关键词: 炎症, 炎性微环境, 眼部肿瘤, 恶性转化

Abstract: The mechanism of inflammation transforming into cancer has always been the focus of cancer research. As the environment in which inflammation-tumor transformation starts, inflammatory microenvironment is a large collection of various regulatory factors and cells, including tumor stem cells, tumor-related macrophages and cytokines (such as chemokines and growth factors) that play crucial roles in the process of tumor initiation, occurrence, evolution and even malignant transformation and metastasis in common ocular tumors. Based on this, the effects of tumor-related cells, cytokines and extracellular matrix in inflammatory microenvironment on the proliferation, metastasis, infiltration and invasion of tumor cells were mainly discussed, with emphasis on the molecular mechanism related to ocular inflammation-tumor transformation. The characteristics of common ocular tumors, such as retinoblastoma and adenoid cystic carcinoma, and the molecules that play  important regulatory roles in the process from inflammation to tumorigenesis were also reviewed. Finally, the future diagnosis and treatment methods were prospected for the ubiquitous signal pathways and molecular targets of these ocular tumors, so as to design ideas for the mentioned inflammatory components in the future diagnosis and treatment of ophthalmic tumors, and to maximize the prevention of inflammation-tumor transformation and malignant transformation.

Key words: inflammation, tumor microenvironment, ocular tumor, malignant transformation