Abstract:

The restoration of blood supply after ischemic injury will lead to ischemia/reperfusion （IR） injury， which could lead to further aggravation of tissue injury. IR injury is accompanied by a series of mechanisms， including glutamate excitotoxicity， calcium overload， oxidative stress， inflammation and apoptosis， resulting in cell death. IR injury processes are regulated by the Sirtuins family. In the Sirtuins family， SIRT6， specifically located in the nucleus， can promote resistance to DNA damage and oxidative stress， inhibit genomic instability， and play a role in metabolic homeostasis， and SIRT6 is highly expressed in the brain. However， there are few studies on SIRT6 in brain IR injury， so combined with the latest research progress at home and abroad， we made a retrospective summary and analysis of the role of SIRT6 in IR injury， hoping to provide some reference basis for domestic and foreign scholars on the study of SIRT6 in stroke.

Key words: SIRT6, ischemic injury, ischemia reperfusion injury, cerebral stroke

摘要：

缺血性损伤后恢复血液供应会导致缺血再灌注（ischemia reperfusion, IR）损伤，这会导致组织损伤进一步加剧。IR损伤伴随着一系列机制，包括谷氨酸兴奋性毒性、钙超载、氧化应激、炎症和细胞凋亡，最终导致细胞死亡。IR损伤过程均由Sirtuins家族调控，在Sirtuins家族中，特异性定位于细胞核中的SIRT6可以促进对DNA损伤和氧化应激的抵抗，抑制基因组的不稳定性，在代谢稳态中发挥作用，同时SIRT6在人重要脏器中处于高度表达状态。但SIRT6在IR损伤中研究较少，结合国内外最新的研究进展，对SIRT6在IR损伤中的作用进行了回顾性的总结和分析，希望对国内外学者对于SIRT6在IR损伤中的研究提供一些参考依据。

关键词: SIRT6, 缺血性损伤, 缺血再灌注损伤, 脑卒中