关键词: 腺相关病毒, AAV, 载体, 基因治疗, 血清型

Abstract: Vectors used to carry foreign genes play an important role in gene therapy,among which, the adeno-associated virus(AAV) has many advantages, such as nonpathogenicity, low immunogenicity, stable and long-term expression and multiple-tissue-type infection, ect. AAV is one of the hottest and most hopeful vectors in current days and has been extensively used in clinical research. With the research and development of AAV vector, the new vector systems will play a more important role in gene therapy. This review describes the recent development of AAV vector including the serum type, the new vector systems, the production processes and the scale up, the AAV-mediated clinical trials, the problems remained and the possible solutions. With the development of AAV vector, new vector system will play more important role in gene therapy.

Key words: adeno-associated virus(AAV), vector, gene therapy, serum type