关键词: 胶质母细胞瘤, 免疫治疗, 疫苗, T细胞, 临床试验

Abstract: Immunotherapy aims to increase the bodys immune response to tumors. The primary means used today include increasing the immune response in the body part or generating a corresponding immune response against the targeted antigen stimulating organism. Among them, the latter usually introduces cells that restart the immune response into the body to directly act on the target antigen by the immune system. Clinically, immunotherapy is mainly applied to the treatment of solid tumors such as melanoma and prostate tumor. The central nervous system was once thought to be an immune privilege zone, but in recent years a large number of studies have shown that the brains immune system is at a high level of activation and can interact with brain tumors. Therefore, research and use of this immune function is very important for the development of treatment of malignant brain tumors. This article summarized recent advances in immunotherapy for malignant glioblastoma, and provided a detailed introduction to the immunological mechanisms of central nervous system and glioblastoma, immunotherapy vaccines, and T cell therapy in cancer therapy.

Key words: glioblastoma, immunotherapy, vaccine, T cell, clinic trail