Abstract: To prepare and evaluate the hemostatic that made of corn microporous starch, a sequential hydrochloric acid and composite enzyme hydrolysis method was utilized for preparation of corn microporous starch. The density and water-absorbing ratio of the microporous starch were determined. The hemostatic effect was evaluated by animal wound hemorrhage model. Results showed that, the density and water-absorbing ratio of the microporous starch were determined to be 3.4×104 /mm2 and 156.98%, respectively. The microorganism and endotoxin had  been picked out. The hemostatic time of the microporous starch to the rabbit ear and liver trauma were within 140 s and 80 s, and the hemostasis effect was superior to Yunnan Baiyao. The microporous starch had good biocompatibility and met the safety criterion of biomaterial. It has potential to be a promising biomaterial for hemostasis.

Key words: corn starch, microporous starch, hemostatic, biocompatibility

摘要： 为了制备玉米微孔淀粉止血剂，并对止血剂性能进行评价研究，采用酸酶序解法制备玉米微孔淀粉，测定其孔密度和吸水率，用动物创面出血模型检验其止血效果。研究结果显示，该方法所得微孔淀粉孔密度为3.4×104 /mm2，吸水率为156.98%，无病原微生物和内毒素；兔耳创面和兔肝脏创面完全止血时间分别在140 s和80 s之内，止血迅速、牢固，优于云南白药。研究结果表明，该微孔淀粉组织相容性良好，符合生物材料安全性的要求，可望开发为新型止血材料。

关键词: 玉米淀粉, 微孔淀粉, 止血剂, 生物相容性