Abstract: Epstein-Barr virus（EBV）, as one of the viruses with high infection rate worldwide, is related to the occurrence of nasopharyngeal cancer, gastric cancer, breast cancer, cervical cancer and many other tumors. Toll-like receptors (TLRs) as the components of the innate immune system, play important roles in the process of the body  defending against the virus. When the body is stimulated by EBV, it can trigger the innate immune response by activating the TLRs signaling pathway, so as to control the further infection of EBV. But EBV can also regulate host immune through a series of pathways to maintain its own persistent infection in the host. Therefore, the study on the interaction mechanism between EBV and innate immune TLRs signaling pathway is of great significance to further elucidate the regulatory mechanism of latent and lytic infection of EBV and its pathogenicity. The progress on the interaction between EBV and TLRs signaling pathway was summarized in order to provide some references to develop new therapeutic targets of EBV and improve the clinical program of TLRs agonists.

Key words: EBV, TLRs signaling pathways, reactivation, innate immune, virus-host interaction

摘要： EB病毒（Epstein-Barr virus，EBV）作为全球范围内高感染率的病毒之一，与鼻咽癌、胃癌、乳腺癌及宫颈癌等众多肿瘤的发生有关。Toll样受体（Toll like receptors，TLRs）作为先天免疫系统的组成成分，在机体抵御病毒的过程中发挥着重要作用。当机体受到EBV刺激，可通过激活TLRs信号通路引发固有免疫应答，从而控制EBV的进一步感染，但EBV也可通过一系列途径调控宿主免疫，维持其自身在宿主内的持续性感染。因此，研究EBV与固有免疫TLRs信号通路之间的相互作用机制，对于进一步阐明EBV的潜伏感染、裂解感染的调控机理及其致病性具有重要意义。主要阐述了EBV与TLRs信号通路之间相互作用的研究进展，以期为开发新的EBV治疗靶点以及完善TLRs激动剂的临床方案提供一定的参考。

关键词: EB病毒, Toll样受体信号通路, 再次激活, 固有免疫, 病毒-宿主相互作用