Curr. Biotech. ›› 2019, Vol. 9 ›› Issue (1): 21-27.DOI: 10.19586/j.2095-2341.2018.0101

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Function of Glucose Transporter in the Regulation of Blood Glucose Homeostasis

ZHANG Kaiyi, XIE Ning, YE Huaqiong, YANG Shulin   

  1. 1.Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2.Department of Animal Science, Anhui Science and Technology University, Anhui Chuzhou 233100, China
  • Received:2018-10-09 Online:2019-01-25 Published:2018-11-26

葡萄糖转运蛋白在血糖稳态调节中的功能

张凯艺1,谢宁1,叶华琼1,2,杨述林1*   

  1. 1.中国农业科学院北京畜牧兽医研究所, 北京 100193;
    2.安徽科技学院动物科学学院, 安徽 滁州 233100
  • 通讯作者: 杨述林，研究员，研究方向为小型猪糖尿病模型。E-mail: yangshulin@caas.cn
  • 作者简介:张凯艺，硕士研究生，研究方向为小型猪糖尿病模型。E-mail：41081359@qq.com。
  • 基金资助:
    国家自然科学基金项目（81770832）；国家转基因生物新品种培育重大专项（2016ZX08010-003）；中国农业科学院科技创新工程项目（ASTIP-IAS05）资助。

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Abstract: Glucose transport depends on glucose transporter (GluT), which is the major step of tissue glucose metabolism and blood glucose homeostasis. Class I of GluT family is closely related to metabolic diseases such as T2DM. This paper reviewed the characteristics and functions of Class I of GluT and how they participate in glucose metabolism, blood glucose homeostasis and pathological process of T2DM. The paper also analyzed the characteristics, division and the relationship of the tissues and organs in glycose metabolism. The paper was expected to show new view on diagnosis and treatment of T2DM and related diseases, furthermore, provide new ideas for exploring potential drug target.

Key words: glucose transporter, blood glucose homeostasis, type 2 diabetes mellitus

摘要： 葡萄糖转运蛋白（glucose transporter, GluT）介导的葡萄糖跨膜运输是组织葡萄糖代谢和血糖调节中的重要步骤，其中GluT家族Ⅰ组成员与2型糖尿病（type 2 diabetes mellitus, T2DM）等代谢疾病关系尤为密切。从血糖整体调节的角度出发，对Ⅰ组GluT在血糖稳态调节关键组织的生理、病理过程中发挥的作用进行阐述，并进一步分析了Ⅰ组GluT的特性、分工以及各组织器官在机体糖代谢中的相互关系，以期为T2DM等代谢疾病的诊断、治疗和模型构建展现新视角，并为开发潜在的药物靶点提供新思路。

关键词: 葡萄糖转运蛋白, 血糖稳态, 2型糖尿病

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