Analysis of Genetic Polymorphisms at 37 Y⁃STR Loci in Dezhou Han Population

doi:10.19586/j.2095-2341.2021.0148

Current Biotechnology ›› 2022, Vol. 12 ›› Issue (2): 288-295.DOI: 10.19586/j.2095-2341.2021.0148

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Analysis of Genetic Polymorphisms at 37 Y⁃STR Loci in Dezhou Han Population

Longfei MIAO¹(), Dapeng SUN¹, Wenhua MA²(), Jianjun ZHONG¹()

^1.Material Evidence Authentication and Research Center，Dezhou Public Security Bureau，Shandong Dezhou 253000，China
^2.Institute of Forensic Science，Ministry of Public Security，Beijing 100038，China

Received:2021-09-03 Accepted:2021-11-08 Online:2022-03-25 Published:2022-03-25
Contact: Wenhua MA,Jianjun ZHONG

德州汉族人群37个Y⁃STR基因座遗传多态性分析

苗龙飞¹(), 孙大鹏¹, 马温华²(), 仲建军¹()

^1.德州市公安局物证鉴定研究中心，山东德州 253000
^2.公安部物证鉴定中心，北京 100038

通讯作者: 马温华,仲建军
作者简介:苗龙飞 E-mail:413695507@qq.com
基金资助:
法医遗传学公安部重点实验室开放课题(2018FGKFKT05)

Abstract

Abstract:

To investigate the genetic polymorphism of 37 Y-STR loci in 598 unrelated male individuals of Dezhou Han population，and to explore its application value in forensic medicine and population genetics. The 37 Y-STR loci were amplified by AGCU Y37 kit， and the amplification products were analyzed through 3500xL genetic analyzer. The phylogenetic tree of Dezhou Han population and other 15 reference populations was constructed by Neighbor Joining （NJ） with MEGA 7.0 software to explore the genetic relationship. The results showed that 593 different haplotypes were observed in 598 unrelated male individuals. The genetic diversity （GD） ranged from 0.113 9（DYS645） to 0.971 4（DYS385a/b）. The haplotype diversity（HD） and discriminative capacity（DC） were 0.999 971 989 and 0.991 6， respectively， which showed that the 37 Y-STR loci were highly polymorphic in Dezhou Han population. The results of genetic distance， multidimensional scaling （MDS） and phylogenetic tree indicated that the genetic distance between Dezhou Han population and other Han populations was close in population genetic analysis， and the genetic characteristics of different populations were consistent with language family， historical formation and geographical distribution. The results obtained in this study can provide basic data support for forensic science and population genetics research of Dezhou Han population.

Key words: forensic medicine, Y-STR loci, genetic polymorphism, Dezhou Han population

摘要：

调查德州汉族人群598名男性无关个体37个Y-STR基因座的遗传多态性，分析其在法医学和群体遗传学方面的应用价值，用AGCU Y37荧光检测试剂盒对德州汉族群体的37个Y-STR基因座进行扩增，用3500xL基因分析仪对其进行检测。用MEGA 7.0软件，通过邻接法（neighbor-joining, NJ）构建德州汉族群体和其他15个参考群体的系统发生树，探索群体间的遗传关系。结果共检出593种单倍型，基因多样性（genetic diversity, GD）值为0.113 9（DYS645）～0.971 4（DYS385a/b），单倍型多样性（haplotype diversity， HD）和识别能力（discriminative capacity， DC）分别为0.999 971 989和0.991 6。结果表明，这37个Y-STR基因座在德州汉族人群中有较高的多态性分布。群体遗传分析中，遗传距离、多维尺度分析( multi-dimensional scaling，MDS) 和系统发生树分析结果表明，德州汉族与其他地区的汉族群体遗传距离更近。不同群体的遗传特征与语系划分、历史形成、地理分布等方面具有一致性。研究结果可为德州汉族人群的法庭科学和群体遗传学研究提供基础数据支持。

关键词: 法医学, Y-STR基因座, 遗传多态性, 德州汉族

CLC Number:

Longfei MIAO, Dapeng SUN, Wenhua MA, Jianjun ZHONG. Analysis of Genetic Polymorphisms at 37 Y⁃STR Loci in Dezhou Han Population[J]. Current Biotechnology, 2022, 12(2): 288-295.

苗龙飞, 孙大鹏, 马温华, 仲建军. 德州汉族人群37个Y⁃STR基因座遗传多态性分析[J]. 生物技术进展, 2022, 12(2): 288-295.

