Research Progress on the Cytotoxicity and Immune Effects of Carbon-based Nanomaterials

doi:10.19586/j.2095-2341.2025.0024

Current Biotechnology ›› 2025, Vol. 15 ›› Issue (4): 615-621.DOI: 10.19586/j.2095-2341.2025.0024

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Research Progress on the Cytotoxicity and Immune Effects of Carbon-based Nanomaterials

Yimiao ZHANG(), Yuqin BIAN(), Xinbo LIU(), Jiahe PANG, Tongxuan SUN, Qiazheng DU, Wenhao XU, Tianze YIN(), Hongshu SUI()

Department of Histology and Embryology，College of Clinical and Basic Medicine，Shandong First Medical University，Jinan 250117，China

Received:2025-02-24 Accepted:2025-04-15 Online:2025-07-25 Published:2025-09-08
Contact: Tianze YIN,Hongshu SUI

碳纳米材料的细胞毒性及免疫效应研究进展

张怡淼(), 边裕钦(), 刘鑫博(), 庞佳禾, 孙同选, 杜洽政, 胥文豪, 尹天泽(), 隋宏书()

山东第一医科大学临床与基础医学院组织学与胚胎学系，济南 250117

通讯作者: 尹天泽,隋宏书
作者简介:张怡淼 E-mail: 15137335275@163.com；
边裕钦 E-mail: 1664591559@qq.com
刘鑫博 E-mail: 3050404736@qq.com第一联系人：（张怡淼、边裕钦、刘鑫博并列第一作者）
基金资助:
国家自然科学基金项目(81670004);山东第一医科大学教育教学改革项目(XM2022046);山东第一医科大学大学生创新创业训练项目(202410439043)

Abstract

Abstract:

Carbon-based nanomaterials have demonstrated extensive application prospects in fields including biomedicine， energy storage， and electronic devices， owing to their unique physicochemical properties. In recent years， significant advancements have been achieved in toxicological studies of these materials， but the mechanisms through which structural variations influence their cytotoxicity and immune effects remain not yet fully elucidated. This review systematically synthesized existing literature， meticulously comparing the performance of diverse carbon nanomaterials in both in vitro cellular assays and in vivo animal models， sorted out the structure-toxicity-immune effect relationships of carbon nanomaterials， and summarized the current research landscapes， development trends and research needs of toxicology research on carbon nanomaterials， in order to provid theoretical basis for their safety design.

Key words: cytotoxicity, carbon nanomaterials, macrophage, immune effect

摘要：

碳基纳米材料因其独特的物理化学性质在生物医学、能源存储及电子器件等领域展现出广阔的应用前景。近年来，碳纳米材料的毒理学研究取得了显著进展，但结构差异对细胞毒性及免疫效应的影响机制尚未完全明确。通过系统地分析现有文献资料，比较了多种碳纳米材料在体外细胞试验和体内动物模型中的表现，疏理了碳纳米材料的结构-毒性-免疫效应关联，总结了碳纳米材料毒理学研究的总体现状、发展趋势和研究需求，以期为其安全性设计提供理论依据。

关键词: 细胞毒性, 碳纳米材料, 巨噬细胞, 免疫效应

CLC Number:

Yimiao ZHANG, Yuqin BIAN, Xinbo LIU, Jiahe PANG, Tongxuan SUN, Qiazheng DU, Wenhao XU, Tianze YIN, Hongshu SUI. Research Progress on the Cytotoxicity and Immune Effects of Carbon-based Nanomaterials[J]. Current Biotechnology, 2025, 15(4): 615-621.

张怡淼, 边裕钦, 刘鑫博, 庞佳禾, 孙同选, 杜洽政, 胥文豪, 尹天泽, 隋宏书. 碳纳米材料的细胞毒性及免疫效应研究进展[J]. 生物技术进展, 2025, 15(4): 615-621.

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Research Progress on the Cytotoxicity and Immune Effects of Carbon-based Nanomaterials

碳纳米材料的细胞毒性及免疫效应研究进展

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