The Role of the Global Regulatory Factor LaeA in Filamentous Fungi: Mechanisms and Applications

doi:10.19586/j.2095-2341.2024.0105

Current Biotechnology ›› 2025, Vol. 15 ›› Issue (1): 27-34.DOI: 10.19586/j.2095-2341.2024.0105

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The Role of the Global Regulatory Factor LaeA in Filamentous Fungi: Mechanisms and Applications

Xianchao MENG¹^,²(), Bo HU¹, Zhe NING¹, Yuanyuan SUN¹, Haobing YU¹, Xiaoyu LIU¹()

^1.Naval Medical Center，Naval Medical University，Shanghai 200433，China
^2.School of Ocean Food and Biological Engineering，Jiangsu Ocean University，Jiangsu Lianyungang 222005，China

Received:2024-05-22 Accepted:2024-06-22 Online:2025-01-25 Published:2025-03-07
Contact: Xiaoyu LIU

全局性调控因子LaeA在丝状真菌中的作用：机制与应用

孟宪超¹^,²(), 胡波¹, 宁哲¹, 孙园园¹, 于豪冰¹, 刘小宇¹()

^1.海军军医大学海军特色医学中心，上海　200433
^2.江苏海洋大学海洋食品与生物工程学院，江苏连云港　222005

通讯作者: 刘小宇
作者简介:孟宪超 E-mail: 1239319990@qq.com；
基金资助:
国家重点研发计划项目(2022YFC2804105)

Abstract

Abstract:

Loss of aflR expression-A （LaeA） has been recognized as a crucial global regulatory factor in filamentous fungi， orchestrating the intricate balance of gene expression to govern either the developmental trajectory of strains or the synthesis and diversification of secondary metabolites. Recent advancements in bioinformatics analysis have unveiled numerous novel regulatory roles of LaeA. This review focused on elucidating the mechanisms and regulatory functions of LaeA， encompassing its structural-functional attributes and its modulation of fungal growth and secondary metabolite biosynthesis. Simultaneously， it explored the potential applications of LaeA in the fields such as drug development， agriculture， and industrial production， in order to provide reference and help in improving the yield and activity of secondary metabolites of filamentous fungi，and developing new marine drugs.

Key words: global regulator LaeA, secondary metabolism, filamentous fungi

摘要：

LaeA是丝状真菌中重要的全局性调控因子，通过调节相关基因的表达，控制菌株的生长发育或促进次级代谢产物的合成。近年来，随着生物信息学分析技术的发展，LaeA参与的新的调控作用被发现。聚焦于LaeA的作用机制和调控作用，从LaeA的结构功能、真菌生育和次级代谢产物的调节3个方面综述了LaeA在真菌中的研究进展，同时探讨了LaeA在药物研发、农业以及工业生产等领域的应用潜力，以期为提高丝状真菌次级代谢产物的产量、活性和多样性，以及开发新型的海洋药物等提供参考和借鉴。

关键词: 全局性调控因子LaeA, 次级代谢, 丝状真菌

CLC Number:

Xianchao MENG, Bo HU, Zhe NING, Yuanyuan SUN, Haobing YU, Xiaoyu LIU. The Role of the Global Regulatory Factor LaeA in Filamentous Fungi: Mechanisms and Applications[J]. Current Biotechnology, 2025, 15(1): 27-34.

孟宪超, 胡波, 宁哲, 孙园园, 于豪冰, 刘小宇. 全局性调控因子LaeA在丝状真菌中的作用：机制与应用[J]. 生物技术进展, 2025, 15(1): 27-34.

Figures/Tables 6

References 53

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属名	基因	菌种	功能	参考文献
Aspergillus	LaeA	Aspergillus sp. Z5	SM, D, V, O	[10]
	LaeA	土曲霉 Aspergillus terreus	SM, V	[6]
	LaeA	黑曲霉 Aspergillus niger	SM, D	[11-14]
	LaeA	黄曲霉 Aspergillus flavipes	SM, D, V	[15]
	ACLaeA	碳黑曲霉 Aspergillus carbonarius	SM	[16]
	LaeA	假土曲霉 Aspergillus pseudoterreus	SM	[17]
	LaeA	紫红曲霉 Monascus purpureus	SM, D	[18]
	LaeA	赭曲霉 Aspergillus ochraceus	SM, D, V	[7]
	LaeA	杂色曲霉 Aspergillus versicolor	SM, D	[19]
Magnaporthe	MoLaeA	稻热病菌 Magnaporthe oryzae	SM, D, O	[20]
Valsa	LaeA	苹果黑腐皮壳 Valsa mali	SM, D	[3]
Penicillium	LaeA	双足青霉YJ-11 Penicillium dipodomyis YJ-11	SM, D	[2]
Chaetomium	CgLaeA	球毛壳菌 Chaetomium globosum	SM, D	[21]
Cordyceps	CmLaeA	蛹虫草菌 Cordyceps militaris	SM, D	[9]
Myceliophthora	LaeA	嗜热毁丝霉 Myceliophthora thermophila	SM, D	[22]
Ganoderma	LaeA	灵芝 Ganoderma lucidum	SM, D	[23]
Trichoderma	TaLae1	非洲哈茨木霉 Trichoderma afroharzianum	SM, V, D	[8]

属名	基因	菌种	功能	参考文献
Aspergillus	LaeA	Aspergillus sp. Z5	SM, D, V, O	[10]
	LaeA	土曲霉 Aspergillus terreus	SM, V	[6]
	LaeA	黑曲霉 Aspergillus niger	SM, D	[11-14]
	LaeA	黄曲霉 Aspergillus flavipes	SM, D, V	[15]
	ACLaeA	碳黑曲霉 Aspergillus carbonarius	SM	[16]
	LaeA	假土曲霉 Aspergillus pseudoterreus	SM	[17]
	LaeA	紫红曲霉 Monascus purpureus	SM, D	[18]
	LaeA	赭曲霉 Aspergillus ochraceus	SM, D, V	[7]
	LaeA	杂色曲霉 Aspergillus versicolor	SM, D	[19]
Magnaporthe	MoLaeA	稻热病菌 Magnaporthe oryzae	SM, D, O	[20]
Valsa	LaeA	苹果黑腐皮壳 Valsa mali	SM, D	[3]
Penicillium	LaeA	双足青霉YJ-11 Penicillium dipodomyis YJ-11	SM, D	[2]
Chaetomium	CgLaeA	球毛壳菌 Chaetomium globosum	SM, D	[21]
Cordyceps	CmLaeA	蛹虫草菌 Cordyceps militaris	SM, D	[9]
Myceliophthora	LaeA	嗜热毁丝霉 Myceliophthora thermophila	SM, D	[22]
Ganoderma	LaeA	灵芝 Ganoderma lucidum	SM, D	[23]
Trichoderma	TaLae1	非洲哈茨木霉 Trichoderma afroharzianum	SM, V, D	[8]

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The Role of the Global Regulatory Factor LaeA in Filamentous Fungi: Mechanisms and Applications

全局性调控因子LaeA在丝状真菌中的作用：机制与应用

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