Figures/Tables 5

References 28

1	郑秀芬. 法医DNA分析[M]. 北京:中国人民公安大学出版社, 2002: 300-301.
2	KAYSER M. The Human Y-chromosome-introduction into genetics and applications [J]. Forensic Sci. Rev., 2003, 15(2): 77-89.
3	ROEWER L, NURNBERG P, FUHRMANN E, et al.. Stain analysis using oligonucleotide probes specific for simple repetitive DNA sequences [J]. Forensic Sci. Int., 1990, 47(1): 59-70.
4	KAYSER M, BRAUER S, WEISS G, et al.. Independent histories of human Y chromosomes from Melanesia and Australia[J]. Am. J. Hum. Genet., 2001, 68(1): 173-190.
5	KAYSER M, BRAUER S, WEISS G, et al.. Melanesian origin of polynesian Y chromosomes [J]. Curr. Biol., 2000, 10(20): 1237-1246.
6	JOBLING M A, TYLER-SMITH C. Father and sons: the Y chromosome and human evolution[J]. Trends Genet., 1995,11:449-456.
7	师文远, 王瑛, 李海霞, 等. 基于Y-STR分型的中国汉族群体遗传关系[J]. 热带医学杂志, 2016,16(3):281-284.
8	邓盼, 江丽, 马泉, 等. 广西6个民族24个Y-STR基因座遗传多态性及群体遗传结构分析[J]. 刑事技术, 2018,43(3 ):198-201.
9	尚蕾, 莫晓婷, 张建, 等. 周口地区汉族人群26个Y-STR基因座的遗传多态性[J]. 激光生物学报, 2018, 27(1): 91-96.
10	孟娟, 王晓丹, 黄艳梅, 等. 河南新乡地区汉族人群27个Y-STR基因座遗传多态性检测[J].郑州大学学报, 2018, 53(4): 452-457.
11	赵霖, 李晓明, 付永, 等. 湖南长沙汉族人群25个Y-STR基因座的遗传多态性[J]. 法医学杂志, 2018, 34(1): 79-81.
12	刘亚举, 孙现锋, 岳俊涛, 等. 中国汉族群体36个Y-STR基因座的遗传多态性及突变研究[J].中国输血杂志, 2018, 31(5):495-499.
13	ZEYE M M J, LI J, OUEDRAOGO S Y, et al.. Population data and genetic structure analysis based on 29 Y-STR loci among the ethnolinguistic groups in Burkina Faso[J]. Int. J. Legal Med., 2021,135(5): 1767-1769.
14	KUMAR S, STECHER G, TAMURA K. MEGA7: molecular evolutionary genetics analysis Version 7.0 for bigger datasets[J]. Mol. Biol. Evol., 2016,33(7) : 1870-1874.
15	SAITOU N,NEI M. The neighbor-joining method: a new method for reconstructing phylogenetic trees[J]. Mol.Biol.Evol.,1987, 4: 406-425.
16	ALGHAFRI R, ZUPANIC P I, ZUPANC T, et al.. Rapidly mutating Y-STR analyses of compromised forensic samples [J]. Int. J. Legal. Med., 2018, 132(2): 397-403.
17	BALLANTYNE K N, KEEL V, WOLLSTEIN A, et al.. A new future of forensic Y-chromosome analysis: rapidly mutating Y-STRs for differentiating male relatives and paternal lineages[J]. Forensic Sci. Int. Genet.,2012,6(2):208-218.
18	吴微微, 张晓霞, 金雷, 等. 中国汉族男性家系Y-STR 基因座容差情况调查[J].中国法医学杂志, 2020,35(4):390-393.
19	ZHANG F, SU B, ZHANG Y, et al.. Genetic studies of human diversity in East Asia [J]. Phil. Trans. R. Soc. B, 2007, 362(1482): 987-996.
20	蔡晓云.Y染色体揭示的早期人类进入东亚和东亚人群特征形成过程[D].上海:复旦大学, 2009.
21	ROSENBERG N A, PRITECHARD J K, WEBER J L, et al.. Genetic structure of human populations[J]. Science, 2002,298(5602):2381-2385.
22	ATKINSON Q D. Phonemic diversity supports a serial founder effect model of language expansion from Africa[J]. Science, 2011, 332(6027): 346-349.
23	许正文.论历史时期大陆向台湾的移民与往来[J].中国历史地理论丛, 2001(16)3:67-71.
24	张绚光. 二十世纪后半期回族史学论述[D]. 兰州: 兰州大学, 2012.
25	ROSENBERG N A, PRITCHARD J K, WEBER J L, et a1.. Genetics structure of human populations[J]. Science, 2002, 298(5602): 2381-2385.
26	ROSENBERG N A, MAHAJAN S, RAMACHANDRAN S,et a1.. Clines,clusters,and the effect of study design on the inference of human populations structure[J]. PLoS Genet., 2005, 1(6): 660-671.
27	SHRIVER M D, MEI R, PARRA E J,et a1..Largescale SNP analysis reveals clustered and continuous patterns of human genetic variation[J]. Hum. Genom., 2005, 2(2):81-89.
28	KAYSER M, KRAWCZAK M, EXCOFFIER L, et al.. An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human population[J]. Am. J. Hum. Genet., 2001,68:990-1018.

