Research Progress in Macrocyclic Compounds of Secondary Metabolites from Myxobacteria

doi:10.3969/j.issn.2095-2341.2012.04.05

Current Biotechnology ›› 2012, Vol. 2 ›› Issue (4): 263-269.DOI: 10.3969/j.issn.2095-2341.2012.04.05

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Research Progress in Macrocyclic Compounds of Secondary Metabolites from Myxobacteria

HUANG Yan, HU Jian-wei, ZHU Hong-hui

1.Guangdong Institute of Microbiology; State Key Laboratory of Applied Microbiology, MinistryGuangdong Province Jointly South China Breeding Base; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application; Guangdong Open Laboratory of Applied Microbidogy, Guangzhou 510070, China;

2.Tarim Univercity, Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production&Constuction Corps, Xinjiang Alar 843300, China

Received:2012-05-07 Online:2012-07-25 Published:2012-06-11

粘细菌次生代谢产物中大环类化合物的研究进展

黄艳1,2,胡建伟2,朱红惠1*

1.广东省微生物研究所, 广东省华南应用微生物重点实验室-省部共建国家重点实验室培育基地; 广东省微生物菌种保藏与应用重点实验室, 广东省微生物新技术公共实验室, 广州 510070;

2.塔里木大学, 塔里木盆地生物资源保护利用兵团重点实验室, 新疆阿拉尔 843300

通讯作者: 朱红惠，研究员，博士,主要从事微生物资源多样性及前期应用研究。Tel:020-87686803; E-mail:zhuhonghui66@yahoo.com.cn
作者简介:黄艳,硕士研究生,研究方向为微生物次生代谢产物。E-mail:huang.yan14@qq.com。
基金资助:
国家自然科学基金项目(31170009);广东省自然科学基金项目(10151007002000008);新疆生产建设兵团塔里木盆地生物资源保护利用重点实验室开放基金课题重点项目(BRZD1004)资助。

Abstract

Abstract: Myxobacteria can produce various secondary metabolites, and hence are considered as the third group of bacteria producing secondary metabolites following Actinomyces and Bacillus. This paper presents the research advance in macrocyclic compounds of secondary metabolites from myxobacteria. This paper introduces the major kinds of macrocyclic compounds, their structure and myxobacteria strains from which they were isolated, summarizes the bioactivities from the aspects of anti-tumor, anti-bacteria, anti-fungi, and anti-virus etc, and puts forward the related researches on macrocyclic compounds of secondary metabolites from myxobacteria.

Key words: myxobacteria, secondary metabolites, macrocyclic compounds, research progress

摘要： 粘细菌可以产生多种次生代谢产物,是继放线菌、芽胞杆菌之后的第3大类次级代谢产物产生菌。本文综述了粘细菌次生代谢产物中大环类化合物的研究进展。首先介绍了粘细菌中分离的主要大环类化合物种类、结构特征及来源菌株;然后分别从抗肿瘤、抗菌、抗病毒等几方面对其生物活性进行概述;最后对粘细菌次生代谢产物中大环类化合物的相关研究工作进行了展望。

关键词: 粘细菌, 次生代谢产物, 大环类化合物, 研究进展

HUANG Yan, HU Jian-wei, ZHU Hong-hui. Research Progress in Macrocyclic Compounds of Secondary Metabolites from Myxobacteria[J]. Current Biotechnology, 2012, 2(4): 263-269.

黄艳, 胡建伟, 朱红惠. 粘细菌次生代谢产物中大环类化合物的研究进展[J]. 生物技术进展, 2012, 2(4): 263-269.

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Research Progress in Macrocyclic Compounds of Secondary Metabolites from Myxobacteria

粘细菌次生代谢产物中大环类化合物的研究进展

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