journal1 ›› 2012, Vol. 2 ›› Issue (3): 177-183.DOI: 10.3969/j.issn.20952341.2012.03.04

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Progress of Research on Synthesis of Heparin Through Modification of Heparosan

WANG Chang, YAN Ziqin, Zhao Lei, Zhong Weihong   

  1. College of Biological and Environmental Enginerring, Zhejiang University of Technology, Hangzhou 310032, China
  • Received:2012-03-21 Online:2012-05-25 Published:2012-04-23

基于修饰Heparosan合成肝素的研究进展

王畅,严子琴,赵雷,钟卫鸿*   

  1. 浙江工业大学, 生物与环境工程学院, 杭州 310032
  • 通讯作者: 钟卫鸿，教授，博士生导师，从事应用和环境微生物及基因工程研究。Email：whzhong@zjut.edu.cn
  • 作者简介:王畅,硕士研究生,研究方向为微生物药物和基因工程。
  • 基金资助:

    国家自然科学基金项目(21076195);教育部博士点基金项目(2011331711004);浙江省科技厅国际合作项目(2011C24007)资助。

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Abstract: Heparin and heparin sulfate have been widely used as anticoagulant drugs in clinical application, and may play an important role in anticancer and antivirus. Traditional chemical synthesis of heparin is costly and tedious, although this approache has successfully manufactured heparin. Synthesis of heparin and its derivatives from microorganism became a hot topic. This article summarizes the structure and function of heparin, the recent progress on the chemical and enzymatic synthesis of heparin/heparan sulfate, and the application prospect of heparosan.

Key words: heparosan, sulfating modification, heparan sulfate, heparin

摘要： 肝素和硫酸乙酰肝素是一种被广泛应用于临床中的抗凝血药物多糖,其在抗癌、抗病毒等方面也具有一定的作用。化学合成肝素的成本高,且合成过程复杂,利用微生物来源的heparosan作为肝素前体的酶化学方法合成肝素,已成为一大研究热点。本文综述了肝素和硫酸乙酰肝素的结构和生物学功能及其酶学和化学方法合成的相关研究,并对其应用前景进行了展望。

关键词: heparosan, 硫酸化修饰, 硫酸乙酰肝素, 肝素

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