DYS19		DYS447		DYS533		DYS596		DYS576
A	F	A	F	A	F	A	F	A	F
12	0.001 7	21	0.003 3	9	0.006 7	13	0.006 7	14	0.005 0
13	0.055 2	22	0.015 1	10	0.063 5	14	0.361 2	15	0.006 7
14	0.232 4	23	0.232 4	11	0.521 7	15	0.453 2	16	0.068 6
15	0.381 3	24	0.239 1	12	0.329 4	16	0.157 2	17	0.214 0
15,17	0.001 7	25	0.187 3	13	0.065 2	17	0.013 4	18	0.337 8
16	0.250 8	26	0.142 1	14	0.013 4	18	0.008 4	19	0.234 1
17	0.071 9	27	0.123 7	DYS444		DYS593		20	0.080 3
18	0.005 0	28	0.036 8	A	F	A	F	21	0.045 2
DYS389I		29	0.018 4	8	0.001 7	12	0.001 7	21,22	0.001 7
A	F	30	0.001 7	10	0.001 7	14	0.001 7	22	0.005 0
11	0.008 4	DYS449		11	0.085 3	14.2	0.001 7	24	0.001 7
12	0.500 0	A	F	12	0.321 1	15	0.319 4	DYS438
13	0.299 3	25	0.006 7	13	0.416 4	16	0.464 9	A	F
14	0.185 6	26	0.011 7	14	0.148 8	17	0.202 3	8	0.023 4
15	0.006 7	27	0.045 2	15	0.023 4	18	0.008 4	9	0.011 7
DYS389Ⅱ		27,28	0.001 7	16	0.0017	DYS635		10	0.680 6
A	F	28	0.083 6	DYS557		A	F	11	0.202 3
24	0.001 7	29	0.100 3	A	F	18	0.003 3	12	0.066 9
26	0.005 0	30	0.162 2	13	0.041 8	19	0.102 0	13	0.015 1
27	0.087 0	31	0.180 6	14	0.279 3	20	0.239 1	DYS439
28	0.304 3	32	0.157 2	15	0.219 1	21	0.352 8	A	F
29	0.277 6	33	0.135 5	16	0.209 0	22	0.175 6	9	0.005 0
30	0.225 8	33.1	0.001 7	17	0.142 1	23	0.088 6	10	0.075 3
31	0.070 2	33.2	0.001 7	17.1	0.005 0	24	0.030 1	11	0.423 1
32	0.028 4	34	0.056 9	18	0.043 5	25	0.006 7	12	0.372 9
DYS390		35	0.046 8	19	0.045 2	26	0.001 7	13	0.108 7
A	F	36	0.006 7	20	0.013 4	DYS643		14	0.011 7
19	0.001 7	40	0.001 7	21	0.001 7	A	F	15	0.001 7
20	0.001 7	DYS456		DYS570		7	0.006 7	16	0.001 7
21	0.003 3	A	F	A	F	8	0.035 1	DYS385a/b
22	0.035 1	13	0.025 1	14	0.018 4	9	0.098 7	A	F
23	0.431 4	14	0.180 6	15	0.028 4	10	0.314 4	12,17	0.070 2
24	0.316 1	15	0.526 8	16	0.180 6	11	0.408 0	13	0.053 5
25	0.192 3	16	0.205 7	17	0.224 1	12	0.115 4	12,19	0.051 8
26	0.015 1	17	0.055 2	18	0.250 8	13	0.021 7	13,19	0.040 1
27	0.003 3	18	0.006 7	19	0.190 6	DYS645		13,18	0.038 5
DYS391		DYS458		20	0.061 9	A	F	12,18	0.038 5
A	F	A	F	20.3	0.003 3	7	0.003 3	11,18	0.038 5
6	0.008 4	12	0.001 7	21	0.028 4	8	0.939 8	12,16	0.038 5
8	0.005 0	14	0.030 1	22	0.011 7	9	0.055 2	12,13	0.035 1
9	0.065 2	15	0.100 3	23	0.001 7	10	0.001 7	12	0.035 1
续表
DYS391		DYS458		DYF387S1		GATA_H4		DYS385a/b
A	F	A	F	A	F	A	F	A	F
10	0.744 1	16	0.189 0	36,38	0.105 4	10	0.063 5	13,20	0.031 8
11	0.173 9	17	0.282 6	35,39	0.073 6	11	0.341 1	12,15	0.030 1
12	0.003 3	18	0.215 7	38	0.068 6	12	0.525 1	13,16	0.026 8
DYS392		19	0.107 0	35,38	0.066 9	13	0.066 9	11,17	0.025 1
A	F	20	0.053 5	39	0.060 2	14	0.003 3	14,19	0.023 4
7	0.001 7	21	0.011 7	37	0.055 2	DYS527a/b		11,19	0.023 4
10	0.020 1	22	0.005 0	37,38	0.048 5	A	F	11,16	0.023 4
11	0.162 2	23	0.003 3	36,39	0.043 5	21	0.102 0	11,12	0.023 4
12	0.173 9	DYS460		36,37	0.043 5	21,23	0.095 3	11	0.021 7
13	0.329 4	A	F	35,37	0.043 5	20,23	0.085 3	11,13	0.021 7
14	0.269 2	8	0.005 0	37,39	0.035 1	22	0.075 3	14,18	0.020 1
