影响,在分子水平上对卵子组蛋白与供核细胞组蛋白的置换进行了讨论,理论上为核移植效率的提高提供了借鉴。

关键词: 正常胚胎, 核移植胚胎, 染色体结构变化, 组蛋白置换