15	0.038 5	9	0.275 9	36	0.031 8	21,22	0.073 6	14,17	0.020 1
16	0.005 0	10	0.408 0	36,40	0.025 1	23	0.071 9	12,20	0.018 4
DYS393		11	0.280 9	38,40	0.023 4	22,23	0.065 2	15,17	0.016 7
A	F	12	0.030 1	38,39	0.023 4	20,22	0.050 2	11,20	0.015 1
8	0.001 7	DYS481		35,40	0.020 1	19,20	0.050 2	11,14	0.013 4
11	0.005 0	A	F	39,40	0.020 1	20,24	0.041 8	15,20	0.013 4
12	0.526 8	19	0.003 3	35	0.018 4	21,24	0.028 4	13,21	0.011 7
12,14	0.001 7	20	0.015 1	40	0.016 7	20	0.026 8	16,19	0.011 7
13	0.239 1	21	0.041 8	37,40	0.016 7	22,24	0.026 8	13,17	0.010 0
14	0.158 9	22	0.145 5	35,36	0.013 4	19,21	0.025 1	13,14	0.010 0
15	0.060 2	23	0.269 2	40,41	0.013 4	19,23	0.021 7	15,22	0.010 0
16	0.006 7	24	0.239 1	36,41	0.011 7	20,21	0.020 1	15,23	0.008 4
DYS437		25	0.155 5	34	0.010 0	21,25	0.020 1	10,19	0.008 4
A	F	25.1	0.001 7	34,39	0.010 0	24	0.015 1	10,17	0.008 4
11	0.003 3	26	0.068 6	35,41	0.008 4	19,22	0.011 7	14	0.006 7
13	0.010 0	27	0.028 4	34,38	0.008 4	19	0.010 0	14,16	0.006 7
14	0.607 0	28	0.015 1	37,41	0.008 4	20,25	0.008 4	12,14	0.006 7
15	0.364 5	28.1	0.001 7	38,41	0.008 4	23,24	0.008 4	13,15	0.006 7
16	0.015 1	29	0.010 0	34,37	0.006 7	21,22,23	0.006 7	16	0.006 7
DYS448		30	0.005 0	34,40	0.005 0	18,24	0.006 7	15,16	0.005 0
A	F	DYS518		41	0.005 0	18,20	0.005 0	15,19	0.005 0
17	0.040 1	A	F	36,37,38	0.005 0	22,23,24	0.005 0	10,12	0.005 0
18	0.155 5	32	0.005 0	36,37,40	0.003 3	21.2,23	0.005 0	15,21	0.005 0
19	0.408 0	33	0.015 1	39,41	0.003 3	18,26	0.005 0	12,21	0.005 0
20	0.252 5	34	0.031 8	38,42	0.003 3	19,24	0.003 3	16,21	0.005 0
21	0.118 7	35	0.113 7	35,37,38	0.003 3	18,21	0.003 3	14,15	0.005 0
22	0.023 4	36	0.148 8	37,39,40	0.003 3	19,21,23	0.003 3	10,18	0.005 0
23	0.001 7	36.2	0.015 1	38,38	0.003 3	23,25	0.001 7	13,22	0.003 3
DYS627		37	0.158 9	37,38,39	0.003 3	20,21,24	0.001 7	16,20	0.003 3
A	F	37.2	0.028 4	34,35,37	0.003 3	14.3,22	0.001 7	12,22	0.003 3
16	0.006 7	38	0.152 2	37,38,40	0.001 7	18,19,20	0.001 7	18,19	0.003 3
续表
DYS627		DYS518		DYF387S1		DYS527a/b		DYS385a/b
A	F	A	F	A	F	A	F	A	F
17	0.038 5	38,39	0.001 7	33	0.001 7	15.3,23	0.001 7	14,24	0.003 3
18	0.085 3	38.2	0.005 0	36,38,39	0.001 7	18,23	0.001 7	11,21	0.003 3
19	0.108 7	39	0.148 8	37,40,41	0.001 7	21,22,23,24	0.001 7	17,18	0.001 7
19.2	0.001 7	40	0.100 3	35,36,39	0.001 7	33	0.001 7	13,14,20	0.001 7
20	0.183 9	41	0.046 8	36,43	0.001 7	19,20,22	0.001 7	10,15	0.001 7
20,21	0.001 7	42	0.023 4	37,40,42	0.001 7	25	0.001 7	10,21	0.001 7
21	0.250 8	43	0.005 0	33,38	0.001 7	24,26	0.001 7	12,23	0.001 7
21,22	0.001 7	DYS549		36,37,39,40	0.001 7	23,26	0.001 7	15,18	0.001 7
22	0.177 3	A	F	34,42	0.001 7	22,25	0.001 7	11,15	0.001 7
23	0.087 0	11	0.088 6	36,40,41	0.001 7	22,23.1	0.001 7	13,17,19	0.001 7
24	0.050 2	12	0.533 4	34,36	0.001 7			12,24	0.001 7
25	0.005 0	13	0.269 2					16,23	0.001 7
26	0.001 7	14	0.090 3					17,20	0.001 7
		15	0.018 4					7,12	0.001 7

DYS19		DYS447		DYS533		DYS596		DYS576
A	F	A	F	A	F	A	F	A	F
12	0.001 7	21	0.003 3	9	0.006 7	13	0.006 7	14	0.005 0
13	0.055 2	22	0.015 1	10	0.063 5	14	0.361 2	15	0.006 7
14	0.232 4	23	0.232 4	11	0.521 7	15	0.453 2	16	0.068 6
15	0.381 3	24	0.239 1	12	0.329 4	16	0.157 2	17	0.214 0
15,17	0.001 7	25	0.187 3	13	0.065 2	17	0.013 4	18	0.337 8
16	0.250 8	26	0.142 1	14	0.013 4	18	0.008 4	19	0.234 1
17	0.071 9	27	0.123 7	DYS444		DYS593		20	0.080 3
18	0.005 0	28	0.036 8	A	F	A	F	21	0.045 2
DYS389I		29	0.018 4	8	0.001 7	12	0.001 7	21,22	0.001 7
A	F	30	0.001 7	10	0.001 7	14	0.001 7	22	0.005 0
11	0.008 4	DYS449		11	0.085 3	14.2	0.001 7	24	0.001 7
12	0.500 0	A	F	12	0.321 1	15	0.319 4	DYS438
13	0.299 3	25	0.006 7	13	0.416 4	16	0.464 9	A	F
14	0.185 6	26	0.011 7	14	0.148 8	17	0.202 3	8	0.023 4
15	0.006 7	27	0.045 2	15	0.023 4	18	0.008 4	9	0.011 7
DYS389Ⅱ		27,28	0.001 7	16	0.0017	DYS635		10	0.680 6
A	F	28	0.083 6	DYS557		A	F	11	0.202 3
24	0.001 7	29	0.100 3	A	F	18	0.003 3	12	0.066 9
26	0.005 0	30	0.162 2	13	0.041 8	19	0.102 0	13	0.015 1
27	0.087 0	31	0.180 6	14	0.279 3	20	0.239 1	DYS439
28	0.304 3	32	0.157 2	15	0.219 1	21	0.352 8	A	F
29	0.277 6	33	0.135 5	16	0.209 0	22	0.175 6	9	0.005 0
30	0.225 8	33.1	0.001 7	17	0.142 1	23	0.088 6	10	0.075 3
31	0.070 2	33.2	0.001 7	17.1	0.005 0	24	0.030 1	11	0.423 1
32	0.028 4	34	0.056 9	18	0.043 5	25	0.006 7	12	0.372 9
DYS390		35	0.046 8	19	0.045 2	26	0.001 7	13	0.108 7
A	F	36	0.006 7	20	0.013 4	DYS643		14	0.011 7
19	0.001 7	40	0.001 7	21	0.001 7	A	F	15	0.001 7
20	0.001 7	DYS456		DYS570		7	0.006 7	16	0.001 7
21	0.003 3	A	F	A	F	8	0.035 1	DYS385a/b
22	0.035 1	13	0.025 1	14	0.018 4	9	0.098 7	A	F
23	0.431 4	14	0.180 6	15	0.028 4	10	0.314 4	12,17	0.070 2
24	0.316 1	15	0.526 8	16	0.180 6	11	0.408 0	13	0.053 5
25	0.192 3	16	0.205 7	17	0.224 1	12	0.115 4	12,19	0.051 8
26	0.015 1	17	0.055 2	18	0.250 8	13	0.021 7	13,19	0.040 1
27	0.003 3	18	0.006 7	19	0.190 6	DYS645		13,18	0.038 5
DYS391		DYS458		20	0.061 9	A	F	12,18	0.038 5
A	F	A	F	20.3	0.003 3	7	0.003 3	11,18	0.038 5
6	0.008 4	12	0.001 7	21	0.028 4	8	0.939 8	12,16	0.038 5
8	0.005 0	14	0.030 1	22	0.011 7	9	0.055 2	12,13	0.035 1
9	0.065 2	15	0.100 3	23	0.001 7	10	0.001 7	12	0.035 1
续表
DYS391		DYS458		DYF387S1		GATA_H4		DYS385a/b
A	F	A	F	A	F	A	F	A	F
10	0.744 1	16	0.189 0	36,38	0.105 4	10	0.063 5	13,20	0.031 8
11	0.173 9	17	0.282 6	35,39	0.073 6	11	0.341 1	12,15	0.030 1
12	0.003 3	18	0.215 7	38	0.068 6	12	0.525 1	13,16	0.026 8
DYS392		19	0.107 0	35,38	0.066 9	13	0.066 9	11,17	0.025 1
A	F	20	0.053 5	39	0.060 2	14	0.003 3	14,19	0.023 4
7	0.001 7	21	0.011 7	37	0.055 2	DYS527a/b		11,19	0.023 4
10	0.020 1	22	0.005 0	37,38	0.048 5	A	F	11,16	0.023 4
11	0.162 2	23	0.003 3	36,39	0.043 5	21	0.102 0	11,12	0.023 4
12	0.173 9	DYS460		36,37	0.043 5	21,23	0.095 3	11	0.021 7
13	0.329 4	A	F	35,37	0.043 5	20,23	0.085 3	11,13	0.021 7
14	0.269 2	8	0.005 0	37,39	0.035 1	22	0.075 3	14,18	0.020 1
15	0.038 5	9	0.275 9	36	0.031 8	21,22	0.073 6	14,17	0.020 1
16	0.005 0	10	0.408 0	36,40	0.025 1	23	0.071 9	12,20	0.018 4
DYS393		11	0.280 9	38,40	0.023 4	22,23	0.065 2	15,17	0.016 7
A	F	12	0.030 1	38,39	0.023 4	20,22	0.050 2	11,20	0.015 1
8	0.001 7	DYS481		35,40	0.020 1	19,20	0.050 2	11,14	0.013 4
11	0.005 0	A	F	39,40	0.020 1	20,24	0.041 8	15,20	0.013 4
12	0.526 8	19	0.003 3	35	0.018 4	21,24	0.028 4	13,21	0.011 7
12,14	0.001 7	20	0.015 1	40	0.016 7	20	0.026 8	16,19	0.011 7
13	0.239 1	21	0.041 8	37,40	0.016 7	22,24	0.026 8	13,17	0.010 0
14	0.158 9	22	0.145 5	35,36	0.013 4	19,21	0.025 1	13,14	0.010 0
15	0.060 2	23	0.269 2	40,41	0.013 4	19,23	0.021 7	15,22	0.010 0
16	0.006 7	24	0.239 1	36,41	0.011 7	20,21	0.020 1	15,23	0.008 4
DYS437		25	0.155 5	34	0.010 0	21,25	0.020 1	10,19	0.008 4
A	F	25.1	0.001 7	34,39	0.010 0	24	0.015 1	10,17	0.008 4
11	0.003 3	26	0.068 6	35,41	0.008 4	19,22	0.011 7	14	0.006 7
13	0.010 0	27	0.028 4	34,38	0.008 4	19	0.010 0	14,16	0.006 7
14	0.607 0	28	0.015 1	37,41	0.008 4	20,25	0.008 4	12,14	0.006 7
15	0.364 5	28.1	0.001 7	38,41	0.008 4	23,24	0.008 4	13,15	0.006 7
16	0.015 1	29	0.010 0	34,37	0.006 7	21,22,23	0.006 7	16	0.006 7
DYS448		30	0.005 0	34,40	0.005 0	18,24	0.006 7	15,16	0.005 0
A	F	DYS518		41	0.005 0	18,20	0.005 0	15,19	0.005 0
17	0.040 1	A	F	36,37,38	0.005 0	22,23,24	0.005 0	10,12	0.005 0
18	0.155 5	32	0.005 0	36,37,40	0.003 3	21.2,23	0.005 0	15,21	0.005 0
19	0.408 0	33	0.015 1	39,41	0.003 3	18,26	0.005 0	12,21	0.005 0
20	0.252 5	34	0.031 8	38,42	0.003 3	19,24	0.003 3	16,21	0.005 0
21	0.118 7	35	0.113 7	35,37,38	0.003 3	18,21	0.003 3	14,15	0.005 0
22	0.023 4	36	0.148 8	37,39,40	0.003 3	19,21,23	0.003 3	10,18	0.005 0
23	0.001 7	36.2	0.015 1	38,38	0.003 3	23,25	0.001 7	13,22	0.003 3
DYS627		37	0.158 9	37,38,39	0.003 3	20,21,24	0.001 7	16,20	0.003 3
A	F	37.2	0.028 4	34,35,37	0.003 3	14.3,22	0.001 7	12,22	0.003 3
16	0.006 7	38	0.152 2	37,38,40	0.001 7	18,19,20	0.001 7	18,19	0.003 3
续表
DYS627		DYS518		DYF387S1		DYS527a/b		DYS385a/b
A	F	A	F	A	F	A	F	A	F
17	0.038 5	38,39	0.001 7	33	0.001 7	15.3,23	0.001 7	14,24	0.003 3
18	0.085 3	38.2	0.005 0	36,38,39	0.001 7	18,23	0.001 7	11,21	0.003 3
19	0.108 7	39	0.148 8	37,40,41	0.001 7	21,22,23,24	0.001 7	17,18	0.001 7
19.2	0.001 7	40	0.100 3	35,36,39	0.001 7	33	0.001 7	13,14,20	0.001 7
20	0.183 9	41	0.046 8	36,43	0.001 7	19,20,22	0.001 7	10,15	0.001 7
20,21	0.001 7	42	0.023 4	37,40,42	0.001 7	25	0.001 7	10,21	0.001 7
21	0.250 8	43	0.005 0	33,38	0.001 7	24,26	0.001 7	12,23	0.001 7
21,22	0.001 7	DYS549		36,37,39,40	0.001 7	23,26	0.001 7	15,18	0.001 7
22	0.177 3	A	F	34,42	0.001 7	22,25	0.001 7	11,15	0.001 7
23	0.087 0	11	0.088 6	36,40,41	0.001 7	22,23.1	0.001 7	13,17,19	0.001 7
24	0.050 2	12	0.533 4	34,36	0.001 7			12,24	0.001 7
25	0.005 0	13	0.269 2					16,23	0.001 7
26	0.001 7	14	0.090 3					17,20	0.001 7
		15	0.018 4					7,12	0.001 7

基因座	GD值	基因座	GD值	基因座	GD值	基因座	GD值	基因座	GD值
DYS385a/b	0.971 4	DYS447	0.817 6	DYS392	0.761 8	DYS439	0.665 4	DYS533	0.611 8
DYF387S1	0.953 8	DYS458	0.813 8	DYS19	0.730 7	DYS456	0.645 0	GATA_H4	0.600 4
DYS527a/b	0.942 3	DYS570	0.813 3	DYS448	0.730 5	DYS593	0.641 9	DYS437	0.499 1
DYS518	0.880 7	DYS557	0.805 6	DYS643	0.711 1	DYS596	0.640 2	DYS438	0.491 3
DYS449	0.874 7	DYS576	0.773 3	DYS444	0.694 7	DYS393	0.637 5	DYS391	0.412 3
DYS627	0.842 5	DYS635	0.769 6	DYS460	0.678 7	DYS549	0.627 7	DYS645	0.113 9
DYS481	0.818 5	DYS38Ⅱ	0.767 3	DYS390	0.676 6	DYS389I	0.626 9

基因座	GD值	基因座	GD值	基因座	GD值	基因座	GD值	基因座	GD值
DYS385a/b	0.971 4	DYS447	0.817 6	DYS392	0.761 8	DYS439	0.665 4	DYS533	0.611 8
DYF387S1	0.953 8	DYS458	0.813 8	DYS19	0.730 7	DYS456	0.645 0	GATA_H4	0.600 4
DYS527a/b	0.942 3	DYS570	0.813 3	DYS448	0.730 5	DYS593	0.641 9	DYS437	0.499 1
DYS518	0.880 7	DYS557	0.805 6	DYS643	0.711 1	DYS596	0.640 2	DYS438	0.491 3
DYS449	0.874 7	DYS576	0.773 3	DYS444	0.694 7	DYS393	0.637 5	DYS391	0.412 3
DYS627	0.842 5	DYS635	0.769 6	DYS460	0.678 7	DYS549	0.627 7	DYS645	0.113 9
DYS481	0.818 5	DYS38Ⅱ	0.767 3	DYS390	0.676 6	DYS389I	0.626 9

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16
1		+	+	+	+	+	-	+	+	+	+	+	+	+	+	-
2	0.103 1		+	+	+	+	+	+	+	+	+	+	+	+	+	+
3	0.063 7	0.055 1		+	+	+	+	+	+	+	+	+	+	-	+	+
4	0.016 1	0.070 2	0.056 3		+	+	+	+	+	+	+	+	+	+	+	+
5	0.014 9	0.152 9	0.100 2	0.028 2		+	+	+	+	+	+	+	+	+	+	-
6	0.006 0	0.111 0	0.071 8	0.012 6	0.006 9		+	+	+	+	+	+	+	+	+	-
7	0.012 1	0.107 0	0.075 9	0.011 6	0.015 9	0.002 8		+	+	+	+	+	+	+	+	-
8	0.004 9	0.108 7	0.065 0	0.015 1	0.010 5	0.011 4	0.023 4		-	+	+	+	+	+	+	-
9	0.002 9	0.099 2	0.066 5	0.016 3	0.012 0	0.008 3	0.015 4	0.003 7		+	+	+	+	+	+	-
10	0.032 2	0.066 7	0.007 1	0.030 1	0.060 5	0.039 9	0.045 7	0.030 5	0.036 0		+	+	+	+	+	+
11	0.075 7	0.092 6	0.092 1	0.029 6	0.087 5	0.049 7	0.036 4	0.087 8	0.076 2	0.072 3		+	+	+	+	+
12	0.040 1	0.029 3	0.031 3	0.031 2	0.073 0	0.053 3	0.060 3	0.035 9	0.039 2	0.025 2	0.088 9		+	+	+	+
13	0.052 3	0.119 2	0.087 1	0.049 3	0.072 8	0.051 0	0.046 4	0.071 4	0.063 0	0.064 0	0.072 3	0.075 3		+	+	+
14	0.067 2	0.080 5	0.003 3	0.068 7	0.107 7	0.078 0	0.085 3	0.063 6	0.068 0	0.006 1	0.117 2	0.044 6	0.103 7		+	+
15	0.011 5	0.105 3	0.075 5	0.010 0	0.010 6	0.001 6	0.002 0	0.018 5	0.011 9	0.045 3	0.044 6	0.053 4	0.054 7	0.085 7		-
16	0.009 1	0.166 4	0.104 6	0.042 5	0.008 1	0.008 1	0.014 1	0.015 4	0.010 9	0.064 4	0.106 5	0.090 8	0.073 6	0.101 1	0.016 0

Analysis of Genetic Polymorphisms at 37 Y⁃STR Loci in Dezhou Han Population

德州汉族人群37个Y⁃STR基因座遗传多态性分析

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